Mineral Physics of the Earth's Core. Most information on the nature of Earth's core properties has come from teleseismic studies, which detect weak earthquake-wave signals that have traversed the Earth's deepest interior. These studies have revealed several unusual and enigmatic phenomena in the core, but interpretation of these observations must rely on mineral-physics data on the materials of the core (e.g. iron-based alloys). This project will create a unique world-class ultra-high pressure l ....Mineral Physics of the Earth's Core. Most information on the nature of Earth's core properties has come from teleseismic studies, which detect weak earthquake-wave signals that have traversed the Earth's deepest interior. These studies have revealed several unusual and enigmatic phenomena in the core, but interpretation of these observations must rely on mineral-physics data on the materials of the core (e.g. iron-based alloys). This project will create a unique world-class ultra-high pressure laboratory to obtain such data. By defining the composition and mineralogy of Earth's core, it will place Australia in the forefront of this exciting research field, and will also represent a major national resource for the study of novel materials at extreme conditions.Read moreRead less
UNDERSTANDING PHASE TRANSITIONS THROUGH PRECISE STRUCTURAL STUDIES. This project will examine the fundamental nature of the structural phase transitions that are critical for the utilisation of numerous advanced materials. Researchers at Sydney University and the Australian National University in collaboration with staff at ANSTO are world leaders in the structural analysis of such materials. Through comprehensive experimental and theoretical studies of a number of such materials this project w ....UNDERSTANDING PHASE TRANSITIONS THROUGH PRECISE STRUCTURAL STUDIES. This project will examine the fundamental nature of the structural phase transitions that are critical for the utilisation of numerous advanced materials. Researchers at Sydney University and the Australian National University in collaboration with staff at ANSTO are world leaders in the structural analysis of such materials. Through comprehensive experimental and theoretical studies of a number of such materials this project will enhance the ability of industry to develop new and improved materials.Read moreRead less
Platinum-group Metal Oxides with Modulated Crystal Structures: Flexible Frameworks Designed for Geometrically Frustrated Magnetism. Magnetic materials are of huge importance to modern society because of the key roles they play in devices such as hard disks, sensors, switches and permanent magnets. This project will focus on the chemical design and synthesis of novel, flexible and unconventional magnetic materials. Their study will lead to improved theories of magnetism and superconductivity, and ....Platinum-group Metal Oxides with Modulated Crystal Structures: Flexible Frameworks Designed for Geometrically Frustrated Magnetism. Magnetic materials are of huge importance to modern society because of the key roles they play in devices such as hard disks, sensors, switches and permanent magnets. This project will focus on the chemical design and synthesis of novel, flexible and unconventional magnetic materials. Their study will lead to improved theories of magnetism and superconductivity, and ultimately to technologies such as new data-storage media. The project will also help introduce Australian scientists to their new research reactor and synchrotron, which will play critical roles by allowing exceptionally thorough and systematic studies to be carried out.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies. This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that tr ....Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies. This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that translate external signals into the right cellular responses. The proposed experiments will provide a unique structural framework by which we can understand how these signals are transmitted. Such knowledge is an important foundation for advances in biomedical research and biotechnology applications.Read moreRead less
Molecular mechanisms of two-component signal transduction in bacteria. The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcom ....Molecular mechanisms of two-component signal transduction in bacteria. The focus of this research is on the protein complexes that transmit signals in bacteria to elicit the desired responses to environmental stimuli. Like many dynamic processes in cells, signaling requires proteins that are flexible and hence resistant to high-resolution structural analysis using crystallography. We will make use of new research infrastructure at the Australian synchrotron and OPAL research reactor to overcome the challenges of flexibility in these systems. The proteins we will study are not found in humans, and hence our research will provide important structural data on potential targets for the design of novel antibiotics to fight bacterial infection.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882855
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High-resolution imaging of live cells and tissue. Understanding the machinery of life and developing technologies that support life's processes requires biological and physical scientists and engineers to monitor molecular events in living systems. The aim is to take advantage of very recent developments in light microscopy to enable the non-invasive imaging of live cells and tissue at a previously unreachable level of detail. The instruments will form the nucleus of a new imaging facility. Sign ....High-resolution imaging of live cells and tissue. Understanding the machinery of life and developing technologies that support life's processes requires biological and physical scientists and engineers to monitor molecular events in living systems. The aim is to take advantage of very recent developments in light microscopy to enable the non-invasive imaging of live cells and tissue at a previously unreachable level of detail. The instruments will form the nucleus of a new imaging facility. Significant advances in research areas including vascular research, cancer, immunology, cell and molecular biology, functional genomics, biotechnology, nanotechnology and material engineering will be of major benefit both nationally and globally.Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less