Targeted Development Of AMPK Β2-isoform Allosteric Activators
Funder
National Health and Medical Research Council
Funding Amount
$898,147.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.
Cellular Regulation Of Receptor Signalling And Cytokine Responses
Funder
National Health and Medical Research Council
Funding Amount
$859,288.00
Summary
Cell surface receptors and signalling pathways elicit the release of cytokines, or chemical messengers, to control inflammation, which is the body’s response to infection or danger. We have discovered a new signalling pathway that can turn off inflammation and help prevent inflammatory disease. Our studies will now define the molecular details of this pathway and show how new and existing drugs targeting this pathway can be optimally used to treat inflammation and cancer.
A New Master Adaptor Protein For Toll-like Receptor Signalling
Funder
National Health and Medical Research Council
Funding Amount
$869,288.00
Summary
Certain proteins on the surface of cells are able to sense danger and infection. These receptors use adaptor proteins to enable cells to respond appropriately. We have discovered a new adaptor that controls receptor signalling in inflammation. This new master adaptor likely has widespread roles in infection and inflammation. We aim to understand how this adaptor works, and to identify ways of blocking its actions. These studies may help us to control inflammation underpinning many diseases.
Improving engagement in learning and transition to mainstream schooling for newly-arrived Sudanese youth in the middle years of schooling. The 'new wave' of Sudanese refugees (48.3% of 2003 intake) with disrupted educational and social/emotional backgrounds is currently challenging Australian schools' expertise and resources. Using frameworks that draw on cultural theory, identity and language, the study will explore the social capital needs (skills and capacities, and resource needs) of Sudanes ....Improving engagement in learning and transition to mainstream schooling for newly-arrived Sudanese youth in the middle years of schooling. The 'new wave' of Sudanese refugees (48.3% of 2003 intake) with disrupted educational and social/emotional backgrounds is currently challenging Australian schools' expertise and resources. Using frameworks that draw on cultural theory, identity and language, the study will explore the social capital needs (skills and capacities, and resource needs) of Sudanese middle-schooling students enabling successful, productive and engaged transition from their on-arrival program into mainstream secondary schooling. The resulting model and web-based materials will provide a framework for educating other groups likely to follow from Africa/elsewhere, and meet the National Priority Goal: strengthening Australia's social fabric.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic co ....The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic complexity, lexical range, accuracy and fluency) play in the attainment of advanced proficiency. Read moreRead less
Tropical Infectious Diseases - Pathogenisis And Vaccine Research
Funder
National Health and Medical Research Council
Funding Amount
$7,311,989.00
Summary
The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long hi ....The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long histories of collaboration as well as younger members with impressive credentials that are new to the collaboration. The fourth theme of the work proposed is concerned with inventive new ways of making such vaccines by novelchemical methods. It has already been the subject of published collaborative work onstreptococcal disease and is equally applicable to the other themes.Read moreRead less
Tense and topic in English as an Asian lingua franca. Using the Asian Corpus of English (ACE), this project will investigate linguistic features of 'Asian' English, how Asian multilinguals use English with each other and consider the implications of this for regional communication and English language teaching.
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.