Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to ....Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to revolutionise biology to investigate the wheat-fungus interaction. We will develop new effective approaches for environmentally benign stripe rust control based on new knowledge about how this fungus causes disease and avoids the wheat's immune surveillance system.Read moreRead less
Particle astrophysics with the Pierre Auger observatory. Australia's scientific reputation is enhanced through participation in international collaborations that aim to solve long-standing mysteries in science. The Pierre Auger Observatory covers a huge 3000 square km in western Argentina, where we are attempting to solve one of the biggest puzzles in modern astrophysics - the origin of the highest energy cosmic rays, particles 100 million times more energetic than we can produce on Earth. Ade ....Particle astrophysics with the Pierre Auger observatory. Australia's scientific reputation is enhanced through participation in international collaborations that aim to solve long-standing mysteries in science. The Pierre Auger Observatory covers a huge 3000 square km in western Argentina, where we are attempting to solve one of the biggest puzzles in modern astrophysics - the origin of the highest energy cosmic rays, particles 100 million times more energetic than we can produce on Earth. Adelaide scientists were founding members of the Auger project, and now have leading roles within the experiment. This is providing our students with access to world-class facilities and researchers in a field which has moved to the mainstream of astrophysics research.Read moreRead less
The geochemical role of iron in basaltic magmatism and planetary differentiation: an experimental study. The amount of Fe in primitive terrestrial basalts is surprisingly variable. The reasons for this are poorly understood, but could include melting of Fe-enriched refertilized mantle sources, increasing partitioning of FeO into the melt with depth of melting, or oxidation of some FeO to Fe2O3. An experimental investigation of the effects of Fe both as 2+ and 3+ on the partial melting of model ....The geochemical role of iron in basaltic magmatism and planetary differentiation: an experimental study. The amount of Fe in primitive terrestrial basalts is surprisingly variable. The reasons for this are poorly understood, but could include melting of Fe-enriched refertilized mantle sources, increasing partitioning of FeO into the melt with depth of melting, or oxidation of some FeO to Fe2O3. An experimental investigation of the effects of Fe both as 2+ and 3+ on the partial melting of model mantle material should help resolve this problem, while also providing the fundamental thermodynamic data needed to calibrate a general model for upper mantle phase relations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238884
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to ....Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to be discovered with this new instrument. This project will provide an Australian infrastructure contribution to support the multi-million dollar contribution of our Japanese partners, and thus provide Australian access to a key astrophysical field at very modest cost.Read moreRead less
Understanding the deep mantle: experimental petrology at very high pressures. The great processes that shape the Earth at its surface, including plate tectonics and continental drift, can only be understood by appreciating how the interior of the Earth works. However, studying the deep Earth is difficult because of the enormous pressures and temperatures involved. This research proposes to simulate conditions in the Earth's lower mantle (that is, below 670 km in depth) by making use of an Austra ....Understanding the deep mantle: experimental petrology at very high pressures. The great processes that shape the Earth at its surface, including plate tectonics and continental drift, can only be understood by appreciating how the interior of the Earth works. However, studying the deep Earth is difficult because of the enormous pressures and temperatures involved. This research proposes to simulate conditions in the Earth's lower mantle (that is, below 670 km in depth) by making use of an Australian invented diamond-based ceramic, to double the pressure at which experiments can be performed. The information gained from this fundamental research will help predict how giant ore bodies form. The development of the high-pressure apparatus will also aid material scientists in their quest for novel materials.Read moreRead less
Water storage in the earth's mantle - understanding the process of OH incorporation in olivine. The amount of water in the Earth's mantle is thought to be sufficient to replace the surface oceans more than ten times. Whether this water exists in a fluid, melt, or mineral is important for understanding a range of mantle properties. The entire upper mantle water budget may be accommodated at defect sites in the mineral olivine. However, defects found in natural olivine do not correspond to thos ....Water storage in the earth's mantle - understanding the process of OH incorporation in olivine. The amount of water in the Earth's mantle is thought to be sufficient to replace the surface oceans more than ten times. Whether this water exists in a fluid, melt, or mineral is important for understanding a range of mantle properties. The entire upper mantle water budget may be accommodated at defect sites in the mineral olivine. However, defects found in natural olivine do not correspond to those produced
experimentally. Therefore, previous conclusions on water storage in the mantle are questionable. To address this problem the mechanism of water incorporation in olivine will be investigated using experimental petrology and spectroscopy.Read moreRead less
Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broa ....Experimental constraints on Platinum-Group Element geochemistry: developing lithogeochemical exploration tools for nickel-sulfides in mafic and ultramafic systems. Nickel contributes approximately $2 billion per year to Australia's export income. Currently 80% of that is coming from sulfide deposits, which are expected to be exhausted within thirty years barring significant new discoveries. Discovery rates have been declining for two decades, as the 'easy' targets have been found, despite a broad increase in nickel exploration expenditure to current levels of around $50 million per year. There is a pressing need for new data sets and techniques to allow industry to target new discoveries based on limited drill sampling of potential host rocks. This project forms part of a broader program to harness the igneous geochemistry of the platinum group elements as a powerful pathfinder in nickel exploration.Read moreRead less