Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they sh ....Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they should provide significant advantages over conventional detection strategies. These advantages include increased sample throughput and conservation of biological samples, which makes possible the acceleration of patient diagnosis and drug discovery. Read moreRead less
Chemical synthesis of cancer-associated glycoproteins. Glycosylation of proteins is an extremely common event which plays an important role in a variety of biological processes. Aberrant glycosylation and over-production of glycoproteins is associated with numerous cancer types (including breast, prostate, ovarian and small lung) and are recognised as promising agents for disease diagnosis and vaccine development. A range of cancer-associated glycoproteins will be synthesised in this research p ....Chemical synthesis of cancer-associated glycoproteins. Glycosylation of proteins is an extremely common event which plays an important role in a variety of biological processes. Aberrant glycosylation and over-production of glycoproteins is associated with numerous cancer types (including breast, prostate, ovarian and small lung) and are recognised as promising agents for disease diagnosis and vaccine development. A range of cancer-associated glycoproteins will be synthesised in this research program using a number of novel chemical technologies. These glycoproteins will be used to develop cancer vaccines and diagnostics. Cancer is a severe burden on the Australian community and on the economy, therefore this research will be of significant benefit to Australia.Read moreRead less
Construction and Use of Yoctowells as Vessels for Catalysis, Sensing and Artificial Photosynthesis. Yoctowell recognition systems are likely to form the basis of a new generation of biosensors, high throughput screening systems for identification of nucleotides and as energy transduction systems. As a result, this research will be relevant to technological advances in the areas of biotechnology and nanotechnology. Researching functional yoctowells containing photoactive and redox-active componen ....Construction and Use of Yoctowells as Vessels for Catalysis, Sensing and Artificial Photosynthesis. Yoctowell recognition systems are likely to form the basis of a new generation of biosensors, high throughput screening systems for identification of nucleotides and as energy transduction systems. As a result, this research will be relevant to technological advances in the areas of biotechnology and nanotechnology. Researching functional yoctowells containing photoactive and redox-active components will contribute to the major effort in basic research on smart optoelectric that are needed today to meet tomorrow's energy demands in a sustainable way. Read moreRead less
Design of Novel Polymer Micro-Porous Coatings. This project utilises unique polymer structures that self-organise into highly-ordered polymer films. These polymer films have arrays of pores with pore diameters on the micron scale. These films are suitable for high-technology membranes applications, in for instance, biosensors.
Novel Hydrogels for Bioseparations in Clinical Applications. The project aims to design and synthesise new highly swollen hydrophilic membranes for use in biological separation processes and purifications such as the removal of viruses from blood. Typical membrane problems like membrane fouling or low flux should be minimized by a narrow pore size distribution. The regular nano-patterning should be obtained by molecular impriniting technique. Novel thermoresponsive polymers, which will be polyme ....Novel Hydrogels for Bioseparations in Clinical Applications. The project aims to design and synthesise new highly swollen hydrophilic membranes for use in biological separation processes and purifications such as the removal of viruses from blood. Typical membrane problems like membrane fouling or low flux should be minimized by a narrow pore size distribution. The regular nano-patterning should be obtained by molecular impriniting technique. Novel thermoresponsive polymers, which will be polymerized via controlled free radical polymerization techniques, will be used as biocompatible membrane material.Read moreRead less
The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this a ....The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this assay could provide a useful diagnostic tool in a clinical environment that would allow for the rapid assessment of these diseases, their progression and indeed response to therapy.Read moreRead less
Design of Polymeric Devices for Biotechnological Applications. The research project focuses on the development of functional polymer particles for diagnostic applications. Advanced polymer chemistry will be used to synthesize devices for reliable and fast diagnostic systems. The outcome of this work will help promoting and maintaining good health in Australia by developing novel technologies and advanced materials based on polymer science.
Polymer Stabilized and Bio-functionalised Metal Nanoparticles As Potential Vectors For Drug Therapies. The project aims to make novel nanoparticles (extremely small, nano means one billionth of a metre) that carry medicines to very specific sites of the body and then release them. This would result in much improved outcomes for conventional chemotherapy but may also allow new gene therapies where diseases can be silenced at their source.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883068
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Dako ACIS III Cellular Image Acquisition and Analysis System. The scientific advances that will be possible with the acquisition of this novel, cutting-edge instrument will enhance the research outputs of all investigators using it. The ability to visualize and analyze cells and tissues from many different animal species, to elucidate both normal and abnormal functions, will be enhanced by the use of this technology. This will lead to production of quantitative statistical data that in turn will ....Dako ACIS III Cellular Image Acquisition and Analysis System. The scientific advances that will be possible with the acquisition of this novel, cutting-edge instrument will enhance the research outputs of all investigators using it. The ability to visualize and analyze cells and tissues from many different animal species, to elucidate both normal and abnormal functions, will be enhanced by the use of this technology. This will lead to production of quantitative statistical data that in turn will inform new approaches to improve and maintain the health of humans and other animals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989105
Funder
Australian Research Council
Funding Amount
$495,000.00
Summary
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry. Biomolecular research and research training, in which proteomics is core, has become a critical component of post-industrial development in the Hunter region. Development of a cutting edge proteomics facility will benefit a research community comprising over 50 researchers and 150 undergraduate students significantly enhancing their research productivity and translation of outcomes in areas of national i ....An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry. Biomolecular research and research training, in which proteomics is core, has become a critical component of post-industrial development in the Hunter region. Development of a cutting edge proteomics facility will benefit a research community comprising over 50 researchers and 150 undergraduate students significantly enhancing their research productivity and translation of outcomes in areas of national importance. These include understanding the impact of the environment on plant and animal development, pest animal control, development of new biotechnology tools, new drugs and new methods for the detection of narcotics and explosives.Read moreRead less