PRevention & Early Intervention In Mental Illness And Substance UsE (PREMISE CRE)
Funder
National Health and Medical Research Council
Funding Amount
$2,495,969.00
Summary
Substance use and mental disorders are among the leading causes of burden of disease in young people globally. Effective prevention and early intervention can reduce disease burden by halting, interrupting or delaying the onset and development of disorder. The PREMISE CRE will build the science to move the field from crisis, acute care and containment to prevention and early intervention, achieving a critical aim of the Australian Government’s program of reform in mental health and addiction.
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Access to justice in interpreted proceedings: the role of Judicial Officers. This project aims to examine the ways judicial officers can improve courtroom communication and prevent miscommunication and error, particularly in criminal cases where speakers of the 'new and emerging' and Aboriginal languages are involved, and where interpreters receive limited or no specialised training. Using an innovative interdisciplinary approach, the project aims to generate new knowledge in examining the varia ....Access to justice in interpreted proceedings: the role of Judicial Officers. This project aims to examine the ways judicial officers can improve courtroom communication and prevent miscommunication and error, particularly in criminal cases where speakers of the 'new and emerging' and Aboriginal languages are involved, and where interpreters receive limited or no specialised training. Using an innovative interdisciplinary approach, the project aims to generate new knowledge in examining the variations in judicial officers communications practice when working with interpreters, and their impact on the effective transmission of information in the courtroom. Expected outcomes of this project will include improved outcomes of interpreted communication and a better access to justice for non-English speaking participants.Read moreRead less
Interpreters in court: witness credibility with interpreted testimony. The study will improve access to justice for non-English speaking witnesses, testifying in court through an interpreter. It achieves this by taking advantage of new wireless technologies to transform the social and technological environment of the courtroom.
Mode, accuracy and credibility in court interpreting. This project aims to examine factors affecting the accuracy of interpreting and the effect of interpreters on witness credibility. Judicial cases rely on oral evidence. Witness credibility is assessed based on the content of the testimony and the speaker’s demeanour. When witnesses do not speak English, their credibility is evaluated through an interpreter. Inaccurate interpretations can result in miscarriages of justice, making accuracy of i ....Mode, accuracy and credibility in court interpreting. This project aims to examine factors affecting the accuracy of interpreting and the effect of interpreters on witness credibility. Judicial cases rely on oral evidence. Witness credibility is assessed based on the content of the testimony and the speaker’s demeanour. When witnesses do not speak English, their credibility is evaluated through an interpreter. Inaccurate interpretations can result in miscarriages of justice, making accuracy of interpretation essential. This project aims to provide empirical evidence to support best practice and a basis for policy recommendations to courts to enhance the fairness of the justice system for all members of the community, regardless of language and background.Read moreRead less
Participation in the administration of justice: deaf citizens as jurors. This project will pioneer international research on legal signed language interpreting and jury service; the results are likely to innovate law reform. The expected outcome will be to overturn previously held common law that deaf people cannot serve as jurors due to having an interpreter as the 13th person in the jury room as well as confidentiality issues.
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
A Cross-National and Cross-Cultural Study of Global Translation Industry. This project aims to tackle the pressing issue of the social invisibility of the translation profession, a persistent social problem that threatens to hinder the development of a critical knowledge-based industry in Australia within a rapidly changing international social, economic and cultural context. The project is expected to offer insights into the emerging international translation system and inform policy makers an ....A Cross-National and Cross-Cultural Study of Global Translation Industry. This project aims to tackle the pressing issue of the social invisibility of the translation profession, a persistent social problem that threatens to hinder the development of a critical knowledge-based industry in Australia within a rapidly changing international social, economic and cultural context. The project is expected to offer insights into the emerging international translation system and inform policy makers and the general public about the challenges and opportunities of developing this profitable and resilient service industry.Read moreRead less