Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time informat ....Eat, cook, grow: Ubiquitous technology for sustainable food culture in the city. Raising people's awareness of healthy and ecological food options with nutritional data and educational information does not foster a sustained practice towards a more environmentally friendly food culture. This study seeks to develop a better understanding how to go beyond just informing and into supporting and sustaining action and change. Drawing on interaction design, ubiquitous computing and real- time information, the study will deliver research findings that inform viable new design approaches and information interfaces which will strengthen Australia's position to resolve the problems of obesity, malnutrition and ecological issues of mass food processing, and contribute to the sustainability of life in Australian cities.Read moreRead less
Sociophysical Interactions: understanding the role of social and tangible technologies in maintaining good habits into old age. How can technology help us 'age well'? The project will study, design and evaluate novel information systems that integrate and support social engagement and physical activity in order to build foundational knowledge about these technologies and maintain the opportunities for social engagement and physical activity in our ageing population.
Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a vari ....Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a variety of surveillance techniques will evaluate content design and user response. Children's viewing habits will be evaluated within a social context (the home) and a mobile lab setting using qualitative and quantitative assessment. The results will identify effective ways to produce meaningful interactivity and will encourage future industry based research.Read moreRead less
Special Research Initiatives - Grant ID: SR0354753
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communic ....MESH: amalgamating innovative teams of cross-disciplinary collaborators for creativity in Media-arts, E-culture, Science and Humanities. MESH is a cross-disciplinary network that amalgamates a national array of sub-networks of research in digital arts, ICT and cross-cultural and policy negotiation. It boosts Australia's existing cross-disiciplinary strengths in Media-arts, E-culture, Science and Humanities by encouraging existing digital sub-networks to grow together via well-brokered communications and demonstrations online and on-location. Progressively, MESH participants will discover existing harmonies whilst also inventing new languages and protocols leading to breakthroughs in cross-disciplinary collaboration and innovation. MESH encourages a 'paradigm shift' in digital research, realising the extraordinary potential that is ready but latent across Australia's arts and sciences.Read moreRead less
Bio-Acoustic Observatory: Engaging Birdwatchers to Monitor Biodiversity by Collaboratively Collecting and Analysing Big Audio Data. This project will research how to crowd-source the collection and analysis of environmental animal sounds (for example, birds, frogs). This will enable a bio-acoustic observatory which provides a scalable, objective and permanent record of the environment, something hitherto impossible. The project will investigate how to engage the community of birdwatchers to exte ....Bio-Acoustic Observatory: Engaging Birdwatchers to Monitor Biodiversity by Collaboratively Collecting and Analysing Big Audio Data. This project will research how to crowd-source the collection and analysis of environmental animal sounds (for example, birds, frogs). This will enable a bio-acoustic observatory which provides a scalable, objective and permanent record of the environment, something hitherto impossible. The project will investigate how to engage the community of birdwatchers to extend their pastime online with new kinds of interactive tools to enable collaborative analysis of big audio data, and new kinds of birding experiences. Outcomes will be: new approaches to physical/virtual engagement in human-computer interaction; new approaches to analysing big data; a new validated ecological monitoring technique and concepts for sustainable knowledge generation communities.Read moreRead less
Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlyin ....Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlying biological and biomedical processes, bringing sustainable discovery of new relationships and variations within the data. The project aims to support new approaches to medical diagnosis and treatment, and offer crucial lessons to address the broader challenge of understanding large, complex data sets.Read moreRead less
Special Research Initiatives - Grant ID: SR0567196
Funder
Australian Research Council
Funding Amount
$55,000.00
Summary
Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in c ....Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in conjunction with interactive visualisation with haptic feedback. Grid computing experience and haptic device expertise will be achieved via Swedish collaborators. The successful outcome of this project will be software for the production of 3D colour-coded breast images in which suspicious regions are highlighted and can be physically interrogated using the haptic device.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.