How Does NF-kB2 Regulate Thymic Selection To Prevent Organ-specific Autoimmune Disease?
Funder
National Health and Medical Research Council
Funding Amount
$787,600.00
Summary
Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limit ....Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limitations and the convergence properties of the proposed
algorithms. The outcomes will be widely applicable in modelling of
large scale and complex data as is encountered in areas of
bioinformatics, physics and experimental studies of complex systems.
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It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Software-defined provisioning of Internet of Things applications in fog computing systems. This project aims to investigate and provide solutions for the realisation of a seemingly integrated Fog Computing (FC) paradigm with cloud environments, networking devices and Internet of Things devices. Fog Computing (FC) is an emerging paradigm with great promises for advancing Information and Communications Technologies. Using interdisciplinary approaches, the project expects to generate new knowledge ....Software-defined provisioning of Internet of Things applications in fog computing systems. This project aims to investigate and provide solutions for the realisation of a seemingly integrated Fog Computing (FC) paradigm with cloud environments, networking devices and Internet of Things devices. Fog Computing (FC) is an emerging paradigm with great promises for advancing Information and Communications Technologies. Using interdisciplinary approaches, the project expects to generate new knowledge for optimising both hardware and software resources of a FC system. Outcomes of this project include practical solutions through building novel mathematical frameworks and optimisation objectives. The project is expected to provide efficient monitoring and control of intelligent spaces, management of urban and rural environments and will have applications in the areas of energy, security, transport and public health.Read moreRead less
Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be ....Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be assessed. The effect of the statistical dependency of attribute values will be studied. New methods using clustering for blocking large datasets, and predictive models including interaction terms will be implemented, analysed and evaluated on high-performance computers and office-based PC clusters.
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Singular phenomena for nonlinear partial differential equations arising in applications. The development of nonlinear Partial Differential Equations (PDEs) in Australia is recognized worldwide through the outstanding contributions of mathematicians from the ANU, University of Sydney and other top Australian Universities. This project undertakes research in the PDEs field and follows directions of very current interest at an international level. Beyond the ANU, the project will enhance expertise ....Singular phenomena for nonlinear partial differential equations arising in applications. The development of nonlinear Partial Differential Equations (PDEs) in Australia is recognized worldwide through the outstanding contributions of mathematicians from the ANU, University of Sydney and other top Australian Universities. This project undertakes research in the PDEs field and follows directions of very current interest at an international level. Beyond the ANU, the project will enhance expertise in Australia in very active areas of mathematics research related to applications in physics, biology and other applied disciplines. Moreover, it will foster collaboration with mathematicians of international standing from Australia and abroad. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100232
Funder
Australian Research Council
Funding Amount
$431,704.00
Summary
Demographic and life course drivers of social cohesion. The project aims to understand the individual and community-level drivers and pressures on social cohesion in Australia. It is expected to generate new knowledge on how and why individuals become more or less engaged in their communities and society over time by combining information from multiple existing data sources. Expected outcomes of the project include the creation of analytical tools for measuring the dynamics of social cohesion, h ....Demographic and life course drivers of social cohesion. The project aims to understand the individual and community-level drivers and pressures on social cohesion in Australia. It is expected to generate new knowledge on how and why individuals become more or less engaged in their communities and society over time by combining information from multiple existing data sources. Expected outcomes of the project include the creation of analytical tools for measuring the dynamics of social cohesion, helping to bridge the gap between current theories and data. This should provide significant benefits in identifying threats and opportunities, and informing community and government initiatives, to strengthen and maintain social cohesion and the collective well-being of communities and Australia.Read moreRead less
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Understanding The Pathogenesis And Heterogeneity Of Autoimmunity As Failure Of Multiple Steps
Funder
National Health and Medical Research Council
Funding Amount
$504,023.00
Summary
Autoimmune diseases like diabetes, thyroid disease or rheumatoid arthritis affect around 1 in 15 people in Australia. It is clear that defects in a number of different genetic mechanisms can contribute to the development of autoimmunity. But it is currently not clear how these different mechanisms need to interact to prevent the onset of disease. This grant seeks to understand these interactions and how defects in two or more tolerance mechanisms can lead to autoimmunity.