The tau interactome. This project aims to decipher tau-dependent mechanisms at the molecular level to understand its pivotal role in neuronal integrity and function. Tau is a predominantly axonal protein with microtubule stabilising properties and has been implicated in several neurodegenerative disorders, including Alzheimer’s disease. Knowledge of its other physiological roles in the brain is limited, although it seems to be involved in signalling processes. The expected outcome of this study ....The tau interactome. This project aims to decipher tau-dependent mechanisms at the molecular level to understand its pivotal role in neuronal integrity and function. Tau is a predominantly axonal protein with microtubule stabilising properties and has been implicated in several neurodegenerative disorders, including Alzheimer’s disease. Knowledge of its other physiological roles in the brain is limited, although it seems to be involved in signalling processes. The expected outcome of this study is a deeper understanding of brain function during development and aging, which may ultimately contribute to new preventive treatments and medical care strategies.Read moreRead less
The mode of action of the haem protein neuroglobin in protecting nerve cells. Outcomes from this project will assist in developing new treatments for stroke and chronic degenerative brain disorders by characterising how the haem protein neuroglobin protects neurons of the central and peripheral nervous system from oxidative damage. This project will also develop pharmacological strategies to boost the concentration of neuroglobin in neurons.