Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies i ....Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies identifying the major influences thereof. Expected outcomes include advances in knowledge of how conflictive uncertainty attitudes relate to risk orientations, personality, and situational factors. Anticipated benefits include improved strategies for decision makers and communicators faced with conflictive uncertainty.Read moreRead less
Emotions and Employee Turnover: New Methods for Complex Dynamic Systems. This project aims to vastly improve the data-analytic capabilities of social and health researchers, while increasing knowledge about emotion dynamics and their link to employee turnover. By drawing on and advancing methods from ecology and applied physics, this project plans to investigate the role that individual emotions play in employee turnover with new quantitative methods for characterising and testing causality in c ....Emotions and Employee Turnover: New Methods for Complex Dynamic Systems. This project aims to vastly improve the data-analytic capabilities of social and health researchers, while increasing knowledge about emotion dynamics and their link to employee turnover. By drawing on and advancing methods from ecology and applied physics, this project plans to investigate the role that individual emotions play in employee turnover with new quantitative methods for characterising and testing causality in complex dynamic systems. The expected outcomes include an improved capacity for researchers, managers, and policy makers to understand complex organisational, economic, and health systems. This will provide immediate societal benefits by informing the development and deployment of targeted interventions in such systems.Read moreRead less
Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of un ....Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of uncertainty are jointly affected by conflict and ambiguity in information, develop and test formal models of judgement and decision making under conflict and ambiguity, and examine the joint effects of ambiguity and conflict aversion on decision making.Read moreRead less
Zero-sum thinking: psychological predictors and causes. This project investigates the causes and psychological triggers of zero-sum thinking, the tendency to think that others' gains leave less for oneself. The results will enable negotiators and managers to defuse dysfunctional zero-sum thinking, thereby increasing the chances for cooperation and 'win-win' outcomes.
Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membran ....Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membrane and how these interactions affect the function of a complex membrane protein.Read moreRead less
Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutritio ....Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutrition. At a time where protein-rich diets are recommended to fight obesity and diabetes, it is important to understand the basis of protein absorption and metabolism. This project investigates the mechanism and mediators of amino acid absorption in kidney and intestine. Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulatio ....Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulation of non-coding transcripts and genomic instability. This work aims to understand eukaryotic genome organisation and may have long-term therapeutic implications for cancer and ageing-related diseases.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
The basis of conscious thought. The science and philosophy of consciousness has made much progress in recent years, and the study of conscious thought is the next frontier. The project will place Australian research on the leading edge of this area. An international network of researchers will analyse both the neurobiological basis and the subjective experience of conscious thought, yielding a unified account of conscious thinking from the first-person and third-person perspectives. The resultin ....The basis of conscious thought. The science and philosophy of consciousness has made much progress in recent years, and the study of conscious thought is the next frontier. The project will place Australian research on the leading edge of this area. An international network of researchers will analyse both the neurobiological basis and the subjective experience of conscious thought, yielding a unified account of conscious thinking from the first-person and third-person perspectives. The resulting account will illuminate the nature of human thinking and reasoning, and will be applied to the detection of consciousness in post-coma patients.Read moreRead less