Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and t ....Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and the physiological events measured by the scanning technologies. This has created a problem for how we should interpret the results that are found. The present project aims to close this gap by applying new research methodologies and theoretical insights based on our previous research.Read moreRead less
Are two processes one too many? An investigation of the viability of the dual-process model of recognition memory. Memory is the glue that holds together our lives and personal identities. While psychologists are developing better and more sophisticated accounts of how it works, many deep questions remain. The present research examines some of these questions in relation to how memory can be decomposed into its component processes and how we are to understand these processes. An appropriate unde ....Are two processes one too many? An investigation of the viability of the dual-process model of recognition memory. Memory is the glue that holds together our lives and personal identities. While psychologists are developing better and more sophisticated accounts of how it works, many deep questions remain. The present research examines some of these questions in relation to how memory can be decomposed into its component processes and how we are to understand these processes. An appropriate understanding of these questions is vital to the development of interventions (both psychological and pharmacological) designed to halt or even reverse memory decline associated with normal aging and age-associated brain disease (such as Alzheimer disease).Read moreRead less
Towards an integrated model of reasoning and reasoning development. This project aims to identify the core cognitive processes that underlie different forms of reasoning and how they develop. The project intends to use a signal detection framework to derive detailed computational models of reasoning which can then be tested through Bayesian computational modelling as well as the first systematic investigation of developmental change in reasoning processes. Expected outcomes include a more princi ....Towards an integrated model of reasoning and reasoning development. This project aims to identify the core cognitive processes that underlie different forms of reasoning and how they develop. The project intends to use a signal detection framework to derive detailed computational models of reasoning which can then be tested through Bayesian computational modelling as well as the first systematic investigation of developmental change in reasoning processes. Expected outcomes include a more principled and comprehensive computational model of reasoning in both adults and children. The project should provide significant benefits by helping to resolve long-standing debates about how humans reason complex arguments relevant to everyday lives and guide development of more effective methods for teaching reasoning.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561030
Funder
Australian Research Council
Funding Amount
$441,100.00
Summary
Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiative ....Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiatives in developmental and cellular biology. This large-scale, high-resolution expression profiling infrastructure is required to maintain international competitiveness and will dramatically improve our gene discovery, functional assessment and understanding of vertebrate development.Read moreRead less
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.
Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less
Investigation of recognition memory in behavioural, electrophysiological, and functional neuro-imaging domains using state-trace analysis. This project utilises a novel methodology to investigate human recognition memory across three separate domains - behavioural, electrophysiological and functional neuro-imaging. The aim is to determine how these three aspects of memory are related and if they can be united by a single theory.
State-trace analysis: theory and application. A fundamental question for the science of psychology is: how can we identify the functional components of the human mind from observed behaviour and bodily states? This project explores this question through a new methodology called state-trace analysis and apply it to a basic cognitive ability - the capacity to learn to classify different objects.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100057
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and ....A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and large sample size (up to 100 mm diameter). The project will enable progress in advanced composites, additive bio-manufacturing, physiology of biological tissues and palaeontology which will benefit Australian science. Additionally, through commercialisation and the formation of new companies, the project could potentially result in economic and health benefits to the wider Australian population and economy.Read moreRead less
Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.