Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Discovery Early Career Researcher Award - Grant ID: DE180100015
Funder
Australian Research Council
Funding Amount
$400,996.00
Summary
Understanding attitudes toward ambiguity: A multidimensional framework. This project aims to develop a comprehensive psychological framework and effective measures for assessing attitudes to ambiguity. Using empirical work and quantitative modelling, it will address the multidimensional nature of ambiguity, and likely individual and cultural differences. Attitudes to ambiguity strongly influence people's judgments and the expected outcomes from this project will enhance theoretical understandin ....Understanding attitudes toward ambiguity: A multidimensional framework. This project aims to develop a comprehensive psychological framework and effective measures for assessing attitudes to ambiguity. Using empirical work and quantitative modelling, it will address the multidimensional nature of ambiguity, and likely individual and cultural differences. Attitudes to ambiguity strongly influence people's judgments and the expected outcomes from this project will enhance theoretical understandings and measurement tools for psychological research in decision making. This project aims to provide significant benefits by developing novel strategies for improving decision making in contexts of ambiguity.Read moreRead less
Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of un ....Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of uncertainty are jointly affected by conflict and ambiguity in information, develop and test formal models of judgement and decision making under conflict and ambiguity, and examine the joint effects of ambiguity and conflict aversion on decision making.Read moreRead less
Zero-sum thinking: psychological predictors and causes. This project investigates the causes and psychological triggers of zero-sum thinking, the tendency to think that others' gains leave less for oneself. The results will enable negotiators and managers to defuse dysfunctional zero-sum thinking, thereby increasing the chances for cooperation and 'win-win' outcomes.
Motor Functioning In Autism And Asperger's Disorder: Furthering Current Neurobehavioural And Clinical Definitions
Funder
National Health and Medical Research Council
Funding Amount
$354,932.00
Summary
While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isol ....While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isolated and rejected from the peer group. Also, hand writing problems have a significant impact on children's academic performance. Our previous research has suggested that there may be particular patterns of motor problems that characterise individuals with autism and Asperger's disorder. Our proposed research aims to use the kinds of 3D motion analysis technology used in the movie industry to capture exactly how people affected by these conditions move and respond to the environment. This study will enable us to highlight particular parts of the brain-motor circuitry that are affected by these disorders and will also enable us to more clearly distinguish how autism is different from Asperger's disorder. Ultimately, it is hoped that our motor investigations will lead to improved assessment and interventions for these disorders.Read moreRead less
Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The p ....Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The project will also identify risk factors for problem gambling, and protective factors and policy opportunities for the reduction of problem gambling. It will also contribute to methodological knowledge by assessing the validity of multiple measures of problem gambling.Read moreRead less
Prevalence report by the Australian Advisory Board on Autism Spectrum Disorders (ASD) estimated that 1 child in every 160 children in the 6-12 year-old age group is affected by ASD. There is no cure for ASD and the causes are not understood. We propose that sex hormones may play a role in the development of these disorders. We will test this hypothesis using knockout and transgenic mouse models which have social interaction deficits and brain structure reminiscent of these disorders.
Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membran ....Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membrane and how these interactions affect the function of a complex membrane protein.Read moreRead less
Bioreactors for manufacture of human platelets. Blood cell transfusion is a critical part of medicine that is supported by volunteer donors. Unfortunately, the demand for blood cells for transfusion far outstrips supply and therefore new strategies are required for manufacture of blood cells. This project will lead to the development of technology for manufacture of human platelets from stem cells. The systems devised will be applicable to a broad range of other blood cell types.
Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutritio ....Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutrition. At a time where protein-rich diets are recommended to fight obesity and diabetes, it is important to understand the basis of protein absorption and metabolism. This project investigates the mechanism and mediators of amino acid absorption in kidney and intestine. Read moreRead less