I will determine the efficacy and safety of crystalloid resuscitation fluids in conventional models of care. This is a fundamental and unresolved question in Intensive Care Medicine and will have an impact on clinical practice worldwide. I will also consolidate and enhance a series of projects to provide the next generation of clinician-researchers with high-quality research opportunities. These include projects in sepsis, traumatic brain injury, and endocrine function in critical illness.
Precision Medicine For Epilepsy And Beyond: From Discovery To Implementation And Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$487,891.00
Summary
The theme of this Fellowship is to improve treatment outcomes using a genomic-based Precision Medicine approach. This goal will be achieved by 3 closely linked projects that harness the power of gene sequencing and advances in biosensor technology, coupled with careful clinical and health economic evaluation. While the emphasis is on epilepsy, the research will extend to other major disease areas of global health significance. The potential socioeconomic impact of these innovations is enormous.
Immunisation is second only to clean water and sanitation as a life-saving activity. Vaccine safety is considered to be very important by the general public, the media and the health professions. With so many diseases controlled and now rare, the safety of vaccines assumes greater importance. Research is needed on new and safer vaccines, using e.g. a needle-free approach, against old foes, like influenza, and new enemies (like MERS) with vaccine safety more important than ever.
Generating And Translating Evidence Into Practice In Womens Health And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$501,659.00
Summary
Obesity is increasing with major reproductive and metabolic health impacts for women and the next generation. This fellowships focuses on prevention of obesity and optimal diagnosis and management of obesity related reproductive and metabolic conditions in women including before and during pregnancy. Translation is vital to deliver health benefits from research. Here Prof Teede will generate new evidence and translate this into practice in women’s health and beyond to deliver tangible impact.
Determinants Of The Outcomes From Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$532,630.00
Summary
Professor Lloyd will continue studies of the factors which lead to varied clinical outcomes from common infectious diseases. The outcomes include chronic or persistent illness, rather than prompt recovery. The factors being studied include aspects of the microbes causing the infection; and aspects of the individual suffering from infection, including genetic make-up, immune defences, and treatment responses. The infections studied include common "flu-like" illnesses, as well as hepatitis C.
This Practitioner Fellowship will support studies that will contribute directly to the efforts to eliminate HCV infection from Australia. The research program aims to reduce transmission of HCV infection by evaluating the best models of care for i) engaging and treating high risk individuals with HCV infection, including people who inject drugs and prisoners, ii) preventing reinfection with HCV, and iii) re-treatment of individuals who fail treatment due to drug resistance.
An Integrated Research Program In Clincial Toxicology Toxicovigilance And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Drug-related deaths in Australia account for 6.6% of all deaths (ABS 2009). In much of the rural Asia-Pacific, pesticide poisoning and snakebite are major problems. This research supports an integrated national and international clinical toxicology research program covering medicine and chemical poisoning, serious adverse drug reactions, snake and spider bite. Its focus is on the applied research needed to detect new problems and rapidly translate early findings into better treatment, regulation ....Drug-related deaths in Australia account for 6.6% of all deaths (ABS 2009). In much of the rural Asia-Pacific, pesticide poisoning and snakebite are major problems. This research supports an integrated national and international clinical toxicology research program covering medicine and chemical poisoning, serious adverse drug reactions, snake and spider bite. Its focus is on the applied research needed to detect new problems and rapidly translate early findings into better treatment, regulations & policy.Read moreRead less