Improving Cardiovascular Outcomes Through Better Trials
Funder
National Health and Medical Research Council
Funding Amount
$1,714,215.00
Summary
Randomised trials are the cornerstone of high quality medical practice. There is an urgent need to do more trials but there are major challenges - timely recruitment of participants, inclusion of representative patients and control of costs are issues we face every day. I will commence a series of new trials evaluating interventions for cardiovascular disease. In parallel I will develop and test innovative solutions to the practicalities of doing large-scale studies.
Understanding And Improving Outcomes Due To Sepsis In At-risk And Underserved Populations
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Sepsis is life-threatening organ failure that occurs in response to infection. Each year, 19 million adults suffer from sepsis and 6 million die. My research will measure sepsis risk factors and frequency in ageing Australians and new mothers (Australia and Vietnam). I will measure the long term impact of sepsis to better understand how sepsis impacts survivors and their families. I will develop and implement relevant, culturally appropriate and evidence-based strategies to reduce sepsis.
Advancing The Radical Cure Of Plasmodium Vivax Malaria Through Optimal Antimalarial Regimens
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
Forty percent of the global population are at risk of vivax malaria and its associated morbidity. Complete cure of vivax malaria can result in severe anaemia caused by adverse effects of primaquine in vulnerable individuals. My research will provide important evidence for national malaria programs and clinicians, identifying the optimal dosing regimen across different ages and locations, that balances the risks and benefits of primaquine treatment.
Driving Advances In Sugar-sweetened Beverage Policy And Resolving The Unknown Substitution Effects Into Artificially-sweetened Beverage, Fruit Juice And Water Consumption.
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Many countries are introducing sugar sweetened beverages (SSBs) taxes and other policy measures to curb consumption. However, artificially sweetened beverages (ASBs) and fruit juices are being excluded from these policy measures. This may have unintended consequences for consumption behaviours and create other negative health outcomes. We will examine substitution effects of SSB policy on water, ASBs and fruit juice consumption, and make recommendations for public health policy.
My research aims to improve health care for back pain. First, I will conduct and summarise clinical trials to identify the best treatments for back pain. Second, I will develop data systems to check that the health care delivered is of the highest quality. Third, I will improve understanding of low back pain amongst the general public and health workers. Last, I will work with health services to develop better ways to deliver health services for back pain.
Partnering With Patients To Transform Practice And Policy For Improved Patient-centred Outcomes In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$3,292,932.00
Summary
Chronic kidney disease (CKD) is a major cause of death and imposes a substantial burden on individuals and the healthcare system worldwide. In partnership with patients, this project will establish and implement core outcomes and measures. Patient-centred trials will address the research priorities of patients across all stages of CKD including: preventing the progression of CKD, improving fatigue in patients on dialysis, and optimising life participation in kidney transplant recipients.
Transforming Approaches To Chronic Disease Prevention In Community Settings
Funder
National Health and Medical Research Council
Funding Amount
$2,738,220.00
Summary
Chronic disease is the leading cause of death in Australia. Research has identified a number of interventions to prevent chronic disease. However, most of these are impractical, difficult to implement and so have little impact in improving community health. In this research program I will generate evidence that is relevant for policy makers and practitioners, identifying effective interventions that can feasibly be delivered, and effective approaches to implement them in community settings.
Leaving No One Behind: Community-driven Approaches To Eliminate HIV In Australia
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Eliminating HIV from Australia is possible with effective HIV prevention methods like treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP). However there are inequities in our HIV response with declines of new infections in Australian-born men who have sex with men but not in overseas-born Australian men. This program uses crowdsourcing (sharing solutions from the community to eliminate HIV) and evaluates the value of the proposed solutions, to inform HIV policy.
Transforming Treatment Options And Delivery Of Care For Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$2,510,793.00
Summary
Osteoarthritis is highly prevalent and a leading cause of disability. Despite this burden, current management is frequently inappropriate and associated with enormous financial costs. This program of research leverages established resources and existing funding to investigate the key challenges for OA in the next decade, including 1) Further enhance the methods for disease modification trials and deploy novel trials, and 2) Optimise the delivery of care for those with extant disease.
The Impact Of Breast Density Notification In Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Breast density is an independent risk factor for breast cancer and it increases the risk of having a cancer missed during screening. Notifying women about their breast density has been endorsed as a way to combat this risk. However, the evidence to support breast density notification and recommendations for supplemental screening in the general population of women is far from clear. This research will provide critical new evidence to ensure that Australian women receive evidence-based care.