The fluid mechanics of dynamically constricted tubes in pulsatile flow. This project is aimed at advancing the fundamental understanding of flow instability, the transition to turbulence and the effect on wall shear stress, in a dynamically constricted tube flow. The project will provide the first accurately resolved experimental flow analysis, using tomographic particle imaging velocimetry and 3D laser doppler anemometry, conducted on a novel experimental model, and will resolve, for the first ....The fluid mechanics of dynamically constricted tubes in pulsatile flow. This project is aimed at advancing the fundamental understanding of flow instability, the transition to turbulence and the effect on wall shear stress, in a dynamically constricted tube flow. The project will provide the first accurately resolved experimental flow analysis, using tomographic particle imaging velocimetry and 3D laser doppler anemometry, conducted on a novel experimental model, and will resolve, for the first time, turbulence characteristics of the dynamic constriction, using direct numerical simulation with a novel moving boundary implementation. The outcomes will provide the key link between fluid mechanics and wall shear stress, allowing future progress to be made in elucidating the causes of cardiovascular disease.
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Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed ....Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed low-pressure experimental facilities. Benefits will be more accurate design guidance for efficient and robust flapping and rotary wing robotic vehicles for Mars and other space exploration that take advantage of the unique atmospheric conditions, and in placing Australia at the forefront of such design technology.Read moreRead less
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Studies On The Effects Of Endogenous And Exogenous Opioids In Modulating Exercise-induced Dyspnoea In People With Moderate / Severe Chronic Obstructive Pulmonary Disease (COPD). Two Double-blind Randomised, Placebo Controlled Trials.
Funder
National Health and Medical Research Council
Funding Amount
$197,086.00
Summary
There is evidence that morphine-like chemicals made by the body itself help reduce breathlessness. It is not clear whether this response is because of the effects of these morphine-like chemicals on the brain, in the lung or both. This study will help understand where these chemicals act to reduce breathlessness in people with emphysema during exercise. Subsequently, it will also help to understand whether small, regular doses of morphine safely further reduce breathlessness during exercise.
Thermal Optimisation of Gigascale Solar Photovoltaics. Large-scale solar photovoltaics are critical to decarbonising the global economy. Sun Cable is developing the world’s largest solar farm in the Northern Territory, and is considering deploying the 5B MAV solar array. At this scale, temperature-induced panel efficiency losses represent a major challenge that must be overcome through thermal performance optimisation. We will build sophisticated multiscale models to simulate and understand the ....Thermal Optimisation of Gigascale Solar Photovoltaics. Large-scale solar photovoltaics are critical to decarbonising the global economy. Sun Cable is developing the world’s largest solar farm in the Northern Territory, and is considering deploying the 5B MAV solar array. At this scale, temperature-induced panel efficiency losses represent a major challenge that must be overcome through thermal performance optimisation. We will build sophisticated multiscale models to simulate and understand the multiple interacting phenomena that cause panel heating, for the first time. This project will create the tools and know-how to optimise array design and solar farm development, delivering major efficiency gains and enhancing the viability of future gigascale solar projects.Read moreRead less
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Transition of thermal boundary layers on heated flat and curved surfaces. This project aims to study the laminar to turbulent transition of the thermal boundary layer (TBL). The state of the TBL determines the heat transfer rate and energy efficiency of natural convection heat exchangers and heat dissipation systems. The intended outcome is to understand the TBL’s transitional behaviour and develop effective strategies for stimulating TBL transition to enhance heat transfer. This project will de ....Transition of thermal boundary layers on heated flat and curved surfaces. This project aims to study the laminar to turbulent transition of the thermal boundary layer (TBL). The state of the TBL determines the heat transfer rate and energy efficiency of natural convection heat exchangers and heat dissipation systems. The intended outcome is to understand the TBL’s transitional behaviour and develop effective strategies for stimulating TBL transition to enhance heat transfer. This project will develop a high-resolution, low-cost and easy-to-implement three-dimensional volumetric flow measurement technique based on stereoscopic shadowgraph and use it to study the TBL transition. This technique should provide a powerful tool for fluid mechanics and heat transfer research.Read moreRead less
Turbulent mixing of a passive scalar. Turbulence is the usual state of fluid motion. This proposal will increase Australia's expertise in fundamental turbulence research, especially in the area of turbulent mixing, which is of major importance in many natural and engineering problems involving combustion, chemical reactions and pollution. A better knowledge of mixing at small scales will lead to more efficient combustion, savings in energy expenditure as well as a reduction in pollutant emiss ....Turbulent mixing of a passive scalar. Turbulence is the usual state of fluid motion. This proposal will increase Australia's expertise in fundamental turbulence research, especially in the area of turbulent mixing, which is of major importance in many natural and engineering problems involving combustion, chemical reactions and pollution. A better knowledge of mixing at small scales will lead to more efficient combustion, savings in energy expenditure as well as a reduction in pollutant emissions. Read moreRead less
An Integrated Health-sector Strategy To Combat COPD And Asthma In Vietnam: A Pragmatic Stepped Intervention Cluster Randomized Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,894,349.00
Summary
Chronic lung diseases are a major challenge for resource limited settings. In Vietnam, where smoking rates in males are around 50%, there is an urgent need for better strategies to prevent and treat chronic obstructive pulmonary disease (COPD) and asthma. We will perform a study of a low-cost integrated intervention including a health-system based smoking cessation program and the targeted use of proven therapy for COPD and asthma - inhaled corticosteroids - to reduce the burden of lung disease.