A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Advancing water pollution emissions modelling in cities of the future. Advancing water pollution emissions modelling in cities of the future. This project aims to advance stormwater pollution modelling and enhance its link with urban development. Management of stormwater pollution by industry often results in inadequate strategies and, crucially, sub-optimal financial investments. Since this is unlikely to improve in light of urban growth and climate change, addressing decade-old pollution model ....Advancing water pollution emissions modelling in cities of the future. Advancing water pollution emissions modelling in cities of the future. This project aims to advance stormwater pollution modelling and enhance its link with urban development. Management of stormwater pollution by industry often results in inadequate strategies and, crucially, sub-optimal financial investments. Since this is unlikely to improve in light of urban growth and climate change, addressing decade-old pollution modelling knowledge gaps and the lack of a multidisciplinary approach to stormwater pollution management is urgent. The anticipated outcome is a modelling tool which industry can use to manage stormwater pollution in changing cities through smarter and economic technology and policy.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Benefits Of Home-based Multidisciplinary Rehabilitation In Non Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$581,039.00
Summary
Lung cancer is the third leading cause of death in Australia. People with lung cancer experience a complex mix of symptoms that can provoke significant distress and impair physical function. This study aims to develop and test a home based exercise and self-management support program to increase function and physical activity levels, reduce levels of depression and improve quality of life of people with lung cancer.
Tackling Atmospheric Chemistry Grand Challenges in the Southern Hemisphere. The project aims to provide a southern hemisphere perspective on current challenges in atmospheric chemistry: air quality, oxidation capacity, stratospheric change, and chemistry–climate interactions. Australia’s geographic position in the relatively clean southern hemisphere allows a unique opportunity to study environments with limited human influence, an opportunity that has largely been lost in the more populous nort ....Tackling Atmospheric Chemistry Grand Challenges in the Southern Hemisphere. The project aims to provide a southern hemisphere perspective on current challenges in atmospheric chemistry: air quality, oxidation capacity, stratospheric change, and chemistry–climate interactions. Australia’s geographic position in the relatively clean southern hemisphere allows a unique opportunity to study environments with limited human influence, an opportunity that has largely been lost in the more populous northern hemisphere. The intended outcomes of the project include validated ground-based and satellite datasets for monitoring Australia’s air quality, improved atmospheric models for predicting future atmospheric change, and a deeper understanding of the processes driving atmospheric composition worldwide.Read moreRead less
Psychosocial Disability And Return To Work In Younger Stroke Survivors
Funder
National Health and Medical Research Council
Funding Amount
$511,216.00
Summary
Each year about 12,000 Australians of working age survive a stroke. These younger survivors have responsibility for generating an income or providing care for families and state that their main objective is to return to work for financial reasons and to help rebuild confidence and independence. This observational 3 year study will determine thefactors are associated with returning to work, improving the wellbeing of thousands of stroke survivors and their families using multivariate regression.
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.
Bushfire smoke and the relationship between human and landscape health. A team of landscape ecologists, environmental chemists and public health specialists will determine the ecological causes and adverse health effects of different levels of bushfire smoke in Darwin. Darwin is an ideal setting for this research because the only source of air pollution is the high incidence of controlled and uncontrolled bushfires during the dry season causing variable air quality: a preliminary study found a ....Bushfire smoke and the relationship between human and landscape health. A team of landscape ecologists, environmental chemists and public health specialists will determine the ecological causes and adverse health effects of different levels of bushfire smoke in Darwin. Darwin is an ideal setting for this research because the only source of air pollution is the high incidence of controlled and uncontrolled bushfires during the dry season causing variable air quality: a preliminary study found a link between smoke pollution levels and asthma. The findings of the proposed research will contribute to improved fire management practices to reduce injurious smoke pollution events and contribute to setting appropriate national air quality standards.Read moreRead less
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less