Can technology make communication in complex systems safer and more efficient? Evaluation of an electronic test management system in health care. In many industries poor communication has a major impact on safety; in health, missed test results have impacts ranging from inappropriate antibiotic therapy to missed cancer diagnoses. This research will evaluate new information technology which can improve health outcomes and communication between clinicians, laboratories and patients.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Stable water isotopic simulation and analysis to improve Earth System models and deliver better predictions of Australian water resource vulnerability. As Australia's challenges in environmental sustainability rival those anywhere on Earth, we must be clever in our diagnosis of susceptibility and insightful in proposed remedies. Climate change and variability have impacts on people and society that must be managed effectively whatever their causes. Of importance to Australia is the availabilit ....Stable water isotopic simulation and analysis to improve Earth System models and deliver better predictions of Australian water resource vulnerability. As Australia's challenges in environmental sustainability rival those anywhere on Earth, we must be clever in our diagnosis of susceptibility and insightful in proposed remedies. Climate change and variability have impacts on people and society that must be managed effectively whatever their causes. Of importance to Australia is the availability of water for drinking and agriculture. The new, interdisciplinary ARC network for Earth System Science provides models for novel and synergistic research such as naturally occurring water isotopes as a tool for improving predictive skill and confidence. We exploit these and leverage international programs to improve regional hydro-climate and water resource understanding in Australia.Read moreRead less
Closing the water cycle using land surface modelling, remote sensing and an Australian hydrological observatory. Australians live in the driest inhabited continent on Earth. Water supply and its variability have been constant problems throughout our history. This project will use space based satellites, sophisticated ground based instruments and advanced modelling tools to provide a 21st century characterisation of our nation's water resources.
New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will signific ....New Bayesian methodology for understanding complex systems using hidden Markov models and expert opinion, environmental, robotics and genomics applications. This project aims to merge four areas of intense international interest in describing complex systems: hidden Markov models and mixtures, semi-parametric and nonparametric approaches, true combination of expert opinion with data, and new Bayesian computational methods based on perfect sampling and particle sampling. The project will significantly contribute to statistical methodology and its ability to inform about real-world problems. A strong focus on applications to genomics, robotics and environmental modelling will bring immediate research and monetary benefit for industry. Expected outcomes include enhanced cross-disciplinary and international linkages, publications, industry-funded projects and highly trained graduates.Read moreRead less
Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping ....Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping sicker patients alive for longer, leading to increased clinical risk and more incidents. This project could save around 20% of the total cost of hospital operations by reducing lengths of stay, lowering re-admission rates and ensuring better deployment of clinical resources.Read moreRead less
Tackling Atmospheric Chemistry Grand Challenges in the Southern Hemisphere. The project aims to provide a southern hemisphere perspective on current challenges in atmospheric chemistry: air quality, oxidation capacity, stratospheric change, and chemistry–climate interactions. Australia’s geographic position in the relatively clean southern hemisphere allows a unique opportunity to study environments with limited human influence, an opportunity that has largely been lost in the more populous nort ....Tackling Atmospheric Chemistry Grand Challenges in the Southern Hemisphere. The project aims to provide a southern hemisphere perspective on current challenges in atmospheric chemistry: air quality, oxidation capacity, stratospheric change, and chemistry–climate interactions. Australia’s geographic position in the relatively clean southern hemisphere allows a unique opportunity to study environments with limited human influence, an opportunity that has largely been lost in the more populous northern hemisphere. The intended outcomes of the project include validated ground-based and satellite datasets for monitoring Australia’s air quality, improved atmospheric models for predicting future atmospheric change, and a deeper understanding of the processes driving atmospheric composition worldwide.Read moreRead less
Towards a science of high dimensional computation. This project aims to establish scientifically precise methods for high dimensional problems - methods that are mathematically rigorous, empirically tested, and carefully tailored to specific modern applications across physics, environment, and finance. This project expects to generate new knowledge in the area of high dimensional computation and to develop technological innovations in key areas of science and industry. Expected outcomes of this ....Towards a science of high dimensional computation. This project aims to establish scientifically precise methods for high dimensional problems - methods that are mathematically rigorous, empirically tested, and carefully tailored to specific modern applications across physics, environment, and finance. This project expects to generate new knowledge in the area of high dimensional computation and to develop technological innovations in key areas of science and industry. Expected outcomes of this project include enhanced international and interdisciplinary collaborations, and significant publications and presentations in international forums. These technological advancements will help boost Australia’s position as a world leader in creativity and innovation.Read moreRead less
Impact of redox condition on emerging contaminants fate. This project aims to improve our ability to predict the environmental drivers that control the fate of contaminants of emerging concern in the subsurface. Emerging contaminants are a concern due to their potential negative ecosystem and health outcomes. Prediction of their environmental fate will be of benefit as it will help ensure the safety of our drinking water sources and ensure that water sources are fit for purpose. With increasing ....Impact of redox condition on emerging contaminants fate. This project aims to improve our ability to predict the environmental drivers that control the fate of contaminants of emerging concern in the subsurface. Emerging contaminants are a concern due to their potential negative ecosystem and health outcomes. Prediction of their environmental fate will be of benefit as it will help ensure the safety of our drinking water sources and ensure that water sources are fit for purpose. With increasing pressure on our precious water resources prediction of the risks to this resource is essential. Expected outcomes are of significance as they will include a much improved ability to predict and control the ultimate fate of emerging contaminants in our water sources.Read moreRead less
Investigation into on-road vehicle rollovers using a combined rigid and flexible multibody model. Rollover propensity is one of the major safety indicators of vehicles. In-depth understanding of the causes and mechanisms of vehicle rollovers and the availability of advanced design and simulation tools will greatly assist the automotive industry in improving vehicle safety and consequently enhance the industry's competitiveness in the international marketplace. The developed knowledge would also ....Investigation into on-road vehicle rollovers using a combined rigid and flexible multibody model. Rollover propensity is one of the major safety indicators of vehicles. In-depth understanding of the causes and mechanisms of vehicle rollovers and the availability of advanced design and simulation tools will greatly assist the automotive industry in improving vehicle safety and consequently enhance the industry's competitiveness in the international marketplace. The developed knowledge would also benefit aeronautical, ship building and military industries which are generally well-equipped to absorb new technology and seek a competitive edge. The wide community would benefit by potentially reduced death rates and fatal injuries caused by rollover crashes, and through increased employment in industry. Read moreRead less