Resolving the Genetics of Grain Pigmentation Traits in Rice . New critical knowledge will enable future breeding of quality black rice cultivars that can exploit the high UV Australian growing environment to enable domestic production of high-value, healthy black rice. The demand for functional foods with health benefits, including black rice, is increasing both domestically and internationally. The concentration of key functional compounds in black rice may be increased by growing optimised cul ....Resolving the Genetics of Grain Pigmentation Traits in Rice . New critical knowledge will enable future breeding of quality black rice cultivars that can exploit the high UV Australian growing environment to enable domestic production of high-value, healthy black rice. The demand for functional foods with health benefits, including black rice, is increasing both domestically and internationally. The concentration of key functional compounds in black rice may be increased by growing optimised cultivars under high-UV radiation, making Australia well placed to produce the highest quality black rice. Utilising a unique genetic resource this project will resolve how the interaction between crop genetics and the growing environment drives the concentration of functional compounds in black rice. Read moreRead less
Characterising inheritance patterns of whole genome DNA methylation. This project aims to characterise epigenetic diversity and inheritance patterns in whole genome sequencing data from a unique human population. The project will employ the well-characterised Norfolk Island genetic isolate, cost-effective whole genome bisulphite sequencing technologies and advanced bioinformatics pipelines and statistical models. It will involve cross-discipline collaboration between human geneticists, epigeneti ....Characterising inheritance patterns of whole genome DNA methylation. This project aims to characterise epigenetic diversity and inheritance patterns in whole genome sequencing data from a unique human population. The project will employ the well-characterised Norfolk Island genetic isolate, cost-effective whole genome bisulphite sequencing technologies and advanced bioinformatics pipelines and statistical models. It will involve cross-discipline collaboration between human geneticists, epigeneticists, statistical geneticists and bioinformaticians. This project will advance our understanding of the interaction of genetics and epigenetics and their relationship to diversity and inheritance in humans.Read moreRead less
Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key featur ....Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key feature in biology, which relates to dissecting the complex mechanism of association and interaction. The proposed statistical model implemented in a context of a novel design based on multiple GWAS data sets is a paradigm shifting-tool with applications to multiple industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101210
Funder
Australian Research Council
Funding Amount
$451,634.00
Summary
Deciphering molecular genetic mechanisms underlying chromatin interactions. This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromati ....Deciphering molecular genetic mechanisms underlying chromatin interactions. This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromatin pairs; ii) Comperehensive maps of regulatory interactomes in 61 tissues & cells, which will provide a roadmap for interpreting & prioritising noncoding variants.
This should provide significant benefit to Australia's capacity for cutting-edge genomics research through fundamental understanding of gene regulation mechanism.Read moreRead less
Measuring uncertainty in global housing markets and its risk to Australia. This project aims to develop and construct a measure of systemic risk for the national real-estate markets in Australia, and its main trading partners, namely China, Japan, New Zealand, United Kingdom and United States of America. Recently developed methodology will be used to investigate how real estate risks migrate across these countries over time, and during periods of financial turbulence. This methodology is intende ....Measuring uncertainty in global housing markets and its risk to Australia. This project aims to develop and construct a measure of systemic risk for the national real-estate markets in Australia, and its main trading partners, namely China, Japan, New Zealand, United Kingdom and United States of America. Recently developed methodology will be used to investigate how real estate risks migrate across these countries over time, and during periods of financial turbulence. This methodology is intended to be employed as part of a market stability surveillance program and for assessing the impact of real-estate risk on the overall economy. Early detection of the onset of future housing bubble collapses would be of significant benefit to policy makers, Australia’s trading partners, the real estate industry and ultimately home buyers.Read moreRead less
Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave sec ....Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave security scanners. This should provide benefits such as the capability to scan a crowd without a checkpoint, which will have the potential to improve security in public places.Read moreRead less
Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statis ....Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statistical methods provide the opportunity to close this gap. The outcome will be identification of many genomic variants causing variation in complex traits. This will benefit scientific understanding of complex traits and the ability to predict traits for individuals from their genome sequence.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100052
Funder
Australian Research Council
Funding Amount
$2,107,500.00
Summary
Breakthrough methods for noncommutative calculus. This project aims to solve hard, outstanding problems which have impeded our ability to progress in the area of quantum or noncommutative calculus. Calculus has provided an invaluable tool to science, enabling scientific and technological revolutions throughout the past two centuries. The project will initiate a program of collaboration among top mathematical researchers from around the world and bring together two separate mathematical areas int ....Breakthrough methods for noncommutative calculus. This project aims to solve hard, outstanding problems which have impeded our ability to progress in the area of quantum or noncommutative calculus. Calculus has provided an invaluable tool to science, enabling scientific and technological revolutions throughout the past two centuries. The project will initiate a program of collaboration among top mathematical researchers from around the world and bring together two separate mathematical areas into a powerful new set of tools. The outcomes from the project will impact research at the forefront of mathematical physics and other sciences and enhance Australia’s reputation and standing.Read moreRead less
A Functional Analysis of the Hypoelliptic Laplacian. Strike a bell, a sphere, or any geometrical object, and it rings. The frequencies of ringing are the mathematical spectrum, which encodes deep secrets about the shape of the object. The spectrum of the hypoelliptic laplacian is known to carry deep truths in mathematics and physics, but it remains difficult to understand. We propose a new analytic foundation, which will replace the so far non-analytical ad hoc approach, and make accessible many ....A Functional Analysis of the Hypoelliptic Laplacian. Strike a bell, a sphere, or any geometrical object, and it rings. The frequencies of ringing are the mathematical spectrum, which encodes deep secrets about the shape of the object. The spectrum of the hypoelliptic laplacian is known to carry deep truths in mathematics and physics, but it remains difficult to understand. We propose a new analytic foundation, which will replace the so far non-analytical ad hoc approach, and make accessible many new results. It is key to better understanding differential equations which lie at the boundary between quantum mechanics and the classical world. This will pave the way for Australian leadership in a new century of differential equations and geometry, and training of young mathematicians.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100840
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Monitoring financial bubbles using high-frequency data. This project aims to develop an econometric procedure for monitoring speculative behaviour, often labelled as bubbles, in financial markets. There has been widespread recognition that financial speculation can inflict harm on the real economy. Crises or recessions are often preceded by excessive asset market speculation. This project will utilise intraday information for bubble detection and address major technical challenges arising from h ....Monitoring financial bubbles using high-frequency data. This project aims to develop an econometric procedure for monitoring speculative behaviour, often labelled as bubbles, in financial markets. There has been widespread recognition that financial speculation can inflict harm on the real economy. Crises or recessions are often preceded by excessive asset market speculation. This project will utilise intraday information for bubble detection and address major technical challenges arising from high-frequency financial data. It is expected to significantly improve the speed and accuracy of bubble detection, thereby providing more timely and precise warning alerts for investment decisions, market surveillance and policy action.Read moreRead less