A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conduct ....A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conductance properties of the channel. Accurately
determining these relationships provides a pathway to developing cures
for many neurological, cardiac, and muscular diseases.
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ARC Centre of Excellence for Engineered Quantum Systems. This Centre aims to build sophisticated quantum machines to harness the quantum world for the future health, economy, environment and security of Australian society. It intends to pioneer the designer quantum materials, engines and imaging systems at the heart of these machines. It also solves the most challenging research problems at the interface of basic quantum physics and engineering. The Centre will work with industry partners to tra ....ARC Centre of Excellence for Engineered Quantum Systems. This Centre aims to build sophisticated quantum machines to harness the quantum world for the future health, economy, environment and security of Australian society. It intends to pioneer the designer quantum materials, engines and imaging systems at the heart of these machines. It also solves the most challenging research problems at the interface of basic quantum physics and engineering. The Centre will work with industry partners to translate these research discoveries into practical applications and devices. It will train scientists in research, innovation, and entrepreneurship, which is expected to affect Australia’s high-tech economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882792
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
High Power Laser, Test Masses, Digital Control System and Vacuum System for High Optical Power Interferometry Experiments. Gravitational waves are expected to offer humanity a completely new spectrum with which to study the Universe. Australia has been a pioneer in the quest to open up this new spectrum. This project will allow Australia to play a key role in a world-wide project which aims for the first time to enable gravitational waves to be detected from black holes and neutron stars through ....High Power Laser, Test Masses, Digital Control System and Vacuum System for High Optical Power Interferometry Experiments. Gravitational waves are expected to offer humanity a completely new spectrum with which to study the Universe. Australia has been a pioneer in the quest to open up this new spectrum. This project will allow Australia to play a key role in a world-wide project which aims for the first time to enable gravitational waves to be detected from black holes and neutron stars throughout the universe. It will give Australia access to developed technologies, and will be a major boost to physical science research and education.Read moreRead less
The effect of de-gassing on the dispersion and stability of emulsions and colloidal solutions. Although it is widely accepted that oil and water will not mix, the reverse has recently been found to occur (by the applicant) under the unusual conditions of complete de-gassing. This discovery has opened up new areas for investigation and for the development of new processes and products. Hydrocarbon oils and hydrophobic powders can now be readily dispersed in water without the use of additives. Ho ....The effect of de-gassing on the dispersion and stability of emulsions and colloidal solutions. Although it is widely accepted that oil and water will not mix, the reverse has recently been found to occur (by the applicant) under the unusual conditions of complete de-gassing. This discovery has opened up new areas for investigation and for the development of new processes and products. Hydrocarbon oils and hydrophobic powders can now be readily dispersed in water without the use of additives. However, the mechanisms involved have not yet been elucidated and it is the aim of this project to understand the process and develop potential commercial applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989374
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenera ....South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenerate diseases (e.g. Parkinson's disease) osteoarthritis, inflammation, cardiac diseases and synthetic approaches to anticancer and other drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100009
Funder
Australian Research Council
Funding Amount
$455,000.00
Summary
Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins ....Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins a modern, technically advanced society. With this facility Australian researchers will lead the world in the fabrication of optical crystalline devices for a broad range of industrial and research applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100129
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Equipment and instrumentation for breaking the quantum measurement barrier. This equipment will support Australia's partnership in the international effort to detect gravitational waves, which would allow the first direct observation of black holes and mark the beginning of exploration of the gravitational wave spectrum.