TOWARDS A COMPLETE DESCRIPTION OF HOW ENZYMES WORK: development of simulation methods and protocols, blind test predictions, and experimental validation. Enzymes catalyze quite fantastic chemistry under mild physiological conditions. Many special chemical concepts (such as "transition-state stabilization" and "entropy-enthalpy compensation") proposed to explain these powers are unnecessary. Uniquely for a catalyst, these powers are integral to the structure, properties and dynamics of the protei ....TOWARDS A COMPLETE DESCRIPTION OF HOW ENZYMES WORK: development of simulation methods and protocols, blind test predictions, and experimental validation. Enzymes catalyze quite fantastic chemistry under mild physiological conditions. Many special chemical concepts (such as "transition-state stabilization" and "entropy-enthalpy compensation") proposed to explain these powers are unnecessary. Uniquely for a catalyst, these powers are integral to the structure, properties and dynamics of the protein, as constrained and selected by evolution. The question is how do they work? Answering this requires energetic and thermodynamic analysis beyond current experimental techniques, but accessible by computer simulation. We aim to develop a robust toolkit of simulation methods and protocols, blind test them by predicting the mechanism of a new enzyme, with followup experimental validation.
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Importance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms. The research will contribute to the development of biomolecular simulation in Australia by demonstrating its potential to complement experiment, and also promote the effective use of APAC (Australian national supercomputer facilities) resources by providing advanced programs and computational protocols for other researchers. It will assist the diffusion of computational biology technology i ....Importance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms. The research will contribute to the development of biomolecular simulation in Australia by demonstrating its potential to complement experiment, and also promote the effective use of APAC (Australian national supercomputer facilities) resources by providing advanced programs and computational protocols for other researchers. It will assist the diffusion of computational biology technology into industrial applications such as rational drug design and protein engineering, as, for example, in our associated Linkage project grant, and provide novel insights into protein engineering and other sorts of design, which transcend concepts currently used in biomimetic chemistry.Read moreRead less
An integrated approach towards the development of new generation RF/microwave dielectric materials. The ultimate aim of this project is to rationally design and optimize new types of environmentally-sustainable, cost-effective and high performance microwave dielectric materials and devices for advanced information and communication technology (ICT) applications. This is a designated National Research Priority area. Our fundamental understanding of dielectric materials and their properties will b ....An integrated approach towards the development of new generation RF/microwave dielectric materials. The ultimate aim of this project is to rationally design and optimize new types of environmentally-sustainable, cost-effective and high performance microwave dielectric materials and devices for advanced information and communication technology (ICT) applications. This is a designated National Research Priority area. Our fundamental understanding of dielectric materials and their properties will be enhanced considerably by working on this project. Further, we will promote the relationship between the fundamental science of polar crystalline materials and practical applications. If successful, the results will enhance Australia's capacity and standing in this highly competitive area. Read moreRead less
Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measure ....Next Generation Planar Tellurite Waveguides. The project provides the basis for the production of new high technology photonic products in Australia, the availability of at least one new unique facility for future scientific endeavour, and the generation of skillsets new to Australia. New IP will also be developed during the project. A successful outcome could also ultimately result in new products offering, for example, enhanced National Security through the Defence applications, better measurements of atmospheric contaminants through the sensing route, and more advanced telecommunications services at lower cost for citizens and businesses, and for lower operating costs for service providers.
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Defect-induced luminescence from ion-implanted silicon: Towards silicon photonics applications. This project focusses on advanced materials science, photonics and innovative silicon optical devices that have potential for contributing to information and communications technologies, areas where Australia has considerable expertise and investment. Specifically, national benefit will be derived from breakthroughs in fundamental science and intellectual property.
A high performance and environment-friendly piezoelectric detector platform for biosensor applications. The development of high performance, lead-free, piezoelectric films and their incorporation into devices is rapidly becoming an urgent task as a result of recent legislation banning the use of lead in electronic components. The successful development of piezoelectric biosensors, as proposed in this project, has numerous potential benefits including the prospect of rapid and cheap biosensor dev ....A high performance and environment-friendly piezoelectric detector platform for biosensor applications. The development of high performance, lead-free, piezoelectric films and their incorporation into devices is rapidly becoming an urgent task as a result of recent legislation banning the use of lead in electronic components. The successful development of piezoelectric biosensors, as proposed in this project, has numerous potential benefits including the prospect of rapid and cheap biosensor devices as well as an environment-friendly, sensitive and real time solution for on-site drug, chemical and biological sensing. Successful development of the latter would provide immediate benefit in the areas of national security, food safety as well as in environmental and health monitoring. Read moreRead less
Creation of novel photonic and nanostructured materials by ablation of solids with ultra-fast lasers. This project will study of the production of technologically important thin film materials and nanostructured materials using our patented ultra-fast pulsed laser deposition process. Thin film materials required for future applications in photonics will be a priority. In addition ultra-fast pulsed laser deposition can be used to create nanopartilces and mechanisms affecting the growth of these ....Creation of novel photonic and nanostructured materials by ablation of solids with ultra-fast lasers. This project will study of the production of technologically important thin film materials and nanostructured materials using our patented ultra-fast pulsed laser deposition process. Thin film materials required for future applications in photonics will be a priority. In addition ultra-fast pulsed laser deposition can be used to create nanopartilces and mechanisms affecting the growth of these materials will be studied. The project therefore falls into two priority areas: photon science and nanotechnology. Outcomes in addition to new knowledge will include materials and processes with commercial potential.Read moreRead less
Enabling Technologies for Structural Genomics. New technologies will be developed to save time, money and effort in rapid preparation of protein samples for structural genomics. Systems will be devised for preparing sufficient isotope-labelled proteins for nuclear magnetic resonance spectroscopy without using living organisms, for efficiently identifying points at which proteins can be broken into smaller fragments with the right properties, and for joining the ends of proteins and peptides toge ....Enabling Technologies for Structural Genomics. New technologies will be developed to save time, money and effort in rapid preparation of protein samples for structural genomics. Systems will be devised for preparing sufficient isotope-labelled proteins for nuclear magnetic resonance spectroscopy without using living organisms, for efficiently identifying points at which proteins can be broken into smaller fragments with the right properties, and for joining the ends of proteins and peptides together to make them much more stable. This combination of technologies are widely applicable to current problems in protein chemistry, molecular biology, functional genomics and the medical sciences.Read moreRead less
Ordered Semiconductor Nanostructures for Electronics and Photonics Applications. This research program aims to develop innovative concepts and technologies to manipulate atoms to control size, shape and position of nanostructures in order to control their electronic and optical properties. The research program will produce important innovations and advance Australian knowledge in electronics, photonics, communications and computer technologies. This research will allow Australia to become a si ....Ordered Semiconductor Nanostructures for Electronics and Photonics Applications. This research program aims to develop innovative concepts and technologies to manipulate atoms to control size, shape and position of nanostructures in order to control their electronic and optical properties. The research program will produce important innovations and advance Australian knowledge in electronics, photonics, communications and computer technologies. This research will allow Australia to become a significant player in nanotechnology and has the potential for the development of patentable technologies of immense interest for high technology industries.Read moreRead less
Integrated magneto-optic waveguide materials and devices. We aim to develop chalcogenide glass films for fabricating integrated waveguide magneto-optic (MO) devices as a radical alternative to the use of crystalline MO materials that have proven difficult to manufacture in integrated form. Using our ultra-fast pulsed laser deposition (UFPLD) technique we will produce a wide range of chalcogenide glass compositions through combinatorial materials synthesis and assess them for magneto-optic activ ....Integrated magneto-optic waveguide materials and devices. We aim to develop chalcogenide glass films for fabricating integrated waveguide magneto-optic (MO) devices as a radical alternative to the use of crystalline MO materials that have proven difficult to manufacture in integrated form. Using our ultra-fast pulsed laser deposition (UFPLD) technique we will produce a wide range of chalcogenide glass compositions through combinatorial materials synthesis and assess them for magneto-optic activity. UFPLD will also be used to deposit high optical quality films for device prototyping. We will design and fabricate prototype MO components which are essential, but currently unavailable, for use as optical isolators in integrated optics.Read moreRead less