Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project ha ....Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project have been used previously to synthesise the anti-cancer metabolite roseophilin. The results of this project will ensure that there are many more similar success stories in the pharmaceutical and biotechnology industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100015
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mamm ....Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mammalian pests and enhancing wood quality. In pharmaceutics, improved treatments for asthma are expected. This facility will provide the infrastructure essential for many researchers to maintain internationally competitive profiles in their areas and continue to offer postgraduate training and postdoctoral opportunities.Read moreRead less