Promoting Upper Limb Recovery After Stroke In People With Severe Paresis.
Funder
National Health and Medical Research Council
Funding Amount
$348,948.00
Summary
Stroke survivors with severe arm disability have poor potential for functional recovery. Yet, an incomplete understanding of indicators of good potential currently dictate clinical decisions concerning referral to rehabilitation and therapy provision. The proposed research aims to characterise the dynamic capacity of the severely damaged brain to recover. This research will provide the foundations for more personalized health care options and extend our understanding of this growing cohort.
Bioresponsive Nanocarriers For Controlled And Targeted Delivery To Efficiently Treat Inflammatory Bowel Disease (IBD)
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Despite considerable progress in treatment of Inflammatory Bowel Diseases, current treatments suffer from many disadvantages such as side effects, lack of efficacy in many patients, and development of drug dependence. Using state of art nanotechnology, novel nanoparticles will be developed to enhance the delivery to the intestine and efficacy of Budesonide (an anti-inflammatory steroid). This research promises to find safer and more effective ways to treat these diseases.
Improving The Therapeutic Use Of Anti-infective Agents: Application Of Pharmacometrics For Rational Dosing Regimen Design
Funder
National Health and Medical Research Council
Funding Amount
$313,390.00
Summary
There is no field of medicine in which the individualisation of medicines is more important than in infectious diseases – appropriate doses must be administered to maximise efficacy and to minimise side effects and the emergence of drug-resistance. This fellowship will use the emerging science of pharmacometrics to investigate factors contributing to the variability in response to anti-infective medications and to optimise dosing regimens for the best use of these drugs in clinical practice.
Localising Epileptic Discharges In The Brain Using Non-invasive Electro-magnetic Signal Analysis In Patients With Difficult-to-control Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$179,782.00
Summary
Epilepsy is a leading cause of chronic morbidity in Australia. A fundamental problem in clinical practice is the accurate identification of the 'hotspot' zone in the brain that is generating epileptic discharges. These discharges can be detected non-invasively (over the scalp) and analysed with electro-encephalographic and magneto-encephalographic source localisation (EMSL) techniques. EMSL is not used in routine clinical practice because we await a large scale prospective study (the aim of this ....Epilepsy is a leading cause of chronic morbidity in Australia. A fundamental problem in clinical practice is the accurate identification of the 'hotspot' zone in the brain that is generating epileptic discharges. These discharges can be detected non-invasively (over the scalp) and analysed with electro-encephalographic and magneto-encephalographic source localisation (EMSL) techniques. EMSL is not used in routine clinical practice because we await a large scale prospective study (the aim of this proposal).Read moreRead less
Spatial Coding In The Primate Cortex During Eye Movements.
Funder
National Health and Medical Research Council
Funding Amount
$428,720.00
Summary
Every time we move our eyes, objects in the world change their positions on the retina, yet to us, their positions remain perceptually unchanged. This project seeks to understand how neurons in the primate brain combine visual input with signals about eye position to construct this stable representation of external space. The findings will help us understand and-or rehabilitate a host of nervous system dysfunctions, including schizophrenia, stroke, and paraplegia.
Investigation Of 5-methylcytosine And MicroRNA Function In Eukaryotic RNA
Funder
National Health and Medical Research Council
Funding Amount
$311,991.00
Summary
It is hypothesised that 5-methylcytosine in RNA represents a novel regulatory code affecting transcriptome utilisation in ways currently hidden from view. To unravel this code and its (patho)- physiological role(s), this study proposes to generate and interpret comprehensive transcriptome-scale maps of 5-methylcytosine in a range of cellular contexts chosen to reveal links to cellular differentiation, growth, and malignant transformation.