The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
Preventing Child Internalising Problems: Follow Up Of A Population-based Randomised Trial Through Middle Childhood.
Funder
National Health and Medical Research Council
Funding Amount
$472,604.00
Summary
Many Australians suffer with internalising problems (anxiety, depression). They affect 1 in 7 school age children, impacting peer relations, school engagement and later mental health. Inhibited temperament (fearfulness, withdrawal) places children at risk. In 2010-14 we conducted a randomised prevention trial, screening preschoolers for inhibition and offering the Cool Little Kids parenting group program to those affected. We are now following families in this trial in mid-childhood (age 7-10).
Assertive Care: A Randomised Trial To Reduce Cardiovascular Risk For People With Severe Mental Illness
Funder
National Health and Medical Research Council
Funding Amount
$1,487,357.00
Summary
The physical health of people with severe mental illness is at crisis point. People die 15-20 years earlier than the general population from cardiovascular diseases that are preventable. Treatments do exist but routine identification is not happening and people with severe mental illness are missing out. Our assertive care intervention will identify, assess, treat, and follow up to reduce cardiovascular risk in severe mental illness and improve health outcomes.
Improving Outcomes For Children With ADHD: Mapping Developmental Trajectories And Developing Targeted Interventions
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Attention deficit hyperactivity disorder (ADHD) is one of the most common mental health disorders affecting young people in Australia. My research program aims to generate new knowledge to inform clinical practice for children with ADHD including: 1) long-term outcomes and key predictors of outcomes; and 2) novel treatments to improve the lives of children and families. Growth of my research program is feasible and underpinned by existing platforms including numerous NHMRC-funded studies.
Wernicke-Korsakoff syndrome is a common and frequently undiagnosed neurological disease due to thiamine deficiency. The condition leads to cognitive and neurological disability and mostly affects people with alcohol dependence. Wernicke-Korsakoff syndrome is eminently treatable with thiamine, although we have insufficient knowledge regarding the best dose of thiamine to treat the condition. This project proposes two controlled trials to evaluate treatment effectiveness of thiamine for Wernicke-K ....Wernicke-Korsakoff syndrome is a common and frequently undiagnosed neurological disease due to thiamine deficiency. The condition leads to cognitive and neurological disability and mostly affects people with alcohol dependence. Wernicke-Korsakoff syndrome is eminently treatable with thiamine, although we have insufficient knowledge regarding the best dose of thiamine to treat the condition. This project proposes two controlled trials to evaluate treatment effectiveness of thiamine for Wernicke-Korsakoff syndrome.Read moreRead less
A Randomised Controlled Trial Of A Mindfulness Intervention For Men With Advanced Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$729,841.00
Summary
Approximately 22,000 Australian men alive today have advanced prostate cancer. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress and poorer quality of life, and have an increased risk of suicide. This study will trial a remote access mindfulness-based cognitive therapy intervention aimed at improving mental health outcomes and wellbeing for men with advanced prostate cancer.
Reducing Suicide Ideation: A Randomised Controlled Trial Of A Novel Web Intervention
Funder
National Health and Medical Research Council
Funding Amount
$451,163.00
Summary
Suicidal ideation is experienced by almost 400,000 Australian adults. Many of them are reluctant to seek help for various reasons, whilst early intervention is important. The internet provides an opportunity to engage with individuals at risk of suicide and to offer evidence based, 24/7 prevention programs. This project aims to implement and test a web-based self-help intervention designed to reduce suicidal ideation.
Suicide is the most common cause of death in Australians aged 15-44. This ‘Centre for Research Excellence in Suicide Prevention’ aims to bring together leading experts in Australia and New Zealand to undertake the research work needed to determine the best way to deliver interventions to those at risk, to develop better understanding of the complex pathways that lead to suicide, to encourage help seeking and to prioritise which programs and services should be financially supported by Government.
Technology And Innovation In The Delivery Of Efficient, Effective Treatments For Comorbid Conditions
Funder
National Health and Medical Research Council
Funding Amount
$407,140.00
Summary
Treatment for co-occurring depression and alcohol/other drug use is difficult to access, due to a range of individual and service-level problems. This proposal will build on significant Australian research into psychological treatments for co-occurring problems, by developing and determining the most beneficial, flexible, cost effective models of treatment for these increasingly prevalent problems, regardless of location and ability to access treatment services.