Dietary Protein-induced DNA Damage In Colon And Consequences For Colorectal Oncogenesis
Funder
National Health and Medical Research Council
Funding Amount
$604,797.00
Summary
This research will explore the effects of dietary protein on genetic damage to cells lining the large bowel and risk of developing colorectal cancer. We will determine the degree and type of DNA damage resulting from increased protein, the cellular response to this DNA damage, whether it increases risk for developing bowel cancer and whether it can be minimised by other foods in both an animal model and humans.
Next-generation technology for determining fitness-for-use of starches in cereal grains. The project will deliver a new methodology to characterize starch-containing materials such as grains. This will provide the first tools to readily measure the full size distribution of starch in industry laboratories, giving far more information than is currently accessible. The data will be extremely sensitive to structural characteristics associated with desirable end-use properties. The new process will ....Next-generation technology for determining fitness-for-use of starches in cereal grains. The project will deliver a new methodology to characterize starch-containing materials such as grains. This will provide the first tools to readily measure the full size distribution of starch in industry laboratories, giving far more information than is currently accessible. The data will be extremely sensitive to structural characteristics associated with desirable end-use properties. The new process will enable conventional instrumentation methodology to be re-engineered to better select starch-containing materials. This will enable superior targeting and processing of materials for improved products in human nutrition, animal feed and manufactured goods such as biodegradable plastics.Read moreRead less
Modelling soft filled viscoelastic solids. Wheat flour doughs are made in vast quantities daily, and improvements in processing, especially in sheeting (rolling) and extrusion are needed. To enable this we will create a novel mathematical description of the material which will be useful for predicting the shapes of processed products. Wheat breeding cycles can be shortened by using the model rheological parameters, since baking quality is closely linked to dough rheology. A number of Australian ....Modelling soft filled viscoelastic solids. Wheat flour doughs are made in vast quantities daily, and improvements in processing, especially in sheeting (rolling) and extrusion are needed. To enable this we will create a novel mathematical description of the material which will be useful for predicting the shapes of processed products. Wheat breeding cycles can be shortened by using the model rheological parameters, since baking quality is closely linked to dough rheology. A number of Australian wheats will be considered and their rheologies will be compared.Read moreRead less
Experimental and Numerical Investigation of Granular Flow in Hoppers. Handling and processing of bulk solids such as coal and metal ores perform a key function in many industries, and hoppers are the most common devices for storage and discharge of granular materials in this field. The proper design of this equipment is very important. This project provides a systematic investigation of granular flow in hoppers, which is essential in order to avoid structure failures and associated costs. It wil ....Experimental and Numerical Investigation of Granular Flow in Hoppers. Handling and processing of bulk solids such as coal and metal ores perform a key function in many industries, and hoppers are the most common devices for storage and discharge of granular materials in this field. The proper design of this equipment is very important. This project provides a systematic investigation of granular flow in hoppers, which is essential in order to avoid structure failures and associated costs. It will lead to a fundamental understanding of relevant industrial processes, improvement of their efficiency, and hence improved competitiveness of Australian mining/mineral/metallurgical industries.Read moreRead less
Establishing the relations between starch nano- and mesostructure and macroscopic physical properties. Starch is the major energy component within human diets, and the most abundant polymer that can be readily extracted from annual crop plants, leading to many actual and potential industrial applications. There are major opportunities to optimise the nutritional value of starches in the human diet, and to enhance the properties of extracted starches as renewable alternatives to petrochemical pol ....Establishing the relations between starch nano- and mesostructure and macroscopic physical properties. Starch is the major energy component within human diets, and the most abundant polymer that can be readily extracted from annual crop plants, leading to many actual and potential industrial applications. There are major opportunities to optimise the nutritional value of starches in the human diet, and to enhance the properties of extracted starches as renewable alternatives to petrochemical polymers. This project will open up our understanding of the structure of starch polymers and show how this relates to important properties such as enzyme digestibility rates, leading to new opportunities for public health and commercial benefits.Read moreRead less
In vitro evolution of more thermostable dextranases for the Australian sugar industry. Dextrans are polysaccharides that adversely affect the productivity of sugarcane mills. The Australian sugar industry currently imports dextranases to deal with this problem but they are not heat stable so the mills have run at lower temperatures than optimal. We have isolated dextranases from thermophilic microorganisms and aim to improve their performance by generating superior heat-stable dextranases using ....In vitro evolution of more thermostable dextranases for the Australian sugar industry. Dextrans are polysaccharides that adversely affect the productivity of sugarcane mills. The Australian sugar industry currently imports dextranases to deal with this problem but they are not heat stable so the mills have run at lower temperatures than optimal. We have isolated dextranases from thermophilic microorganisms and aim to improve their performance by generating superior heat-stable dextranases using in vitro evolution, creating new activity levels by random mutation and recombination. The research will be significant in providing novel enzymes for domestic use, allowing import substitution and an outcome will be the development of a product with export potential.
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Seeing the discrete in a continuum: an integrated numerical-rheological-experimental approach towards high resolution micromechanical continuum models of granular media. Processes involving granular materials are complex and rarely reach more than 60% of the design capacity, due to inadequate understanding of granular rheology. The short term benefits of the proposed project are: improved insights on the rheology of granular media; experimentally validated micromechanical constitutive models ....Seeing the discrete in a continuum: an integrated numerical-rheological-experimental approach towards high resolution micromechanical continuum models of granular media. Processes involving granular materials are complex and rarely reach more than 60% of the design capacity, due to inadequate understanding of granular rheology. The short term benefits of the proposed project are: improved insights on the rheology of granular media; experimentally validated micromechanical constitutive models with unmatched predictive capabilities; modelling techniques in the analysis of multiscale processes, germane to the Science of Complex Materials. The long term benefits are models of the required reliability for computer-aided design, production and management of particulate systems. These simulation tools will enhance Australia's competitive edge in the multi-billion dollar particulate and geotechnical industries.Read moreRead less