Reverse Or Anatomical (replacement) For Painful Shoulder Osteoarthritis: Differences Between Interventions -Aus
Funder
National Health and Medical Research Council
Funding Amount
$1,540,874.00
Summary
Shoulder osteoarthritis is common in older adults, causing severe pain and making daily life difficult. Shoulder replacement is an effective treatment - it replaces the damaged joint with metal and plastic implants. Two types of shoulder replacement exist, but the best option is uncertain as they have not been compared in randomised trials. We will produce evidence about the benefits, harms and cost-effectiveness of each shoulder surgery to enable patients to receive the best type of surgery.
Mental Health Promotion And Intervention Program In The Australian Context: MINDUP Australia
Funder
National Health and Medical Research Council
Funding Amount
$421,779.00
Summary
MINDUP Australia aims to address poor mental health and elevated suicide risk in the construction, health and ICT sectors by contributing to the monitoring and evaluation of the European MINDUP workplace intervention. In addition, MINDUP Australia will enhance and extend the European MINDUP project by implementing a cluster randomised controlled trial within the construction industry in Australia. The trial will be conducted in close collaboration with industry partner, Mates in Construction.
COmBining Memantine And Cholinesterase Inhibitors In Lewy Body Dementia Treatment Trial (COBALT)
Funder
National Health and Medical Research Council
Funding Amount
$1,218,120.00
Summary
Many people who have been diagnosed with dementia with Lewy bodies or Parkinson’s disease dementia will be prescribed drugs known as acetylcholinesterase inhibitors (e.g. donepezil, rivastigmine, galantamine) to help with their symptoms. This research trial, known as COBALT, is designed to find out whether there is any benefit from taking the drug memantine as well. Australian and UK researchers are collaborating on this trial which will recruit eligible participants from both countries.
Steroid-Reducing Options For ReLapsING PMR (STERLING-PMR): A Pragmatic, Randomised Trial To Compare The Clinical And Cost-effectiveness Of Adding Immunosuppression To Steroid-tapering Treatment For Patients With Relapsing PMR, Versus Steroid-tapering
Funder
National Health and Medical Research Council
Funding Amount
$823,722.00
Summary
Polymyalgia rheumatica (PMR) is a common inflammatory disease of older people, treated with prednisolone (steroid tablet). About 50% will relapse and often suffer from steroid side effects (eg diabetes, bone fracture). This study will determine whether an extra treatment can reduce prednisolone use in people with relapsing PMR; and improve quality of life. The study will include participants in UK and Australia and provide a unique opportunity for further research in this under-researched area.
The Meniscal Transplant Surgery Or Optimised Rehabilitation Full Randomised Trial (MeTeOR2)
Funder
National Health and Medical Research Council
Funding Amount
$1,025,882.00
Summary
It can be hard to decide what treatment to use for people with pain and disability who have had the meniscus cartilage removed from the knee. Some surgeons try to improve pain and function by replacing the lost meniscus with a transplant from a donor who has died. The alternatives include exercises, physiotherapy, and bracing. This study will help us understand if the results for people who have the transplant are better or worse than for exercise and physiotherapy.