A Novel Pathway For The Regulation Of Vascular Tone
Funder
National Health and Medical Research Council
Funding Amount
$596,550.00
Summary
The regulation of blood pressure is complex involving the nervous system, kidneys and local pathways that generate blood vessel relaxing and constricting factors. We recently discovered a novel local pathway that becomes induced during inflammation and generates a relaxing substance from the amino acid tryptophan. The present project will identify the active substance and characterize how it causes blood vessel relaxation and thus contributes to the regulation of blood pressure.