Development Of Site-specific Predictive Assay For Periodontal Disease Progression Using Mass Spectrometric &RT- PCR Anal
Funder
National Health and Medical Research Council
Funding Amount
$150,000.00
Summary
In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crev ....In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crevicular fluid. This could provide insight into the development of periodontal disease and lead to new preventive and treatment regimes.Read moreRead less
The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - t ....The Sakai scheme-Askey table correspondence, analogues of isomonodromy and determinantal point processes. The Australian mathematical sciences enjoys two research groups with active interests on Painleve equations in applied mathematics which are able to address difficult problems. Such a problem is to give a formulation of Sakai's 2001 classification of the Painleve equations in a form most suitable for applications. For this links will be made with a seemingly distinct area of mathematics - the Askey table from the theory of hypergeometric orthogonal polynomials. A number of tractable PhD projects are suggested by this proposal.Read moreRead less
A new class of statistical methods for analysing long memory time series models with heteroskedasticity. This project will result in a class of statistical methods that will aid policy makers and financial analysts when examining and predicting key international and Australian macroeconomic and financial variables that exhibit long memory. Leading applications of long memory modelling in the literature include GDP, CPI, asset pricing models, stock returns, exchange rates and interest rates. It w ....A new class of statistical methods for analysing long memory time series models with heteroskedasticity. This project will result in a class of statistical methods that will aid policy makers and financial analysts when examining and predicting key international and Australian macroeconomic and financial variables that exhibit long memory. Leading applications of long memory modelling in the literature include GDP, CPI, asset pricing models, stock returns, exchange rates and interest rates. It will be possible to robustly and efficiently analyse such series in the presence of changes in variability, such as the overall reduction in variability that has occurred since the 1970's, called the "Great Moderation". The utility of the new methods will be demonstrated by a robust and efficient analysis of the Purchasing Power Parity hypothesis.Read moreRead less
Helping Central Banks Measure Unobserved Variables Using Real-time Forecasts. The project addresses structural measurement problems confronted routinely by central bankers. The techniques developed, and the estimates provided, will aid directly the Partner Organisations (the Reserve Bank of Australia, the Reserve Bank of New Zealand and Norges Bank) and other central banks in formulating monetary policy. The analysis will allow interest rates in Australia and elsewhere to be set with greater pre ....Helping Central Banks Measure Unobserved Variables Using Real-time Forecasts. The project addresses structural measurement problems confronted routinely by central bankers. The techniques developed, and the estimates provided, will aid directly the Partner Organisations (the Reserve Bank of Australia, the Reserve Bank of New Zealand and Norges Bank) and other central banks in formulating monetary policy. The analysis will allow interest rates in Australia and elsewhere to be set with greater precision. The techniques developed in this project will facilitate the understanding and communication of monetary policy within the central banks concerned, and enhance communication of monetary policy strategy to the public.Read moreRead less
Australian Real Time Data: Construction, Analysis and Implications for Real Time Policy Making. This first comprehensive macroeconomic real time database for Australia recording the actual data available to policy makers at the time of making decisions will serve as a standard reference for accurate ex post macroeconomic policy evaluation and for accurate forecasts and decision making which are robust to data revisions. The free database will be of interest to Australian researchers, economists, ....Australian Real Time Data: Construction, Analysis and Implications for Real Time Policy Making. This first comprehensive macroeconomic real time database for Australia recording the actual data available to policy makers at the time of making decisions will serve as a standard reference for accurate ex post macroeconomic policy evaluation and for accurate forecasts and decision making which are robust to data revisions. The free database will be of interest to Australian researchers, economists, forecasters and policy makers. Readily applicable and interpretable forecasts of the business cycle and the current state of the Australian (and US) economy (e.g. likelihood of recessions or inflation) will be of direct relevance to Australian policy-makers in Government, the Reserve Bank of Australia, and to the Australian decision-makers. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101201
Funder
Australian Research Council
Funding Amount
$366,404.00
Summary
Planar Brownian motion and complex analysis. This project will study a number of related problems concerning both Brownian motion and complex analysis. These include questions about Brownian exit time, conformally invariant processes such as Stochastic Loewner Evolution, and the fundamentals of complex analysis. Many of these questions are at the forefront of modern probability theory. The outcomes of this project will bring the questions considered into a position of prominence in the fields of ....Planar Brownian motion and complex analysis. This project will study a number of related problems concerning both Brownian motion and complex analysis. These include questions about Brownian exit time, conformally invariant processes such as Stochastic Loewner Evolution, and the fundamentals of complex analysis. Many of these questions are at the forefront of modern probability theory. The outcomes of this project will bring the questions considered into a position of prominence in the fields of probability and analysis, and bring international attention to Australia as a hub of important research.Read moreRead less
New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This ....New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This will provide significant benefits to all fields in which data displays any form of trending behaviour. The proposed model is used to evaluate the economic consequences of climate change and global housing market contagion, which provide strong evidence-based insights to the environmental and economic policies in Australia.Read moreRead less
Real groups, Hodge theory, and the Langlands program. This mathematics project aims to settle open questions in real groups. The real groups are the fundamental symmetries occurring in nature and are important both in number theory and in the physical sciences. In particular, this project aims to reach a comprehensive understanding of Langlands duality for real groups, investigate how Hodge theory can be used to describe the unitary dual, and investigate the micro-local structure of systems of d ....Real groups, Hodge theory, and the Langlands program. This mathematics project aims to settle open questions in real groups. The real groups are the fundamental symmetries occurring in nature and are important both in number theory and in the physical sciences. In particular, this project aims to reach a comprehensive understanding of Langlands duality for real groups, investigate how Hodge theory can be used to describe the unitary dual, and investigate the micro-local structure of systems of differential equations. Potential benefits include increasing the international stature of mathematics in Australia and improving the quality of the workforce.Read moreRead less
Symmetries in real and complex geometry. This project concerns an important area of abstract modern geometry. The results and techniques of the project will lead to significant progress in this area. It will benefit the national scientific reputation, strengthen the research profile of the home institutions, and provide training to young researchers.
A Multivariate Dynamic Factor Model of the Australian Business Cycle: Specification, Estimation and Empirical Results. The project aims to extend greatly existing models of national and international business cycles by developing a general class of dynamic factor models for Australia. The project provides a significant contribution to business cycle modelling by solving the intractability problems common to existing classes of dynamic factor models. A key innovation is the development of a simul ....A Multivariate Dynamic Factor Model of the Australian Business Cycle: Specification, Estimation and Empirical Results. The project aims to extend greatly existing models of national and international business cycles by developing a general class of dynamic factor models for Australia. The project provides a significant contribution to business cycle modelling by solving the intractability problems common to existing classes of dynamic factor models. A key innovation is the development of a simulation based estimator to circumvent the statistical and computational problems associated with existing estimators. The expected outcome of the project will be a more reliable way to monitor the phases of the cycle and forecast turning points, which will be of substantial national benefit.Read moreRead less