Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Novel audio watermarking techniques for tracing multimedia piracy. This project aims to develop inaudible, high-capacity audio watermarking techniques to trace the illegal copying and distribution of multimedia data containing a sound component, such as audios and sound videos. With the rapid growth of communication networks and the use of advanced multimedia technology, digital multimedia data can be easily copied, manipulated and distributed. This has led to strong demand for new techniques to ....Novel audio watermarking techniques for tracing multimedia piracy. This project aims to develop inaudible, high-capacity audio watermarking techniques to trace the illegal copying and distribution of multimedia data containing a sound component, such as audios and sound videos. With the rapid growth of communication networks and the use of advanced multimedia technology, digital multimedia data can be easily copied, manipulated and distributed. This has led to strong demand for new techniques to prevent illegal use of copyrighted data. The project is expected to advance the theory of audio watermarking and enhance Australia's international competitiveness in this field.
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A provable privacy-preserving data sharing system for the cloud environment. This project aims to develop an innovative data sharing system, with a mathematically provable privacy guarantee, in a cloud environment. This will be adopted by Australian Education Management Group’s (AEMG) cloud campus to exchange data in a restricted privacy manner between partner institutions. It will be commercialised as a middleware that can be plugged into existing cloud environments to maintain required privacy ....A provable privacy-preserving data sharing system for the cloud environment. This project aims to develop an innovative data sharing system, with a mathematically provable privacy guarantee, in a cloud environment. This will be adopted by Australian Education Management Group’s (AEMG) cloud campus to exchange data in a restricted privacy manner between partner institutions. It will be commercialised as a middleware that can be plugged into existing cloud environments to maintain required privacy even when the cloud crosses various jurisdictions with different privacy policies. The outcomes will benefit educational organisations, and lay the foundations for data sharing in other communities such as the government, banks, and other industries in Australia.Read moreRead less
Privacy-Preserving Fog Info System in Infrastructure-Deficient Environments. Due to Australia’s unique geographical distribution and population density, many regional or remote areas lack infrastructural support and development, including telecommunications and electricity supply. It is important to provide information and communication services in such infrastructure-deficient environments. In this project, we will develop a first-ever commercially ready Fog information system, or FogIS in shor ....Privacy-Preserving Fog Info System in Infrastructure-Deficient Environments. Due to Australia’s unique geographical distribution and population density, many regional or remote areas lack infrastructural support and development, including telecommunications and electricity supply. It is important to provide information and communication services in such infrastructure-deficient environments. In this project, we will develop a first-ever commercially ready Fog information system, or FogIS in short, to enable localised information and communication services, while preserving users' privacy, in infrastructure-deficient environments. The deployment of this system will bring great benefits to Australia’s economic growth, the quality of life, cybersecurity, and environment control in rural and regional Australia. Read moreRead less
Developing an active defence system to identify malicious domains and websites. This project aims to develop an innovative active defence system to effectively identify malicious Internet domains and websites. It can secure the cyberspace that is essential to the daily work of Australian people, thus addresses a fundamental problem in safeguarding Australia from cyber crime and terrorism.
New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerat ....New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerative diseases such as Alzheimer's disease. Read moreRead less
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the ....Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the bladder. Project research into the design of the electrode will focus on providing safe, effective and efficient stimulation of the neosphincter, while ensuring minimal damage to the surrounding tissues and affording straightforward implantation at surgery.Read moreRead less
Development of an electrode assembly for the stimulation of a transplanted innervated smooth muscle sphincter. This project will design and assess a number of different electrode designs for use in a medical device being developed for the treatment of severe stress urinary incontinence. The project will identify an optimal electrode design, which will be used in future clinical trials of the device.
Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement . This project investigates the impact of obesity on alignment and knee load over time in those who have undergone total knee replacement. This information is critical for understanding whether obesity results in increasing knee load after surgery which can lead to more rapid wearing of the knee surfaces and an earlier need for revision surgery.