Discovery Early Career Researcher Award - Grant ID: DE130101760
Funder
Australian Research Council
Funding Amount
$374,000.00
Summary
Uncovering the roles of key ribonucleases critical for post-transcriptional control of chloroplast gene expression. Higher plant chloroplasts harbour key biological processes that are essential to life on earth. Deciphering the roles of important plastid-targeted ribonucleases, central to post-transcriptional ribonucleic acid (RNA) processing events, is crucial to elucidate the genetic elements required to engineer chloroplast metabolic pathways to enhance productive crop yields.
Who’s who in the plant gene world? As many more plant genomes are sequenced, the bottleneck is being able to interrogate and translate this data into applications for crop improvement. This project will develop and apply a population graph database, hosting genome data for the world’s major crops and their wild relatives, allowing the characterisation of gene diversity on an unparalleled scale. Analysis of this data will reveal the presence/absence and sequence diversity for classes of genes for ....Who’s who in the plant gene world? As many more plant genomes are sequenced, the bottleneck is being able to interrogate and translate this data into applications for crop improvement. This project will develop and apply a population graph database, hosting genome data for the world’s major crops and their wild relatives, allowing the characterisation of gene diversity on an unparalleled scale. Analysis of this data will reveal the presence/absence and sequence diversity for classes of genes for important agronomic traits including disease resistance, flowering time and legume nitrogen fixation which will enable plant breeders to identify and apply novel genes and allelic variants for use in breeding programmes, accelerating the production of improved crop varieties.Read moreRead less
Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent ....Understanding disease resistance gene evolution across the Brassicaceae. Pan genomes represent the diversity of a species, including structural and sequence variation, which cannot be provided by a reference genome alone. In this project we will characterise resistance gene diversity across the Brassicaceae pan genomes. Through comparison with resistance gene diversity in cultivated Brassica species we will understand selection underlying resistance gene evolution in wild species and subsequent domestication and breeding. Knowledge on how variation affects disease susceptibility, especially to the devastating fungal pathogen blackleg, and contributes to phenotypic variation, will lead to improved plant protection strategies and increased crop resilience.Read moreRead less
The More the Merrier? Investigating copy number variation in Brassicas. This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including diseas ....The More the Merrier? Investigating copy number variation in Brassicas. This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including disease susceptibility, and the same seems to apply in plants. This project aims to apply the genome sequences for Brassica species to detect CNVs from re-sequencing data. Knowing how this variation affects an individual or line’s disease susceptibility, especially to the devastating fungal pathogen blackleg, could improve plant protection strategies and crop production.Read moreRead less
The developmental and evolutionary origins of vertebrate fins and limbs. This project aims to investigate the origin of paired appendages, a major event in early vertebrate history that changed ecological opportunity and fuelled the radiation of jawed vertebrates. This project expects to generate new knowledge on the mechanism that drove this innovation, which despite over a century of debate, remains one
of the great unknowns of comparative vertebrate evolution. Expected outcomes of this projec ....The developmental and evolutionary origins of vertebrate fins and limbs. This project aims to investigate the origin of paired appendages, a major event in early vertebrate history that changed ecological opportunity and fuelled the radiation of jawed vertebrates. This project expects to generate new knowledge on the mechanism that drove this innovation, which despite over a century of debate, remains one
of the great unknowns of comparative vertebrate evolution. Expected outcomes of this project include uncovering the anatomical changes underpinning the origin of the vertebrate appendicular system. This should provide significant benefits as it will inform our own natural history and provide a paradigm for studying gene network
conservation, phylogenetic modifications, and the acquisition of novel structures.Read moreRead less
Regulatory design for water quality management in urban catchments. This project aims, through empirical research (i) to evaluate the effectiveness of current regulatory, quasi-regulatory and other policy strategies for water quality management in urban catchments (including total/integrated catchment management); (ii) to provide practical policy prescriptions concerning how through judicious regulatory and institutional design, those problems may be best addressed for the future; and (iii) adva ....Regulatory design for water quality management in urban catchments. This project aims, through empirical research (i) to evaluate the effectiveness of current regulatory, quasi-regulatory and other policy strategies for water quality management in urban catchments (including total/integrated catchment management); (ii) to provide practical policy prescriptions concerning how through judicious regulatory and institutional design, those problems may be best addressed for the future; and (iii) advance regulatory theory by developing a framework for understanding the relative effectiveness of different regulatory regimes in the context of urban catchment management. Its empirical focus is on the Swan-Canning river in Western Australia.Read moreRead less
Characterising structural variation in the canola genome. Characterising structural variation in the canola genome. This project aims to develop and apply genomic tools to identify and characterise structural genome variation in canola, a major Australian export crop, to better understand genome evolution and accelerate canola breeding. Advances in DNA sequencing revolutionise our understanding of crop genomes, their evolution and impact on the inheritance on agronomic traits. Variation of genom ....Characterising structural variation in the canola genome. Characterising structural variation in the canola genome. This project aims to develop and apply genomic tools to identify and characterise structural genome variation in canola, a major Australian export crop, to better understand genome evolution and accelerate canola breeding. Advances in DNA sequencing revolutionise our understanding of crop genomes, their evolution and impact on the inheritance on agronomic traits. Variation of genome structure between individuals could be important in the inheritance of important agronomic traits. Recent advances in technology permit the detailed characterisation of structural variation on a previously unfeasible scale. Anticipated outcomes are enhanced global food security, supporting rural Australian economies, and accelerating the improvement of other major crops.Read moreRead less
Designing Better Landowner Contracts to Protect Australia's Environment. There will be two main benefits from this project. First a reduction in the cost of protecting the environment and second, a greater awareness amongst regulators of the determinants of compliance costs and their variability amongst landowners. By making environmental contracts more efficient, this project will contribute towards making Australian agriculture more sustainable in terms of protecting biodiversity, conserving ....Designing Better Landowner Contracts to Protect Australia's Environment. There will be two main benefits from this project. First a reduction in the cost of protecting the environment and second, a greater awareness amongst regulators of the determinants of compliance costs and their variability amongst landowners. By making environmental contracts more efficient, this project will contribute towards making Australian agriculture more sustainable in terms of protecting biodiversity, conserving water and reducing the rate of soil loss.Read moreRead less
Complexities of the mitochondrial transcriptome. This project aims to understand mitochondrial gene expression and energy production. Energy production is important for living things to grow and develop. In mammals, the mitochondria, the energy producing “powerhouses of the cell”, contain their own genetic assembly instructions. This project aims to understand these genetic instructions, revealing how genes control energy production. This project will characterise the genetic instructions, the m ....Complexities of the mitochondrial transcriptome. This project aims to understand mitochondrial gene expression and energy production. Energy production is important for living things to grow and develop. In mammals, the mitochondria, the energy producing “powerhouses of the cell”, contain their own genetic assembly instructions. This project aims to understand these genetic instructions, revealing how genes control energy production. This project will characterise the genetic instructions, the mitochondrial transcriptome and the proteins that control them. These advances are expected to provide a mechanistic understanding of how gene expression responds to changes in cellular energy demands. This knowledge will generate new biotechnological tools for Australian science and will have important long-term implications for improving agriculture and medicineRead moreRead less
Integrating economics and science for land, water and biodiversity policy. Australian government programs for land and water conservation involve expenditure of billions of dollars, combined with much larger contributions from program participants. However, various problems with these programs have been identified. This research will assist program investors to better target funding, to employ more appropriate policy mechanisms, and to operate in a cost-effective way, achieving the most highly v ....Integrating economics and science for land, water and biodiversity policy. Australian government programs for land and water conservation involve expenditure of billions of dollars, combined with much larger contributions from program participants. However, various problems with these programs have been identified. This research will assist program investors to better target funding, to employ more appropriate policy mechanisms, and to operate in a cost-effective way, achieving the most highly valued environmental outcomes that can be achieved with the available budget. The project will develop improved theories, frameworks and economic models, integrating information from physical, biological and social sciences, and decision tools for use by environmental decision makers.Read moreRead less