A New Model For The Pathogenesis Of Rheumatic Fever: Superantigen Priming Of The Immune Response To Group A Streptococci
Funder
National Health and Medical Research Council
Funding Amount
$248,820.00
Summary
Acute rheumatic fever (ARF) is now rare in developed countries. However, it remains a major problem in Aboriginal Australians in the NT where the rate of ARF is the highest in the world. This leads to high rates of rheumatic heart disease (up to 3% of individuals in some communities) and a premature mortality of over four times that for developing countries. Immunisation and improved living conditions offer a long-term solution but these remain a distant prospect. In the short and medium term, c ....Acute rheumatic fever (ARF) is now rare in developed countries. However, it remains a major problem in Aboriginal Australians in the NT where the rate of ARF is the highest in the world. This leads to high rates of rheumatic heart disease (up to 3% of individuals in some communities) and a premature mortality of over four times that for developing countries. Immunisation and improved living conditions offer a long-term solution but these remain a distant prospect. In the short and medium term, control of this ARF will partly depend on new and better treatment and prevention strategies. To achieve these goals a deeper understanding of the immune mechanisms underlying this disease is urgently needed. It is known that ARF is caused by an abnormal immune response following streptococcal infection. This leads to the production of cells called T cells that attack the body s own tissues rather than the bacteria itself. This autoimmune disease is responsible for the heart damage that underlies ARF. It is believed that this proces only occurs when susceptible individuals are infected with specific rheumatogenic strains of streptococci. However there are a number of deficiencies in this model and it is proposed that there is an additional factor responsible for the abnormal immune response in ARF. This project will explore the possibility that bacterial toxins called superantigens are the critical missing factor , by studying the immune response in ARF. Superantigens are produced by certain streptococci and staphylococci, and are potent in minute quantities causing widespread activation of the immune system. They have been found to play an important role in a number of autoimmune diseases and the type of immune response found in ARF fits well with that expected if superantigens were involved. If superantigens play an important role in causing the abnormal immune response in ARF then a number of new avenues would open for the treatment and prevention of this disease.Read moreRead less
Estimating The Burden Of Group A Streptococcal Diseases In Victoria
Funder
National Health and Medical Research Council
Funding Amount
$386,760.00
Summary
Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal pop ....Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal population (e.g. rheumatic fever, kidney disease). Streptococcal sore throat remains one of the most common childhood infections, and severe group A streptococcal diseases are thought to be increasing in incidence in Australia. Yet, there are no accurate data on the incidence and costs of these or other GAS diseases in non-Aboriginal Australians, or in most other populations around the world. It is becoming more urgent to collect this data as numerous vaccine candidates are entering human trials, new approaches to the treatment of sore throat are emerging, and new strategies to treat and control the spread of severe disease are being developed. We propose a comprehensive strategy to measure the incidence, prevalence and costs of each group of GAS diseases. We will follow a group of families for 12 months to detect cases of GAS sore throat and skin sores and measure the impact on the family. We will survey children in schools to estimate the prevalence of skin sores. We will check hospital records to calculate the number of cases of rheumatic fever and kidney disease. And we will maintain surveillance for severe diseases by checking hospital and laboratory records. We will also check to see if family members of people with severe disease have the GAS bacterium in their throats. We will then compile these data into a comprehensive estimate of the burden of disease in Victoria, and estimate the cost-effectiveness of different treatment and prevention strategies.Read moreRead less
Reconnecting Warlpiri communities with cultural heritage materials. The projects aims to reconnect Warlpiri communities with past documentation and recordings of their cultural heritage. Centred in Yuendumu, the project expects to unpack the significance of past documentation of cultural heritage for present day Warlpiri people who live in vastly different social worlds from their forebears. Through collaborations with Warlpiri families, and Partner Organisation, Pintupi Anmatyerr Warlpiri (PAW) ....Reconnecting Warlpiri communities with cultural heritage materials. The projects aims to reconnect Warlpiri communities with past documentation and recordings of their cultural heritage. Centred in Yuendumu, the project expects to unpack the significance of past documentation of cultural heritage for present day Warlpiri people who live in vastly different social worlds from their forebears. Through collaborations with Warlpiri families, and Partner Organisation, Pintupi Anmatyerr Warlpiri (PAW) Media and Communications, the project will see the set up of activities to engage with these materials and the production of resources for use by future generations.Read moreRead less
Co-designing a resilient water-energy toolbox with Indigenous communities. The aim is to collaboratively create a toolbox of innovative, community-based approaches for water and energy management in remote Australia. This project will combine digital and cultural approaches to create a novel set of tested and evaluated tools for engaging both community and service providers in transforming water and energy use practises in remote Indigenous communities. The key output will be an empirically-test ....Co-designing a resilient water-energy toolbox with Indigenous communities. The aim is to collaboratively create a toolbox of innovative, community-based approaches for water and energy management in remote Australia. This project will combine digital and cultural approaches to create a novel set of tested and evaluated tools for engaging both community and service providers in transforming water and energy use practises in remote Indigenous communities. The key output will be an empirically-tested and user friendly water-energy toolbox tailored to reduce the currently extreme cost of supplying essential services to remote communities. Application of these outputs will significantly reduce demand on local water sources and diesel-generated energy use while creating a skill base for local employment opportunities.Read moreRead less
Can coastal floodplains of north Australia survive ferals and rising seas? Tropical Coastal Floodplains are an iconic feature of northern Australia; however, they are experiencing widespread degradation due to complex interactions between feral ungulates and relative sea level rise. Using cross-cultural multidisciplinary methods, this project will discover if feral ungulate control by the Aboriginal Yirralka Rangers will reduce vegetation decline and erosion and enhance floodplain resilience to ....Can coastal floodplains of north Australia survive ferals and rising seas? Tropical Coastal Floodplains are an iconic feature of northern Australia; however, they are experiencing widespread degradation due to complex interactions between feral ungulates and relative sea level rise. Using cross-cultural multidisciplinary methods, this project will discover if feral ungulate control by the Aboriginal Yirralka Rangers will reduce vegetation decline and erosion and enhance floodplain resilience to sea level rise. This project will provide significant new data to inform feral ungulate management strategies as well as coastal carbon models as these processes are likely to create a carbon source rather than sink. Our collaborative science will have local to national benefits for natural and cultural resource management.Read moreRead less
ARC Centre of Excellence for Indigenous Futures. ARC Centre of Excellence for Indigenous Futures. The ARC Centre of Excellence for Indigenous Futures aims to transform and improve the life chances of Indigenous Australians by utilising Indigenous knowledges in unique trans-disciplinary cross-sector designed research to enhance our understanding about the complex nature of Indigenous intergenerational inequity. The Centre expects to generate new knowledge to enable evidence-based policy formulati ....ARC Centre of Excellence for Indigenous Futures. ARC Centre of Excellence for Indigenous Futures. The ARC Centre of Excellence for Indigenous Futures aims to transform and improve the life chances of Indigenous Australians by utilising Indigenous knowledges in unique trans-disciplinary cross-sector designed research to enhance our understanding about the complex nature of Indigenous intergenerational inequity. The Centre expects to generate new knowledge to enable evidence-based policy formulation and implementation including best practice models. The Centre will be entirely led by Indigenous researchers working with communities, government agencies and practitioners to strengthen the delivery of outcomes and linkages intentionally focused on all four of the National Agreement Close The Gap -2020’s Priority Reform areas.Read moreRead less
Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project ....Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project will provide new tools and technologies that will monitor mobile small vertebrates. Expected outcomes will improve the understanding of tropical savanna functioning and fire management. The research aligns with ‘savanna burning’ methodologies and carbon sequestration goals in north Australia.
Read moreRead less
Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will b ....Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will be combined with isotopic analysis to reveal how environmental and biological factors drive animal movements and impact habitat connectivity. In a world of vanishing top predators, it is imperative to understand system dynamics before we can evaluate the impact of species removal on ecosystem function.Read moreRead less
Achieving true representation of Indigenous people in nursing and midwifery. This project aims to address an absence of true representation of Aboriginal and Torres Strait Islander peoples and knowledges in nursing and midwifery. Significantly it intends to co-create an Aboriginal and Torres Strait Islander nurse and midwife theory and principles for practice. An anticipated goal of the research is to better understand how the theory and practice can be implemented in nurse and midwifery educati ....Achieving true representation of Indigenous people in nursing and midwifery. This project aims to address an absence of true representation of Aboriginal and Torres Strait Islander peoples and knowledges in nursing and midwifery. Significantly it intends to co-create an Aboriginal and Torres Strait Islander nurse and midwife theory and principles for practice. An anticipated goal of the research is to better understand how the theory and practice can be implemented in nurse and midwifery education (inclusive of clinical settings) in regional and urban areas. The intended outcome is to provide improved cultural safety in nursing and midwifery, greater cultural safety for health consumers and; stronger recruitment and retention of Indigenous nurses and midwives.
Read moreRead less
Re-integrating Central Australian community cultural collections. This project aims to apply current research on archiving and community access to find practical solutions to managing the large amounts of recorded cultural material of interest to the Central Land Council, the peak Indigenous representative body covering the southern half of the Northern Territory. The project aims to identify and integrate information in a common database, work with community members to create a prioritised list ....Re-integrating Central Australian community cultural collections. This project aims to apply current research on archiving and community access to find practical solutions to managing the large amounts of recorded cultural material of interest to the Central Land Council, the peak Indigenous representative body covering the southern half of the Northern Territory. The project aims to identify and integrate information in a common database, work with community members to create a prioritised list of any at-risk materials and apply locally meaningful categories for managing the archival materials relevant to their community, and deliver appropriate documentation of process, permissions and reports to support ongoing sustainability of the collections.Read moreRead less