Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay ....Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay for environmental services in northern Australia but also of the perceptions of the indigenous people who are providing these services. Choice modelling can (1) quantify values of different environmental services in different sectors of society and (2) help allocate the payments for environmental services efficiently.Read moreRead less
Analysis of legislation and policies affecting the development of Indigenous wildlife-based enterprises. Entrepreneurial enterprise development by Indigenous people in remote regions is being encouraged as part of government policy to move people off welfare and into work. Indigenous knowledge of wildlife makes it a logical source of wealth generation but a range of legal and policy constraints add to substantial existing social and logistical problems. An understanding of the legal processes in ....Analysis of legislation and policies affecting the development of Indigenous wildlife-based enterprises. Entrepreneurial enterprise development by Indigenous people in remote regions is being encouraged as part of government policy to move people off welfare and into work. Indigenous knowledge of wildlife makes it a logical source of wealth generation but a range of legal and policy constraints add to substantial existing social and logistical problems. An understanding of the legal processes involved in establishing and maintaining sustainable and ongoing wildlife-based enterprises will improve their chances of success, and will also offer the opportunity to change regulatory frameworks to ensure consistency, remove contradictions and encourage workforce participation. The research will have national and international implications.Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
Special Research Initiatives - Grant ID: SR200200605
Funder
Australian Research Council
Funding Amount
$247,683.00
Summary
Australian Boys: Beyond the Boy Problem. In Australia, most research on boys and boyhood is focused on risk-reduction, representing boys as problems at school, on the streets, or in relationships, with an ambivalent (if not oppositional) relation to feminism. At the same time, anti-feminist public discourse highlighting the experiences of boys and young men is used to justify violence towards women as well as call for the reversal of social changes that have expanded opportunities available to g ....Australian Boys: Beyond the Boy Problem. In Australia, most research on boys and boyhood is focused on risk-reduction, representing boys as problems at school, on the streets, or in relationships, with an ambivalent (if not oppositional) relation to feminism. At the same time, anti-feminist public discourse highlighting the experiences of boys and young men is used to justify violence towards women as well as call for the reversal of social changes that have expanded opportunities available to girls. This research project will develop a framework for interdisciplinary research that takes Australian boys and boyhood as the subjects of a more inclusive future, working to overcome ingrained oppositions between feminist scholarship and the lives and interests of boys. Read moreRead less
Improved Indigenous population projections for policy and planning. This project will use a range of methods to understand the population dynamics of the Australian Aboriginal and Torres Strait Islander (Indigenous) population. This information will allow policy makers to plan and target resources and help Indigenous organisations understand what is happening to the population in their communities.
Developing Robust Small Area Population Forecasts for Planning and Policy. This project aims to create more robust, detailed, and accurate small area population forecasts, and implement them in a sophisticated forecasting system for one jurisdiction in Australia, USA, UK and Canada. The project is significant as it expects to generate a suite of new and innovative methods, theory, and population forecasts that will be useful to researchers and planners both in Australia and overseas. Expected ou ....Developing Robust Small Area Population Forecasts for Planning and Policy. This project aims to create more robust, detailed, and accurate small area population forecasts, and implement them in a sophisticated forecasting system for one jurisdiction in Australia, USA, UK and Canada. The project is significant as it expects to generate a suite of new and innovative methods, theory, and population forecasts that will be useful to researchers and planners both in Australia and overseas. Expected outcomes include new forecasting methods, associated computer code, many open-access academic papers, and new international collaborations. More detailed and reliable population forecasts will bring substantial benefits to those planning our future infrastructure requirements (e.g. schools, hospitals, housing and transport).
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The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less