Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
Deciphering The Transcriptional Program That Instructs Lymphatic Endothelial Cell Fate.
Funder
National Health and Medical Research Council
Funding Amount
$541,950.00
Summary
Lymphatic vessels are essential to maintain fluid balance in most tissues of the human body. Further the lymphatic vasculature plays a central role during cancer and contributes to tumour metastasis. Despite this integral function in health and disease little is known about the molecular programs that coordinate gene expression to build a functional vasculature. This research project will address this gap in our knowledge and will open up new therapeutic avenues for lymphatic vascular disorders
Identifying cost-effective reforestation approaches for biodiversity conservation and carbon sequestration in the Australian wet tropics. There is great potential for rainforest reforestation to help in the protection of Australia's tropical flora and fauna. Little is known, however, about how to reforest pasture to rainforest for the purpose of maximising the recovery of native biodiversity. We propose a unique experimental study of rainforest reforestation practices with biodiversity conservat ....Identifying cost-effective reforestation approaches for biodiversity conservation and carbon sequestration in the Australian wet tropics. There is great potential for rainforest reforestation to help in the protection of Australia's tropical flora and fauna. Little is known, however, about how to reforest pasture to rainforest for the purpose of maximising the recovery of native biodiversity. We propose a unique experimental study of rainforest reforestation practices with biodiversity conservation as a primary goal. Reforestation is currently an unlikely option for most landholders in Australia's tropics given the lack of data on the economic benefits obtainable from such efforts. Our study examines the profits obtainable through the carbon market for each reforestation approach with the goal of increasing the feasibility of rainforest reforestation in North Queensland.Read moreRead less
Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understandin ....Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.Read moreRead less
Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high reso ....Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high resolution time-series information on soil moisture and vegetation status from space represents a powerful tool for understanding climate change impacts on Australia. It is therefore imperative that products be developed specifically for the Australian environment to take full advantage of radar data from satellites.Read moreRead less
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Reducing the deleterious impacts of clay particle interactions with valuable minerals in copper and gold processing. This project seeks to understand the rheological behaviour of clay minerals and the effect of the viscosity caused by clay minerals on gas dispersion, the transport of network structures and the locking of the structures in the froth in mineral flotation. Novel methods will be developed to improve flotation separation by reducing the viscosity.
Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even cont ....Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even contemplated today.
In addition to the scientific benefits, there are also immediate commercial applications in Australia and worldwide for ophthalmic products (e.g. anti-fog and easy to clean lenses), if the balance of properties can be obtained.
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Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understandin ....Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understanding of how microbes control seagrass health and an enhanced capacity to develop effective restoration strategies for Australia's valuable seagrass ecosystems. Benefits include improving the extensive environmental, economic, social/cultural services Australian communities derive from seagrass ecosystems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100220
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, ....A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, the response of different ores to high voltage pulses will be studied to identify processes that liberate a greater percentage of valuable minerals while using less energy and less water and keeping toxic elements bound in larger waste particles. SelFrag-based research will therefore deliver major economic and environmental benefits to Australia.Read moreRead less