An Examination Of Motor Functioning In Autism And Asperger's Disorder: An Analysis Of Gait & Cortical Brain Activity.
Funder
National Health and Medical Research Council
Funding Amount
$120,220.00
Summary
Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poo ....Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poor coordination in posture and gesture. It has been suggested that there is disruption within the basal-ganglia-thalamocortical circuitry (the region connecting the frontal and sub-cortical structures), which may cause the motor dysfunction seen in autism and Asperger's disorder. Few studies have attempted to isolate particular stages of motor functioning which may account for the coordination and motor delay observed clinically in autism and Asperger's disorder. A recent study of ours found evidence to suggest that motor planning deficiencies may account for the 'clumsy' movement patterns frequently reported in the autism - Asperger's disorder literature. Therefore, the aim of this research is to provide a comprehensive neurobehavioural and neurophysiological analysis of motor functioning in young people with autism and Asperger's disorder to further examine the exact stages of motor processing which are deficient in these disorder groups. Recent retrospective studies have shown that even as infants children with autism exhibit clear features of motor disturbance, which, if detected and clearly defined, could advance early diagnosis. In addition to advancing the clinical definition of autism and Asperger's disorder, a careful examination of motor disturbance may also illuminate the neurobiological underpinnings of these disorders.Read moreRead less
Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster re ....Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster reef restoration that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of estuaries, and reestablish the environmental, economic and social benefits of oyster reefs.Read moreRead less
Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining ....Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining rehabilitation sites. Expected outcomes include clear industry guidelines that refine seed sourcing strategies for ecological restoration for current and future climates. This should provide significant benefits for improved ecological restoration outcomes when using native seed today and into the future.Read moreRead less
Testing the importance of large-scale climate factors to plant community assembly following land-use change. This project will examine the native plant species and functional diversity of Australia's rain forest communities to create a predictive framework of how plant communities recover following deforestation. Such a framework is key to focusing conservation efforts in degraded and multi-use landscapes.
Benefits Of Home-based Multidisciplinary Rehabilitation In Non Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$581,039.00
Summary
Lung cancer is the third leading cause of death in Australia. People with lung cancer experience a complex mix of symptoms that can provoke significant distress and impair physical function. This study aims to develop and test a home based exercise and self-management support program to increase function and physical activity levels, reduce levels of depression and improve quality of life of people with lung cancer.
Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equiv ....Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equivalent anionic toxicity models be developed. This project will develop the first such model, which will provide new insights on ecotoxicological modelling for inorganic anionic toxicants. The project will transform ecotoxicological modelling approaches for metals and metalloids in terrestrial systems and directly improve our ability to assess risks associated with environmental contamination.Read moreRead less
Setting rehabilitation targets for regulated floodplain wetlands: linking system structure and function. Limited understanding of ecosystem processes in floodplain wetlands impedes adaptive management strategies for combating the decline in aquatic productivity and biodiversity. This project addresses three knowledge gaps critical for effective floodplain wetland management: 1) hierarchical spatial and temporal patterns of structural diversity; 2) correspondence between patterns of structural d ....Setting rehabilitation targets for regulated floodplain wetlands: linking system structure and function. Limited understanding of ecosystem processes in floodplain wetlands impedes adaptive management strategies for combating the decline in aquatic productivity and biodiversity. This project addresses three knowledge gaps critical for effective floodplain wetland management: 1) hierarchical spatial and temporal patterns of structural diversity; 2) correspondence between patterns of structural diversity, rates of system production, and food web structure, and 3) conceptual models of relationships between hydrologic regime and wetland structure and function. The project will improve understanding of the impacts of regulation on floodplain wetlands, contribute to adaptive management, and set rehabilitation targets for delivery of environmental flows for ecosystem sustainability.Read moreRead less
Do artificial structures enhance the spread of exotic marine invertebrates in NSW estuaries? This project will investigate whether artificial structures in estuaries enhance the spread of exotic marine invertebrates and will examine the impacts of exotic species on rocky reef species. The introduction of exotic species is a significant threat to native biodiversity, second only to habitat destruction. These two threats are coincident in urbanised estuaries. This project will also provide infor ....Do artificial structures enhance the spread of exotic marine invertebrates in NSW estuaries? This project will investigate whether artificial structures in estuaries enhance the spread of exotic marine invertebrates and will examine the impacts of exotic species on rocky reef species. The introduction of exotic species is a significant threat to native biodiversity, second only to habitat destruction. These two threats are coincident in urbanised estuaries. This project will also provide information about the possible roles of different types of boating activity in transporting exotic species. Research on the role of artificial structures in invasions has not been done anywhere in the world and is essential if we are to understand, manage and ameliorate the threats of exotic species.Read moreRead less
Bioinvasions: the interactive effects of propagule pressure and pollution. The successful establishment of species outside their native range is an increasingly frequent occurrence and can cause reductions in biodiversity and ecosystem disruption. Bioinvasions may also cause public health risks and damage to agriculture and fisheries. Nowhere is the accelerating pace of bioinvasions more dramatic than in ports and harbours. This project will determine the effects of pollution on invasion in a ma ....Bioinvasions: the interactive effects of propagule pressure and pollution. The successful establishment of species outside their native range is an increasingly frequent occurrence and can cause reductions in biodiversity and ecosystem disruption. Bioinvasions may also cause public health risks and damage to agriculture and fisheries. Nowhere is the accelerating pace of bioinvasions more dramatic than in ports and harbours. This project will determine the effects of pollution on invasion in a marine system. This project is in the national interest because it will identify mechanisms through which the invasion of exotic species are encouraged and assist in the identification and prioritisation of effective management strategies to prevent invasion.Read moreRead less
Do pollution events facilitate biotic invasion in marine systems? This project aims to determine whether pollution affects the biological resistance of assemblages to invasion. The discharge of toxicants into coastal waters is an increasingly important source of disturbance that has the potential to make marine assemblages more susceptible to biotic invasion. The project will determine if pollution events facilitate the colonisation, persistence and spread of non-native species and how initial a ....Do pollution events facilitate biotic invasion in marine systems? This project aims to determine whether pollution affects the biological resistance of assemblages to invasion. The discharge of toxicants into coastal waters is an increasingly important source of disturbance that has the potential to make marine assemblages more susceptible to biotic invasion. The project will determine if pollution events facilitate the colonisation, persistence and spread of non-native species and how initial assemblage diversity modifies this response. The generality of several important ecological hypotheses developed in plant communities are tested in marine systems for the first time and extended to include the role of toxic disturbances.Read moreRead less