Biostatistical Innovation And Capacity Building To Advance Child Health And Life-course Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Biostatistics is a critical component of health and medical research. The proposed program of novel biostatistical research into methods for analysing incomplete data, an extensive portfolio of collaborative research in infant development, and establishment of a national biostatistics network, will facilitate my ongoing leadership in this critical discipline as well as enhancing the international standing of biostatistics in Australia.
Improving Communication About Immunisation Through Social Sciences Research
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
Vaccination is one of the greatest public health acheivements of the last century. Yet new threats to vaccine programs arise as diseases become less visible. Waning public confidence in immunisation and specific vaccine scares continue to threaten programs globally. This research will help to improve our understanding of why people do and don't immunise and the role communication can play. It will develop and test novel interventions to address public concerns and assist health professionals in ....Vaccination is one of the greatest public health acheivements of the last century. Yet new threats to vaccine programs arise as diseases become less visible. Waning public confidence in immunisation and specific vaccine scares continue to threaten programs globally. This research will help to improve our understanding of why people do and don't immunise and the role communication can play. It will develop and test novel interventions to address public concerns and assist health professionals in the way they communicate vaccine risk and benefit.Read moreRead less
A New Paradigm To Prevent Intracranial Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Increasing brain pressure after stroke or other forms of brain injury can cause further injury and death. Body cooling by 4-5 0C (hypothermia) for 12-24 hours saves lives after some forms of brain injury, but may have major side effects. We found that 2 hour hypothermia has a long-lasting effect preventing pressure elevation. We will determine the best temperature and duration of hypothermia in a stroke model and use imaging to confirm findings in patients, with a view to later human trials.
My research team is focused on human parasites of major relevance to the Australian water industry and/or global public health. Our primary focus is the use of advanced technologies to improve understanding of these parasites and to utilize this information to underpin development of new drugs to treat them and novel diagnostic tests to improve their control.
Optimising Treatment As Prevention Strategies For Hepatitis C And HIV
Funder
National Health and Medical Research Council
Funding Amount
$471,809.00
Summary
New evidence shows how hepatitis C (HCV) and HIV transmission can be reduced dramatically through timely treatment initiation - treatment as prevention (TasP). TasP has re-focused attention on early HCV and HIV detection and treatment. Through observational studies, randomised control trials and the development of innovative surveillance systems, this fellowship will inform ways to maximise the potential of HCV and HIV prevention responses in Australia and internationally in this new TasP era.
Exploring And Exploiting Novel Therapeutic Avenues In Mesothelioma
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Mesothelioma is a fatal cancer of the lungs. It rapidly grows and invades surrounding tissues such as the ribcage, causing severe shortness of breath and pain. Chemotherapy has limited effect and although immunotherapy appears promising, most patients do not respond. I will investigate why mesothelioma is so invasive; how to improve the response to immunotherapy and how to best combine chemotherapy and immunotherapy. I aim to develop new treatments that will benefit patients with mesothelioma.
Development Of Statistical Methodologies And Application To Clinical Cancer Studies
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Integrating different layers of information coming from the recent ‘-omics’ technologies can help improving the treatment and the prevention of complex diseases. In particular, the identification of molecular markers of different types can be used for better diagnostics and prognosis in cancer and immune diseases. This project will develop innovative statistical solutions to handle and make sense of the vast amount of biological data that are routinely generated in the laboratories.
Multiple sclerosis is the most common cause of neurological disability among young adults. The patients’ individual response to therapy is highly variable. The research vision completed during this Fellowship will generate novel evidence enabling individually-tailored therapy of multiple sclerosis. Through the newly established Clinical Outomes Research Unit at the Royal Melbourne Hospital, the expertise from observational data in multiple sclerosis will be applied in other areas of neurology.
Investigating Treatments And Biomarkers Of Brain Concussion
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Concussions are a serious and common international health concern, and repeated concussions can have severe long-term consequences on the brain. This project will aim to provide insight into this poorly understood disease projects and ultimately improve the management of concussions in human patients.