General Practice Optimising Structured MOnitoring To Improve Clinical Outcomes In Type 2 Diabetes: GP-OSMOTIC T2D
Funder
National Health and Medical Research Council
Funding Amount
$864,980.00
Summary
We will study the use of a new technology, retrospective continuous glucose monitoring (r-CGM), to help achieve glucose targets for people with type 2 diabetes (T2D) in General Practice (GP). This is important because controlling glucose levels improves disease outcomes and because T2D is mostly managed in GP where the majority of people are out of glucose target levels and GPs and patients currently don’t have a simple effective method for monitoring blood glucose levels to guide treatment.
An Integrated General Practice And Pharmacy-based Intervention To Promote The Prescription And Use Of Appropriate Preventive Medications Among Individuals At High Cardiovascular Risk.
Funder
National Health and Medical Research Council
Funding Amount
$2,380,071.00
Summary
We will conduct a randomised controlled trial that combines three methods to reduce risk factors and improve outcomes for people with cardiovascular disease (CVD). The methods include administration of a polypill, a GP-focused point-of-care intervention, and a pharmacy-led intervention to improve commencement and persistence with taking medications. We expect that integrating these three approaches will lead to large reductions in CVD risk factor levels for participants.
Using Collaboration Networks To Measure Bias And Inefficiency In The Production And Translation Of Evidence About Cardiovascular Risk
Funder
National Health and Medical Research Council
Funding Amount
$219,806.00
Summary
Doctors rely on clinical trials comparing the safety and efficacy of cardiovascular treatments but are often unable to find or trust the information they seek because of problems in evidence translation. This project will examine the networks of collaboration amongst researchers and their research to identify the source of these problems. The research will be used to identify where to intervene in the process, in turn helping doctors to make safe and cost-effective decisions for their patients.
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
Stepping Up To Insulin: A Cluster Randomised Trial Of Team-based Transition To Insulin In Primary Care For Patients With Poorly Controlled Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$796,751.00
Summary
Helping people control their diabetes through the best possible medical care is important. Most people with diabetes eventually need insulin yet this is a step in treatment that is often resisted by patients and GPs. This study will help GPs and Practice Nurses work with patients who have reached this stage make the change to insulin treatment in a safe, effective, convenient and timely way. This will have enormous benefits through reduced diabetes complications and improved quality of life.
Implementation And Sustainability Of Non-surgical Intervention For Dental Caries In General Dental Practice
Funder
National Health and Medical Research Council
Funding Amount
$390,388.00
Summary
Dentists in NSW and the ACT used new protocols to stop the spread of tooth decay. Many decayed teeth were then remineralised without the use of injections or drilling and filling. The process by which the dentists reorganised their practices to implement the protocols and how they explained them to their patients and practice staff will now be investigated to discover how best to promote their use Australia-wide. The sustainability and cost-effectiveness of this type of care will be measured.
The SAVE Trial: Securing All IntraVenous Devices Effectively In Hospitals. A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$980,393.00
Summary
Going to hospital usually means having an IV drip in your hand or arm vein. Almost half of all IV drips fall out or fail because they are not well secured to the skin. This means patients miss out on treatment and have additional painful needlesticks to insert new devices. Serious infections can also occur. This study will find the best dressings to use on IV drips. Patients will have their drips glued in with medical superglue, or have one of two new dressings, compared with current usual care.
Peripherally InSerted CEntral Catheter Securement: The PISCES Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,101,717.00
Summary
Cancer treatment often requires a peripherally inserted central catheter (PICC) for chemotherapy, transfusions, medicines, fluids, nutrition and/or blood sampling. Current PICC dressing and securement products are not preventing the 30% of PICCs that develop infection, occlusion, thrombosis or dislodgement. New products are available that may reduce complications. This trial will test their effectiveness, costs, comfort and practicality, working closely with patients, nurses and doctors.
The Out-and-About Trial: Improving Quality Of Life By Increasing Outdoor Journeys After Stroke
Funder
National Health and Medical Research Council
Funding Amount
$586,009.00
Summary
Many stroke patients cannot walk well when they leave hospital nor use public transport. Escorted outdoor journeys with a rehabilitation therapist can improve outcomes and quality of life after stroke. Yet not many stroke patients do not receive this type of community rehabilitation. This project aims to evaluate an implementation program to change therapists' practice and increase outdoor journeys after stroke. Benefits include improved quality of life and well being for peope with stroke.
Sedation Practice In Intensive Care Evaluation (SPICE) Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$2,752,725.00
Summary
Almost every patient in intensive care needs sedating drugs for comfort and provision of life-saving treatment. However, sedation causes side effects including coma, delirium and agitation. There is no high-level evidence to help doctors decide which sedatives to choose and the best way to administer them. The SPICE trial will test a new approach called Early Goal-Directed Sedation based on an alternative sedative agent to see whether it delivers safer, targeted light sedation with less delirium ....Almost every patient in intensive care needs sedating drugs for comfort and provision of life-saving treatment. However, sedation causes side effects including coma, delirium and agitation. There is no high-level evidence to help doctors decide which sedatives to choose and the best way to administer them. The SPICE trial will test a new approach called Early Goal-Directed Sedation based on an alternative sedative agent to see whether it delivers safer, targeted light sedation with less delirium.Read moreRead less