Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is ....Understanding, prediction and control of polymorphism in pharmaceuticals. The proposed research will lead, through a better understanding of polymorphism, to more efficient production of pharmaceuticals and will enhance the establishment and protection of patents. The work will have flow-on in other areas such as the manufacture of pigments, dyes and explosives. The project uses methodology for the elucidation of local structure and function at the atomic to nanoscale level in which Australia is a world leader. The project will further enhance our standing in this field and will provide excellent research training opportunities in areas particularly pertinent to future exploitation of the Australian Synchrotron and the new Research Reactor OPAL, which open in 2007. Read moreRead less
Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Bioeconomic Modelling of Marine Reserves. Australian waters contain a huge range of biodiversity, but are under threat from human activities. To face this challenge and resolve the problems of depleted fisheries and habitat destruction, innovative approaches are required to integrate marine biology with fisheries economics. The research meets this immediate need by developing bioeconomic models of marine reserves to determine reserve location and size, and analyse interactions between reserves a ....Bioeconomic Modelling of Marine Reserves. Australian waters contain a huge range of biodiversity, but are under threat from human activities. To face this challenge and resolve the problems of depleted fisheries and habitat destruction, innovative approaches are required to integrate marine biology with fisheries economics. The research meets this immediate need by developing bioeconomic models of marine reserves to determine reserve location and size, and analyse interactions between reserves and harvested areas under environmental uncertainty. The models will be developed using the latest developments in economics, biology and numerical methods and will be used to conserve Australia's marine biodiversity and improve fisheries management.Read moreRead less
Adaptive economic management of Australia's urban water. This project responds to the so-called 'wicked problem' of ensuring an adequate supply of water to urban consumers at the lowest price even during long-term droughts. The project will generate, for the first time in the world, an integrated, dynamic, and adaptive supply and demand model to manage urban water optimally over time.
Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of ....Quantifying the El Niño-Indian Ocean Dipole system using high-resolution coral palaeoclimate archives. The ocean surrounding Indonesia is the warmest on Earth and a major source of energy for global atmospheric circulation. Understanding the role of the Warm Pool in future climate change is of key importance, but highly controversial because the potential extent of its variability is largely unknown. To address this issue, this project will provide the first major geochemical investigation of recently discovered ancient corals in Indonesia using state-of-the-art microanalytical techniques. Outcomes from these palaeoclimate records will advance our understanding of global climate change, rainfall variability related to the El Nino - Indian Ocean Dipole system, and Australian drought.Read moreRead less
Monsoon extremes, environmental shifts, and catastrophic volcanic eruptions: quantifying impacts on the early human history of southern Australasia. The coincidence of a long, diverse Australasian human history with Earth's greatest climate systems presents the Australian and Indonesian communities with unrivalled opportunities for scientific discovery. Our study will improve understanding of global climate change, environmental shifts, volcanic catastrophes, and their role in early human disper ....Monsoon extremes, environmental shifts, and catastrophic volcanic eruptions: quantifying impacts on the early human history of southern Australasia. The coincidence of a long, diverse Australasian human history with Earth's greatest climate systems presents the Australian and Indonesian communities with unrivalled opportunities for scientific discovery. Our study will improve understanding of global climate change, environmental shifts, volcanic catastrophes, and their role in early human dispersal, and extinction, in Australasia. The significance of the results will extend to the modern world, where human behaviour modifies, and is modified by, climate and environment. Integration of research strengths in Australia and Indonesia will contribute to an improved bilateral relationship in science, education, and training, and engage the public in the excitement of scientific discovery.Read moreRead less
Multi-proxy fingerprinting, absolute dating, and large-scale modelling of Quaternary climate-volcano-environment impacts in southern Australasia. The discovery of Homo floresiensis (the Hobbit) revealed the surprising diversity of early humans and opened new ways for Australians and Indonesians to make tremendous scientific advances. Deployment of world-best analytical capabilities to untapped speleothem resources in Indonesia will put us at the forefront in understanding global climate change, ....Multi-proxy fingerprinting, absolute dating, and large-scale modelling of Quaternary climate-volcano-environment impacts in southern Australasia. The discovery of Homo floresiensis (the Hobbit) revealed the surprising diversity of early humans and opened new ways for Australians and Indonesians to make tremendous scientific advances. Deployment of world-best analytical capabilities to untapped speleothem resources in Indonesia will put us at the forefront in understanding global climate change, volcanic catastrophes, and environmental impacts on deep-time cultures shared by our nations. Our findings will extend to the modern world, where humans modify climates and landscapes at unprecedented rates. Integration of Australian and Indonesian research strengths will showcase bilateral science, education, and training, and engage the public in the excitement of scientific discovery.Read moreRead less
Simultaneous localisation and image fusion for robotic explorations. Australia has played a leading role in the field of autonomous system research that s becoming increasingly prevalent in industrial applications such as environment monitoring, remote sensing, and battlefield intelligence. Unstructured and landmark-deficient operating conditions impose significant challenges in achieving accurate mapping and localisation. This research will develop a framework for image-based mapping and fusion ....Simultaneous localisation and image fusion for robotic explorations. Australia has played a leading role in the field of autonomous system research that s becoming increasingly prevalent in industrial applications such as environment monitoring, remote sensing, and battlefield intelligence. Unstructured and landmark-deficient operating conditions impose significant challenges in achieving accurate mapping and localisation. This research will develop a framework for image-based mapping and fusion, thus contributing to the key enabling technologies for autonomous systems. The outcomes of this project will contribute to the current international leadership of Australia in this fast-evolving technology.Read moreRead less
The Indian Ocean Dipole, Australasian drought, and the great-earthquake cycle: Long-term perspectives for improved prediction. The protracted drought across Australia and Boxing Day 2004 earthquake in Sumatra defied prediction, and are causing incalculable environmental, economic, and social harm. Knowledge of past climate extremes will enhance our ability to predict climate change, and alleviate adverse affects for Australasian nations who miss-out in the future redistribution of life-giving mo ....The Indian Ocean Dipole, Australasian drought, and the great-earthquake cycle: Long-term perspectives for improved prediction. The protracted drought across Australia and Boxing Day 2004 earthquake in Sumatra defied prediction, and are causing incalculable environmental, economic, and social harm. Knowledge of past climate extremes will enhance our ability to predict climate change, and alleviate adverse affects for Australasian nations who miss-out in the future redistribution of life-giving moisture. Insights into the great-earthquake cycle will help fulfil Australia's responsibility to predict tsunamis, for the benefit of nations fringing Australasian seismotectonic zones. Development of improved techniques in palaeoclimatology, palaeoclimate modelling, and palaeoseismology will provide new collaborations and opportunities for research, training, and education.Read moreRead less