A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. T ....Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. The project will provide robust tools to predict water quality impacts under a range of conditions and it will develop techniques for the economic valuation of market and non-market impacts. The project will demonstrate the integration of water quality and economic modelling and how it can influence policy and investment in conservation and remediation.Read moreRead less
Special Research Initiatives - Grant ID: SR0354516
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-e ....Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-ecological landscapes is fragmented across disciplines, including natural sciences, social sciences and humanities. The interdisciplinary network on property rights in resource management will draw together researchers, building new synergies, novel research agendas and solutions for end users including property owners, resource managers, policy makers, planners and valuers.Read moreRead less
Special Research Initiatives - Grant ID: SR0354575
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and me ....Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and metadata modelling between these traditionally separate research groups, with the outcome of improving research efficiency and lowering costs. EON-ITNET will form an alliance with the Caltech-based GeoFramework, which is advancing a novel object-oriented data analysis environment, binding community software for Earth visualisation and simulation to 4D data bases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354582
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australia-NZ Network for Vegetation Function and Futures. Plants shape our landscapes and drive ecosystem processes from local to global scale. Plant species vary widely in quantitative functional traits. Global datasets about functional variation are emerging, with Australian and NZ leadership. A network would be supported in both Australia and NZ and with strong links elsewhere. It would target seven ambitious but achievable research developments. Each of them demands intensive conversation be ....Australia-NZ Network for Vegetation Function and Futures. Plants shape our landscapes and drive ecosystem processes from local to global scale. Plant species vary widely in quantitative functional traits. Global datasets about functional variation are emerging, with Australian and NZ leadership. A network would be supported in both Australia and NZ and with strong links elsewhere. It would target seven ambitious but achievable research developments. Each of them demands intensive conversation between separate disciplines. Networking across all seven strands will create a broader linkage, spanning across palaeobiology, ecosystem function, vegetation structure, global change, ecophysiology, phylogeny, genomics, ecoinformatics and evolutionary theory.Read moreRead less
Enhanced 3-D seismic structure for Southwest Australia. The ancient cratonic lithosphere of Southwest Australia appears to have a distinct contrast in geophysical properties and complex geologic structure, while having some of the highest levels of earthquakes on the continent. The project aims to produce novel 3-D models of this region that combine new seismic data collected over two years with previously collected geophysical datasets from the partner investigators. A compilation of 3-D models ....Enhanced 3-D seismic structure for Southwest Australia. The ancient cratonic lithosphere of Southwest Australia appears to have a distinct contrast in geophysical properties and complex geologic structure, while having some of the highest levels of earthquakes on the continent. The project aims to produce novel 3-D models of this region that combine new seismic data collected over two years with previously collected geophysical datasets from the partner investigators. A compilation of 3-D models will subsequently be developed, to form an effective characterisation of the geologic structure of the craton and its margins. These models will provide enhanced assessment of seismic ground shaking from regional earthquakes and facilitate an improved understanding of mineral resource potential. Read moreRead less
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less
Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in ....Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in decision-making in the event of an oil spill. This project will assess the relative toxicities of a number of petroleum hydrocarbons on Australian seagrass species to provide necessary data for the development of effective management practice.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Natural resources and ecosystem services in productivity measurement. This project aims to understand sources of productivity growth through addressing theoretical and practical problems in the economics of natural resources and ecosystem services. It will study the valuation of non-renewable resources and ecosystem services, acknowledging their contributions to economic activity and the effect on national income from their depletion and degradation. It will develop approaches to incorporating n ....Natural resources and ecosystem services in productivity measurement. This project aims to understand sources of productivity growth through addressing theoretical and practical problems in the economics of natural resources and ecosystem services. It will study the valuation of non-renewable resources and ecosystem services, acknowledging their contributions to economic activity and the effect on national income from their depletion and degradation. It will develop approaches to incorporating natural resource depletion and degradation into productivity analysis with the aim of better informing environmental, innovation and industry policy.Read moreRead less