Optimising Respiratory Care Of The Preterm Infant Using Regional Volumetric Strategies
Funder
National Health and Medical Research Council
Funding Amount
$282,086.00
Summary
Preterm birth is defined by the fragile under-developed lung needing to engage in air-breathing. Most preterm babies need respiratory support, but used inappropriately these life-saving therapies can increase the risk of long-term lung injury. This Fellowship will support a program designed to generate clinically meaningful outcomes through molecular, translational and clinical studies founded on strong physiological and biological principles and innovative research techniques.
Unlocking The Complexities Of Postnatal Brain Injury In Preterm Neonates.
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Brain injury is common in preterm infants and is responsible for significant death or life long disease such as cerebral palsy. Brain injury can occur through many mechanisms however the immediate newborn period is identified as a most vulnerable period. This unique proposal utilises existing expertise and new technologies to advance our understanding of the physiological mechanisms behind the progression of brain injury in preterm neonates.
Improving Lung Protective Mechanical Ventilation In The Newborn Using Regional Lung Mechanics
Funder
National Health and Medical Research Council
Funding Amount
$249,130.00
Summary
Premature babies are at risk of severe, and potentially long-term, lung damage. These complications can be minimised if babies lungs are optimally supported from birth. Dr Tingay will examine the influence of different strategies for using mechanical ventilators to help inflate the lung at birth, and their interactions with other therapies used to enhance lung maturity, using exciting new imaging technologies. It will provide new insights into helping vulnerable preterm babies.
Structural And Mechanical Determinants Of Airway Hyperresponsiveness
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
In asthma and chronic obstructive pulmonary disease, the capacity for airway passages to narrow is increased which limits airflow in and out of the lung and contributes to disease severity. The aim of this project is to identify the underlying physiological abnormalities producing the increased narrowing capacity. The investigations will focus on the role of the airway smooth muscle and epithelial layers that are widely implicated in driving the increased narrowing response, but for which the ev ....In asthma and chronic obstructive pulmonary disease, the capacity for airway passages to narrow is increased which limits airflow in and out of the lung and contributes to disease severity. The aim of this project is to identify the underlying physiological abnormalities producing the increased narrowing capacity. The investigations will focus on the role of the airway smooth muscle and epithelial layers that are widely implicated in driving the increased narrowing response, but for which the evidence remains circumstantial.Read moreRead less
Understanding The Regulation Of Cell Polarity In Development And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.
Vestibulo-ocular Reflex Physiology, Pathology And Diagnosis.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
A sensation of movement from the inner ear is used to stabilise vision during head movements. Without it, every time you walk, run, or drive on a bumpy road, the world would appear to bounce. It can be debilitating when this sense doesn't work due to various diseases. This research examines what causes these disorders and how the brain responds to help recovery. A diagnostic technique, that we will develop for wide clinical use, will be used to assess and identify treatments.