Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
An Implementation Trial Of A Telephone-based Care Management Program For Patients Following Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$641,656.00
Summary
We are trialling the implementation of an innovative telephone-delivered program for managing people who have had a heart attack. Cardiac rehabilitation programs are generally based in hospitals in Australia and people have to be able to attend the programs when they are offered. Even though such programs have been shown to be very effective in improving outcomes after a heart attack, at least 85% of Australians after a heart attack are either unable to access and-or unable to attend such progra ....We are trialling the implementation of an innovative telephone-delivered program for managing people who have had a heart attack. Cardiac rehabilitation programs are generally based in hospitals in Australia and people have to be able to attend the programs when they are offered. Even though such programs have been shown to be very effective in improving outcomes after a heart attack, at least 85% of Australians after a heart attack are either unable to access and-or unable to attend such programs due to transport and many other barriers. So, there is an urgent need to identify new, effective, and affordable ways of delivering cardiac rehabilitation programs to people after a heart attack. The proposed telephone-delivered program will be particularly appropriate for disadvantaged people, such as those living in rural and remote areas as well as Indigenous Australians, who do not currently have access to hospital-based cardiac rehabilitation programs. People who have had a heart attack will be recruited from three of Brisbane's largest public teaching hospitals, and will then be randomly assigned to the telephone-delivered cardiac rehabilitation program (Care Management Intervention group) or to a control or Usual Care group. The Care Management Intervention group will receive regular telephone calls from a highly qualified 'Care Manager' based at the renowned National Heart Foundation of Australia telephone support service, 'Heartline'. The Care Manager will help people to manage their heart condition and prevent the reoccurrence of further heart problems. People will also be encouraged to make necessary lifestyle and behavioural changes with the assistance of the Care Manager and some Heart Foundation educational and interactive resources to record their progress. We expect that the program or Care Management Intervention group will have better health outcomes than the control or Usual Care group at 6 and 12 months follow up.Read moreRead less
The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
Developmental Schizotypy In The General Population: Early Risk Factors And Predictive Utility.
Funder
National Health and Medical Research Council
Funding Amount
$830,952.00
Summary
This study will determine early childhood risk factors for psychosis-proneness in children aged 11 years, and emerging signs and symptoms of mental health disorders of these children, using population data from the NSW Child Development Study. Determining risk for psychosis as early as possible in the life course will enable the provision of preventative interventions to children at critical points in development.
Psychosocial Aspects Of Genomic Testing For Breast Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
Assessing a woman’s breast cancer risk by profiling polygenic risk represents a new approach in the familial cancer setting. My study is part of a program of research that aims to facilitate translation of polygenic risk information into clinical practice. For this, I will invite 400 women to receive their personal polygenic result and i) assess interest in receiving this result; ii) assess psychological and behavioural outcomes of receiving or not receiving their personal polygenic risk result
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Indigenous Network Suicide Intervention Skills Training (INSIST): Can A Community Designed And Delivered Framework Reduce Suicide/self-harm In Indigenous Youth?
Funder
National Health and Medical Research Council
Funding Amount
$828,215.00
Summary
Queensland has the highest rates of youth suicide in Australia. Indigenous youth suicide rates are reported at twice the rate of Queensland’s total population for 15 to 44 years. Statistical data on urban-rural differences in Australia have only been available since 1986 (ABS, 1994). Although the number of suicides is far greater in urban areas (1,299 suicides aged 10–24 years in metropolitan areas versus 311 in towns with populations less than 4,000), rural demonstrate greater suicide rates per
Nanoengineered, Encapsulated Catalysts from Fly Ash Waste. This project aims to deliver advanced catalysts and novel catalyst synthesis methods from the use of iron-rich fly ash, an otherwise abundant valueless waste with projected steady growth across Australia and globally. The as-synthesised catalysts are expected to be applicable to and exhibit excellent activity in the production of green hydrogen and renewable bio-fuels from lignocellulosic waste. These efforts are significant and benefici ....Nanoengineered, Encapsulated Catalysts from Fly Ash Waste. This project aims to deliver advanced catalysts and novel catalyst synthesis methods from the use of iron-rich fly ash, an otherwise abundant valueless waste with projected steady growth across Australia and globally. The as-synthesised catalysts are expected to be applicable to and exhibit excellent activity in the production of green hydrogen and renewable bio-fuels from lignocellulosic waste. These efforts are significant and beneficial in restoring the manufacturing capability of Australian industry, driving Australian industry towards the development of a circular economy for the appropriate management of solid waste, as well as for a seamless introduction of renewable and clean energy sources to address the pressing climate change.Read moreRead less
Chemicals in compostable food contact paper packaging materials. The aim of this project is to understand the presence of persistent chemicals in recyclable and compostable food contact materials (FCMs). These types of products are destined for recycling or biowaste streams that bridge the gap from take-make-dispose and into a circular economy. Currently, the knowledge of the chemicals in these products is limited but we need to ensure that they are safe and do not unnecessarily contaminate reso ....Chemicals in compostable food contact paper packaging materials. The aim of this project is to understand the presence of persistent chemicals in recyclable and compostable food contact materials (FCMs). These types of products are destined for recycling or biowaste streams that bridge the gap from take-make-dispose and into a circular economy. Currently, the knowledge of the chemicals in these products is limited but we need to ensure that they are safe and do not unnecessarily contaminate resource recovery streams. It is expected that this project will develop a framework that could be used by industry and government to prevent chemicals of concern persisting in a circular economy, providing environmental and economic benefits through reduced risk of chemical exposure and unnecessary remediation costs.Read moreRead less