Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.
SGLT2 inhibitors are new glucose-lowering agents for type 2 diabetes. They promote glucose loss into urine, which lowers blood glucose levels. However, little is known regarding the changes to kidney physiology when this system is manipulated with these drugs. There is evidence that SGLT2 inhibitors do not protect against kidney disease in diabetic mice, despite being an effective blood glucose-lowering agent. I aim to characterise the changes to kidney function upon SGLT2 blockade in diabetes.
A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.
Repurposing urban construction waste to create diverse wildflower meadows. Wildflower meadows have been planted extensively in European cities for aesthetic and biodiversity benefits. In SE Australia, they are stunning, but rare, features of critically endangered grassy woodlands because most native wildflowers cannot cope with intense grazing and high soil nutrients associated with agriculture. This project aims to develop a novel process for establishing native wildflower meadows in urban park ....Repurposing urban construction waste to create diverse wildflower meadows. Wildflower meadows have been planted extensively in European cities for aesthetic and biodiversity benefits. In SE Australia, they are stunning, but rare, features of critically endangered grassy woodlands because most native wildflowers cannot cope with intense grazing and high soil nutrients associated with agriculture. This project aims to develop a novel process for establishing native wildflower meadows in urban parks and degraded grassy woodlands by repurposing low nutrient mineral waste from the construction industry. It will have multiple benefits including restoring urban biodiversity, increasing people's mental well-being, developing new markets for recycled construction waste and reducing the amount of waste going to landfill. Read moreRead less
Nanoengineered, Encapsulated Catalysts from Fly Ash Waste. This project aims to deliver advanced catalysts and novel catalyst synthesis methods from the use of iron-rich fly ash, an otherwise abundant valueless waste with projected steady growth across Australia and globally. The as-synthesised catalysts are expected to be applicable to and exhibit excellent activity in the production of green hydrogen and renewable bio-fuels from lignocellulosic waste. These efforts are significant and benefici ....Nanoengineered, Encapsulated Catalysts from Fly Ash Waste. This project aims to deliver advanced catalysts and novel catalyst synthesis methods from the use of iron-rich fly ash, an otherwise abundant valueless waste with projected steady growth across Australia and globally. The as-synthesised catalysts are expected to be applicable to and exhibit excellent activity in the production of green hydrogen and renewable bio-fuels from lignocellulosic waste. These efforts are significant and beneficial in restoring the manufacturing capability of Australian industry, driving Australian industry towards the development of a circular economy for the appropriate management of solid waste, as well as for a seamless introduction of renewable and clean energy sources to address the pressing climate change.Read moreRead less