Protecting Australia And The Region From Emerging And Re-emerging Infectious Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The world is facing unprecedented threats from epidemics. In 2014 Ebola showed that issues such as quarantine, personal protective equipment and improved health system capacity are just as critical as drugs and vaccines, yet these are under-researched. Professor MacIntyre is an international expert epidemic control. She will lead a strategic research program to improve control of emerging and re-emerging infections, using her expertise in vaccines, personal protective equipment and biosecurity.
Central Aortic Blood Pressure In Children: Establishing A Gold Standard Non-invasive Assessment Of Cardiovascular Risk
Funder
National Health and Medical Research Council
Funding Amount
$694,342.00
Summary
The best way of assessing early risk of cardiovascular disease involves measuring blood pressure near the heart (central pressure), but existing devices used in adults for this purpose are inaccurate in children. We will develop a children-specific method and apply it to study early cardiovascular risk in a comprehensive health study of 2000 children Australia-wide. We will also investigate why children with congenital heart disease frequently develop ‘older-adult’ heart disease at a young age.
Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
TB is a global public health problem, responsible for the deaths of 2 million children and young adults annually. Drug resistant strains of TB are emerging and pose a threat even in countries where TB is well controlled, such as Australia. Research undertaken in this CRE will translate into improved treatments, diagnostics and strategies to prevent transmission. The CRE will build capacity for research on TB in our region and provide a legal framework to support public health policy.
Seeing Change: Science, Culture and Technology in the Antipodes from the age of Darwin - a multi-media research collaboration. To build a collaboration across the humanities, natural sciences, business technology and public culture sectors that will use new forms of digital and visual research to demonstrate the neglected importance of Australasia in the formation of nineteenth-century evolutionary thought and to suggest the relevance of these ideas to understanding contemporary issues of enviro ....Seeing Change: Science, Culture and Technology in the Antipodes from the age of Darwin - a multi-media research collaboration. To build a collaboration across the humanities, natural sciences, business technology and public culture sectors that will use new forms of digital and visual research to demonstrate the neglected importance of Australasia in the formation of nineteenth-century evolutionary thought and to suggest the relevance of these ideas to understanding contemporary issues of environmental sustainability and the development of frontier technologies within our society and region. Read moreRead less
Reshaping superannuation practice in Australia using big data analytics. This project aims to reform superannuation investment practices in Australia. Using sophisticated data analytics and machine-learning techniques, combined with economic modelling and quantitative finance. The project will try to understand the broad characteristics of Australian superannuation investors and their practice from a ‘big data’ perspective. The expected outcomes of this project are the identification of key dete ....Reshaping superannuation practice in Australia using big data analytics. This project aims to reform superannuation investment practices in Australia. Using sophisticated data analytics and machine-learning techniques, combined with economic modelling and quantitative finance. The project will try to understand the broad characteristics of Australian superannuation investors and their practice from a ‘big data’ perspective. The expected outcomes of this project are the identification of key determinants for successful superannuation behaviour to inform decision-making for better superannuation practices and policies. It is expected that the insights arising from this project will contribute to safeguarding the future of Australia’s superannuation schemes, and to better financial security at retirement.Read moreRead less
Soundness-guided security analysis for android applications. This project aims to develop a soundness-guided programme analysis to mitigate security threats caused by reflection and dynamic class loading in Android apps, without compromising precision and scalability. Both dynamic code update techniques are widely used in benign and malware apps, but state-of-the-art malware analysis tools ignore or mishandle them, missing security threats and vulnerabilities. The resulting open-source security ....Soundness-guided security analysis for android applications. This project aims to develop a soundness-guided programme analysis to mitigate security threats caused by reflection and dynamic class loading in Android apps, without compromising precision and scalability. Both dynamic code update techniques are widely used in benign and malware apps, but state-of-the-art malware analysis tools ignore or mishandle them, missing security threats and vulnerabilities. The resulting open-source security analysis tool will allow software industries and enterprises (from national security, finance, banking to healthcare, retail, telecommunications) to test their mobile software effectively for code defects or security threats early at software development time at significantly reduced cost.Read moreRead less
Micro Compilers: An Extensible Compiler Architecture for Increased Flexibility and Safety. Programming languages specialised to a particular application domain can cut software development costs and reduce programming errors. Unfortunately, most application domains cannot sustain the costly development and maintenance of the specialised compilers required to implement specialised languages. We address this problem by introducing a novel customisable compiler architecture that can be adapted to ....Micro Compilers: An Extensible Compiler Architecture for Increased Flexibility and Safety. Programming languages specialised to a particular application domain can cut software development costs and reduce programming errors. Unfortunately, most application domains cannot sustain the costly development and maintenance of the specialised compilers required to implement specialised languages. We address this problem by introducing a novel customisable compiler architecture that can be adapted to specialised languages and other special-purpose compiler requirements. Customisable compilers are especially important to a country like Australia that has only limited resources for special purpose developments. Moreover, we will train students at undergraduate and postgraduate level in the area of programming languages and compilers.Read moreRead less
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
Improving the Performance, Scalability and Reliability of the Linux Operating System. This project aims to improve the scalability of the Linux operating system to large systems without loss of performance on small, embedded, systems. It will improve Linux robustness and security by de-privileging particularly error-prone code, such as device drivers, without undue impact on performance. It will improve configurability and ease tuning by making critical components, such as processor, disk and me ....Improving the Performance, Scalability and Reliability of the Linux Operating System. This project aims to improve the scalability of the Linux operating system to large systems without loss of performance on small, embedded, systems. It will improve Linux robustness and security by de-privileging particularly error-prone code, such as device drivers, without undue impact on performance. It will improve configurability and ease tuning by making critical components, such as processor, disk and memory schedulers, pluggable and their policies controllable at user level. It will investigate the feasibility and benefits of user-level file systems and processor and memory scheduling and will demonstrate that these can improve system reliability without undermining performance.Read moreRead less