Novel test and design methods for base course reinforced flexible pavements. This project aims to develop the mechanics of geosynthetic-reinforced flexible pavements as an urgent need for the Australian pavement industry to build more sustainable and economical roads. Novel laboratory test apparatus and in-situ test programs, and mathematical models will be developed, for the first time, to capture the responses of reinforced base courses in a complete and optimised way to determine the paramete ....Novel test and design methods for base course reinforced flexible pavements. This project aims to develop the mechanics of geosynthetic-reinforced flexible pavements as an urgent need for the Australian pavement industry to build more sustainable and economical roads. Novel laboratory test apparatus and in-situ test programs, and mathematical models will be developed, for the first time, to capture the responses of reinforced base courses in a complete and optimised way to determine the parameters for pavement design and performance evaluation. The outcomes will enable reliable prediction of reinforced pavement behaviour, leading to better-performing geosynthetic products and more resilient pavements, reduced material usage and damage in pavements, and less environmental impact and maintenance cost.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australi ....Managing and mitigating social risks of major infrastructure projects. This project aims to reduce social risks of major infrastructure projects by generating an evidence-based social risk management framework. It brings together leading ANU researchers with top organisations in Australia's infrastructure sector, already working together via the ANU Institute for Infrastructure in Society. The project seeks to improve social risk management in a multi-billion dollar sector, vital to all Australians. The project is significant because it adopts a sector-wide view to systematically define social risk, co-create a social risk management framework and implement it via a new social risk management toolkit. This should lessen harm to communities, reduce delays and costs and benefit national infrastructure delivery.Read moreRead less
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less