Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to ....Plant immunity to fungal and bacterial pathogens. Since 2003, the Australian wheat crop has been threatened by a continuing stripe rust epidemic, which has required an additional production expense of at least $100 million per annum in fungicides. This Australian National University (ANU) - Commonwealth Scientific and Industrial Research Organisation (CSIRO) joint proposal aims to exploit the next-generation genome sequencing and associated bioinformatic and proteomic methods which are poised to revolutionise biology to investigate the wheat-fungus interaction. We will develop new effective approaches for environmentally benign stripe rust control based on new knowledge about how this fungus causes disease and avoids the wheat's immune surveillance system.Read moreRead less
Data sharing with strong privacy against inference attacks. This project aims to develop theories and techniques for strong protection of personal information in sharing large datasets such as national health data or census records. It intends to achieve this through developing new information theoretic methods for synthesising datasets with proven high fidelity and protection against re-identification and inference attacks, where attackers try to learn probability of sensitive data. The expecte ....Data sharing with strong privacy against inference attacks. This project aims to develop theories and techniques for strong protection of personal information in sharing large datasets such as national health data or census records. It intends to achieve this through developing new information theoretic methods for synthesising datasets with proven high fidelity and protection against re-identification and inference attacks, where attackers try to learn probability of sensitive data. The expected outcomes are algorithms for public and private sector data curators to dial up or down their data access arrangements based on privacy risks and fidelity demands linked with different data types and uses. This project intends to enable Australians to securely benefit from valuable data in decision making.Read moreRead less
Explicit methods in number theory: Computation, theory and application. This project aims to use explicit estimates to unify three problems in number theory: primitive roots, Diophantine quintuples, and linear independence of zeroes of the Riemann zeta-function. It will use computational and analytic number theory to reduce the quintuples problem to a soluble level. Pursuing relations between the zeta zeroes will overhaul many current results. This project will apply its findings about primitive ....Explicit methods in number theory: Computation, theory and application. This project aims to use explicit estimates to unify three problems in number theory: primitive roots, Diophantine quintuples, and linear independence of zeroes of the Riemann zeta-function. It will use computational and analytic number theory to reduce the quintuples problem to a soluble level. Pursuing relations between the zeta zeroes will overhaul many current results. This project will apply its findings about primitive roots to signal processing, cryptography and cybersecurity.Read moreRead less
Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normal ....Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normally controlled and how it can be manipulated industrially. This should provide significant benefits, impacting stem cell biology (improving stem cell production), tissue engineering (improving growth of artificial tissues), veterinary science and agriculture (improving productivity).Read moreRead less