Biologically Inspired Binaural Coupling for Selective Machine Hearing. This project aims to investigate biologically-inspired binaural coupling models in the context of the deep learning paradigm by formulating desirable higher level auditory structures as neural network sub-systems. This project expects to generate new knowledge for developing the next generation of robust speech processing systems that are capable of mimicking the selecting listening ability of humans when faced with realistic ....Biologically Inspired Binaural Coupling for Selective Machine Hearing. This project aims to investigate biologically-inspired binaural coupling models in the context of the deep learning paradigm by formulating desirable higher level auditory structures as neural network sub-systems. This project expects to generate new knowledge for developing the next generation of robust speech processing systems that are capable of mimicking the selecting listening ability of humans when faced with realistic noisy speech signals and the ‘cocktail party problem’ using innovative binaural feedback systems. This work should provide significant benefits, including improved voice biometrics and selective auditory attention capabilities in machines.Read moreRead less
Drone-based Communications for High-speed Beyond 5G Wireless Systems. Drone-based communication is a revolutionised wireless paradigm for the development of highly flexible and cost-effective beyond fifth-generation (B5G) wireless systems. This project aims to develop novel communication theories and practical techniques to realise truly high-speed and ubiquitous communication required in B5G networks. The project intends to deliver resource allocation designs, robust transceiver designs and a s ....Drone-based Communications for High-speed Beyond 5G Wireless Systems. Drone-based communication is a revolutionised wireless paradigm for the development of highly flexible and cost-effective beyond fifth-generation (B5G) wireless systems. This project aims to develop novel communication theories and practical techniques to realise truly high-speed and ubiquitous communication required in B5G networks. The project intends to deliver resource allocation designs, robust transceiver designs and a system-level analysis as the foundations and tools to unlock the potential of this promising paradigm. The outcomes of this project are expected to fundamentally advance the knowledge of drone-based communications with significant economic values to service providers and benefits to mobile users over the world.Read moreRead less
The role of phosphoinositides in endosomal maturation dynamics. This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput pro ....The role of phosphoinositides in endosomal maturation dynamics. This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.Read moreRead less
Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that h ....Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that has previously been overlooked. This project aims to understand how this pathway works and how it contributes to the normal workings of cells. This fundamental science has future consequences for the design of vaccines and for the design of therapeutics to treat diseases that show defective interferon signalling.Read moreRead less
Human-Unmanned Aerial Vehicle interactions: Making drones talk and listen. This project aims to develop audio technology to enable unmanned aerial vehicles or drones to hear, use speech and sound to communicate with humans, acoustically sense their surroundings and make them less noisy. This project expects to generate new knowledge in acoustic signal processing and its application in drones using innovative approaches, such as use of miniature microphone and loudspeaker arrays, and active noise ....Human-Unmanned Aerial Vehicle interactions: Making drones talk and listen. This project aims to develop audio technology to enable unmanned aerial vehicles or drones to hear, use speech and sound to communicate with humans, acoustically sense their surroundings and make them less noisy. This project expects to generate new knowledge in acoustic signal processing and its application in drones using innovative approaches, such as use of miniature microphone and loudspeaker arrays, and active noise control. Expected outcomes include development of new theories, Intellectual Property, with potential commercial value, and training of next generation researchers. This should provide significant benefits with applications in life saving, search and rescue operations, transportation of goods, and creation of 3D media.Read moreRead less
Tuning the activating stimulus of voltage-gated sodium channels. This proposal aims to advance fundamental knowledge about how proteins (ion channels) found on the surface of neurons (brain cells and nerves) function as molecular conduits of cell-to-cell electrical communication. We aim to study how molecular probes and structural parts of these proteins affect the local chemical environment of ion channels, and how this leads to fine tuning of the ion channel's sensitivity to the stimulus that ....Tuning the activating stimulus of voltage-gated sodium channels. This proposal aims to advance fundamental knowledge about how proteins (ion channels) found on the surface of neurons (brain cells and nerves) function as molecular conduits of cell-to-cell electrical communication. We aim to study how molecular probes and structural parts of these proteins affect the local chemical environment of ion channels, and how this leads to fine tuning of the ion channel's sensitivity to the stimulus that activates them (cell membrane voltage).
The conceptual knowledge gained from this project would advance our understanding of a fundamental physiological process and facilitate the development of drugs that regulate ion channel function, such as anti-epileptics, analgesics and insecticides.Read moreRead less
Ultra-reliable and low-latency mission critical communications. This project aims to develop enabling technologies for ultra-reliable and low-latency communications. While the evolution of wireless communication technologies to date has focused on data rate improvement, very little is known on how to achieve ultra-reliability and almost-zero latency which is urgently required for mission critical applications such as smart manufacturing and intelligent vehicles. The outcomes of the project will ....Ultra-reliable and low-latency mission critical communications. This project aims to develop enabling technologies for ultra-reliable and low-latency communications. While the evolution of wireless communication technologies to date has focused on data rate improvement, very little is known on how to achieve ultra-reliability and almost-zero latency which is urgently required for mission critical applications such as smart manufacturing and intelligent vehicles. The outcomes of the project will be new analytical tools and practical guidelines for designing trusted communication platforms to realise these applications, with benefits ranging from improved safety in intelligent transportation systems to digital transformation of the manufacturing industry.Read moreRead less
Mitochondria as sensors of environmental threats. This project aims to understand how energy-generating mitochondria control immune responses, both in immune cells called macrophages and in the nematode Caenorhabditis elegans (a free-living roundworm used as a model organism to study gene function and evolutionary biology). The project expects to advance knowledge of how a process called mitochondrial fission enables cells to respond to environmental threats. Expected outcomes include important ....Mitochondria as sensors of environmental threats. This project aims to understand how energy-generating mitochondria control immune responses, both in immune cells called macrophages and in the nematode Caenorhabditis elegans (a free-living roundworm used as a model organism to study gene function and evolutionary biology). The project expects to advance knowledge of how a process called mitochondrial fission enables cells to respond to environmental threats. Expected outcomes include important conceptual advances in cell biology and genetics, new international and national collaborations, and improved methods for cell biology research. Anticipated benefits include a knowledge base that can be indirectly applied in the long term in the development of new strategies to combat infections.Read moreRead less
Passive Positioning and Tracking of Flying Objects Using Satellite Signals. Along with the deployment of low Earth orbit satellite constellations for global satellite Internet services, such as Starlink, Ku/Ka/V band microwave signals from space will be available anywhere on Earth 24/7. Utilising the microwave signals, this project aims to investigate a high-resolution cost-effective solution to position and track un-cooperative flying objects, and expects to generate new knowledge in the area o ....Passive Positioning and Tracking of Flying Objects Using Satellite Signals. Along with the deployment of low Earth orbit satellite constellations for global satellite Internet services, such as Starlink, Ku/Ka/V band microwave signals from space will be available anywhere on Earth 24/7. Utilising the microwave signals, this project aims to investigate a high-resolution cost-effective solution to position and track un-cooperative flying objects, and expects to generate new knowledge in the area of remote sensing and to make Australia the leader in passive flying objects positioning and tracking. This should provide significant benefits, such as enabling new applications for future drone delivery systems or aerial taxi services, and benefiting the air transport industry, the defence industry, and bird conservation.Read moreRead less
An active ion transport pathway exploited by coronaviruses. Cells have active transport “pumps” that are regulators of a variety of cellular processes. This project aims to understand how a specific ion pump is exploited by coronaviruses when they infect animal cells. These studies will provide new mechanistic insights into how coronaviruses alter calcium signalling in cells and how a specific ion pump regulates a variety of key processes during coronavirus infection. This work will greatly enha ....An active ion transport pathway exploited by coronaviruses. Cells have active transport “pumps” that are regulators of a variety of cellular processes. This project aims to understand how a specific ion pump is exploited by coronaviruses when they infect animal cells. These studies will provide new mechanistic insights into how coronaviruses alter calcium signalling in cells and how a specific ion pump regulates a variety of key processes during coronavirus infection. This work will greatly enhance our understanding of the intersection between ion pumps and viruses.Read moreRead less