Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinicia ....Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinician to reduce fetal deaths and enhance the chances of good outcomes with resultant savings in social and financial costs to the community. The development of such equipment would spawn future research into intervention treatments and contribute to Australia's position as a world leader in computerised health monitoring systems.Read moreRead less
Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communicat ....Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communications aspects. We also build a core expertise in optimisation and its applications in Australia by training PhD students and Postdoctoral researchers. The research collaborations will cement and maintain the international linkages which will improve applied research in AustraliaRead moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Fundamentals of Damage Identification in Tubular Structures Using Guided Waves. This project addresses fundamental but frontier issues and techniques that will lead to ultimate solutions for online integrity/safety assessment of tubular engineering structures. The most important outcome will be the development of fundamental knowledge and algorithms of guided wave-based damage identification in tubular structures in applications, putting Australia at the international forefront of techniques in ....Fundamentals of Damage Identification in Tubular Structures Using Guided Waves. This project addresses fundamental but frontier issues and techniques that will lead to ultimate solutions for online integrity/safety assessment of tubular engineering structures. The most important outcome will be the development of fundamental knowledge and algorithms of guided wave-based damage identification in tubular structures in applications, putting Australia at the international forefront of techniques in efficient asset maintenance and management. This project focuses on cutting-edge technologies, including sensor networks with signal filtering/processing and software/hardware integration, which will incubate the commercialisation of practical sensor networks, benefiting the intellectual leadership of Australia.Read moreRead less
Imaging the T cell signalling machinery . The conversion of external stimuli to the interior of a cell is a fundamental process that underpins many unique facets of biology, including cellular movement, nerve transmission, response to hormones and immune recognition. However, the basic mechanism by which such signals are transmitted across cellular membranes is poorly understood. This proposal will seek to bridge this gap in our knowledge by imaging a multi-component “decision-making” machine th ....Imaging the T cell signalling machinery . The conversion of external stimuli to the interior of a cell is a fundamental process that underpins many unique facets of biology, including cellular movement, nerve transmission, response to hormones and immune recognition. However, the basic mechanism by which such signals are transmitted across cellular membranes is poorly understood. This proposal will seek to bridge this gap in our knowledge by imaging a multi-component “decision-making” machine that controls whether or not the immune system becomes activated. Accordingly, this proposal will provide far-reaching insights into molecular events that are of central importance to the initiation of immunity, and thus will ultimately benefit society via improvements in health.Read moreRead less
Semantic Vectorisation: From Bitmaps to Intelligent Representations. The objective of this innovative project is to provide a solution to the open question of representing natural images by semantically rich vector graphics. The challenges are to identify key visual and temporal elements for images and videos, and efficiently decompose the visual data into semantic vector representations that are faithful to original data, compact and editable. The project aims to investigate new bitmap-to-vecto ....Semantic Vectorisation: From Bitmaps to Intelligent Representations. The objective of this innovative project is to provide a solution to the open question of representing natural images by semantically rich vector graphics. The challenges are to identify key visual and temporal elements for images and videos, and efficiently decompose the visual data into semantic vector representations that are faithful to original data, compact and editable. The project aims to investigate new bitmap-to-vector conversion methods. It is expected to develop a framework where semantic labels and hyperlinks can be embedded in visual data automatically. It hopes to pioneer the creation of a web of images where the links are on image/video regions. New image simplification, stylisation, and non-photorealistic rendering methods are expected to be provided.Read moreRead less
Efficient multi-view video coding with cuboids and base anchored models. This project aims to address current deficiencies in multi-view video coding technology to achieve the ultra-compression efficiency demanded by increasing display resolutions and synchronised viewpoints. The project expects to generate new knowledge, by moving from the current pixel-centric approach to methods that concentrate information common to many view-frames. The project is expected to improve compression of audio-vi ....Efficient multi-view video coding with cuboids and base anchored models. This project aims to address current deficiencies in multi-view video coding technology to achieve the ultra-compression efficiency demanded by increasing display resolutions and synchronised viewpoints. The project expects to generate new knowledge, by moving from the current pixel-centric approach to methods that concentrate information common to many view-frames. The project is expected to improve compression of audio-visual services that are of great interest to international standards bodies and industry, while facilitating free interaction and augmented reality. This project will provide significant benefits to broadcast, entertainment, surveillance and health industries and position Australia as a world leader in this field.Read moreRead less
The combined use of proteomics and small molecules for target identification and pathway analysis. This project intends to investigate how a series of new small molecules identified from our research to improve the metabolic effects of insulin. This project will integrate medicinal chemistry with proteomics and metabolic biology to identify the cellular targets and their mechanism of action.