Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0236372
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
CENTRIFUGATION FACILITIES FOR THE GENETICS ANALYSIS FACILITY. Access to both a high-speed centrifuge and an ultracentrifuge is essential for a wide range of biochemistry and molecular biology research projects. A high-speed centrifuge is essential for the collection of bacteria cultured to express specific proteins as well as the collection of purified proteins isolated from a wide range of organisms. Similarly an ultracentrifuge is required for the isolation of viruses and the preparation and p ....CENTRIFUGATION FACILITIES FOR THE GENETICS ANALYSIS FACILITY. Access to both a high-speed centrifuge and an ultracentrifuge is essential for a wide range of biochemistry and molecular biology research projects. A high-speed centrifuge is essential for the collection of bacteria cultured to express specific proteins as well as the collection of purified proteins isolated from a wide range of organisms. Similarly an ultracentrifuge is required for the isolation of viruses and the preparation and purification of RNA and DNA. The two machines will facilitate the continuation of research projects funded by both government and industry grants. The centrifuges will complement the equipment available in the Genetic Analysis Facility.Read moreRead less
New Methods for Directed Molecular Evolution of Novel Protein Functions. Novel ribosome-based techniques can be used to carry out test-tube evolution of proteins with new structures and functions. The methods rely on (a) physical association of individual nucleic acid molecules with the particular protein molecules they encode, (b) selection of proteins with new functions, and (c) recovery of the attached genetic code. This project will address several issues that currently limit use of these fr ....New Methods for Directed Molecular Evolution of Novel Protein Functions. Novel ribosome-based techniques can be used to carry out test-tube evolution of proteins with new structures and functions. The methods rely on (a) physical association of individual nucleic acid molecules with the particular protein molecules they encode, (b) selection of proteins with new functions, and (c) recovery of the attached genetic code. This project will address several issues that currently limit use of these frontier technologies for evolution of new protein products that have a wide range of practical applications.Read moreRead less