Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease. Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.
A novel role for phytochrome in dormancy release inhibition. Seed dormancy contributes to the persistence of weeds in agriculture by enabling seeds to remain viable in the soil for many years, and is a major reason why annual ryegrass (Lolium rigidum) has become the most economically damaging weed in Australian agriculture. Recently we discovered a new way to control dormancy release and germination in these seeds. This project to identify the changes occurring within the seeds during dormancy r ....A novel role for phytochrome in dormancy release inhibition. Seed dormancy contributes to the persistence of weeds in agriculture by enabling seeds to remain viable in the soil for many years, and is a major reason why annual ryegrass (Lolium rigidum) has become the most economically damaging weed in Australian agriculture. Recently we discovered a new way to control dormancy release and germination in these seeds. This project to identify the changes occurring within the seeds during dormancy release will underpin our efforts to manipulate emergence timing in order to improve the efficacy of current weed control practices and contribute to sustainable farming systems.Read moreRead less
Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will m ....Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will make this possible by adapting calibration free measurement principles (coulometry, or charge counting) to this class of sensors, where a thin layer of sample solution will be depleted by instrumental control. This forms the scientific basis for successfully tackling the measurement challenges of the future.Read moreRead less
Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust r ....Understanding mosquito smell system: a new frontier in mosquito control. This project aims to identify and functionally investigate mosquito smell receptors, which are critical in detecting volatile compounds and locating their hosts from a considerable distance away. Mosquitoes display preferences for certain hosts over others, primarily determined by volatile chemicals produced by hosts. This study builds on recently discovered, novel, host-derived volatile compounds, which can elicit robust responses and attractiveness from mosquitoes. Expected outcomes of the project are enhanced understanding of mosquito smell system and behaviours. This could provide significant benefits to how we can fight mosquitoes and mosquito-transmitted diseases in a more efficient and environmentally responsible way.Read moreRead less
Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.