Practice- And Policy-relevant Research In Skin Cancer Epidemiology, Prevention And Screening
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
This Fellowship will enable me to lead an internationally-competitive program of research in skin cancer epidemiology, prevention & screening that will lead to improved patient and population health through impacts on clinical practice and health policy. My aim is to lead paradigm-shifting contributions in: ? Genetic epidemiology of melanoma, ? Precision skin cancer prevention & screening, and ? Public health genomics for cancer prevention.
Stem And Progenitor Cell Contribution To Skin Wounds And Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Skin wounds represent a major health and economic burden. Although skin stem cells have been used routinely for the treatment of wounds, they cannot reconstitute a fully functional skin given the complexity and the many cell types usually involved in wound healing. In this project, we intend to evaluate the role of different cell populations on modulating skin wound healing to produce more regeneration and less scaring.
Modulating Skin Regenerative Responses To Improve Wound Repair And Fight Carcinogenesis
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Skin disorders, such as hard to heal wounds or the most common skin cancers, are a major burden on the national health system. Despite their different nature they employ similar mechanisms of response to injury. In this project we intend to develop a comprehensive understanding of the genetic and molecular mechanisms at play to allow clinical interventions to prevent or to cure these disorders.
Integrating Behaviour Change And Technology Uptake Models Into Skin Cancer Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$459,271.00
Summary
Two in three Australians will develop skin cancer in their lifetime, and skin cancer incidence is expected to increase. Therefore optimal ways to prevent and early detect skin cancers are of utmost importance to Australia’s public. By integrating the latest behaviour change models and technology uptake models to develop innovative interventions, this fellowship aims to ascertain that all Australians regardless of their location have access to optimal skin cancer prevention and early detection ca ....Two in three Australians will develop skin cancer in their lifetime, and skin cancer incidence is expected to increase. Therefore optimal ways to prevent and early detect skin cancers are of utmost importance to Australia’s public. By integrating the latest behaviour change models and technology uptake models to develop innovative interventions, this fellowship aims to ascertain that all Australians regardless of their location have access to optimal skin cancer prevention and early detection care.Read moreRead less
Addressing Important Evidence Gaps In The Management Of Severe Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$256,839.00
Summary
There are currently large gaps in the evidence base for management of common severe bacterial infections. My research plan focuses on the most common of these: Staphylococcus aureus infections, bone and joint infections, skin infections, and severe sepsis. In order to both generate important evidence to inform practice, as well as to develop my own skills and experience as an expert in clinical trials, I have initiated randomised controlled trials in each of these areas.
Optimising Interventions For Staphylococcus Aureus And Skin Infections
Funder
National Health and Medical Research Council
Funding Amount
$338,381.00
Summary
Staphylococcal and streptococcal infections are major causes of illness and death, particularly in Indigenous Australians. These include invasive bloodstream infections and skin infections that lead to chronic kidney and heart disease. I will conduct clinical trials to optimise the management of staphylococcal bloodstream infections using novel trial methods, and use genomics and mathematical modelling to understand and reduce the burden of skin infections in Indigenous communities.