Absence Of CC Chemokine Receptor 6 Dysregulates The Humoral Immune Response.
Funder
National Health and Medical Research Council
Funding Amount
$524,820.00
Summary
The individual steps leading to the activation and differentiation of B cells and the formation of mature functional germinal centres have been investigated in detail and are well understood. In contrast, the underlying molecular signals, which regulate the different events and prevent either autoimmunity or immunodeficiency are still not fully comprehended. This proposal will address these regulatory steps that prevent autoimmunity.