A New Clinical Tool To Assess Fitness-to-drive In Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$727,963.00
Summary
Obstructive sleep apnoea (OSA) affects 1 in 4 middle aged adults. OSA results in impaired neurobehavioral function, excessive sleepiness, and more than 2-fold increased motor vehicle crash risk and workplace accidents. However, not all patients are impaired and identifying patients at risk is a daily clinical challenge. This project proposes new and simple measures that can accurately identify patients with OSA who are most vulnerable to alertness failure and motor vehicle accident risk.
Randomised Controlled Trial Of Melatonin For Delayed Sleep Phase Disorder
Funder
National Health and Medical Research Council
Funding Amount
$711,136.00
Summary
Delayed Sleep Phase Disorder (DSPD) is a sleep disorder affecting 7-16% of adolescents and young adults. It is associated with poor health and impaired academic and social functioning. We will test in a randomised controlled trial whether the hormone melatonin can be used as a treatment for DSPD. We will also assess whether genetic factors are linked to treatment outcome. The study will provide a much-needed standardised diagnostic and treatment approach for DSPD.
Mechanisms Of Gastroesophageal Reflux In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$462,214.00
Summary
The symptoms of gastroesophageal reflux (heartburn and acid burning) are extremely common in individuals with obstructive sleep apnoea (OSA), especially during sleep (nocturnal reflux). The reasons for this are unclear. This research project will investigate the reasons for this increased occurrence of reflux in OSA.
What Role Do Cerebral Hypoxia And Sleep Disruption Play In The Neurocognitive Effects Of Paediatric Sleep Disordered Breathing?
Funder
National Health and Medical Research Council
Funding Amount
$558,957.00
Summary
Sleep disordered breathing (SDB) describes a spectrum of disorders caused by obstruction of the upper airway during sleep from simple primary snoring (PS) to obstructive sleep apnoea (OSA). Findings of our recently studies have provided strong evidence that all levels of SDB severity including PS are associated with neurocognitive and behavioural deficits. In this study we will investigate the mechanisms of which underpin these deficits.
Hyper-sensitivity Of The Circadian System To Light In Delayed Sleep Phase Disorder
Funder
National Health and Medical Research Council
Funding Amount
$378,858.00
Summary
Delayed Sleep Phase Disorder (DSPD) is a circadian rhythm sleep disorder characterized by a difficulty in initiating sleep at night and difficulty in waking at times required for work or school. It is associated with excessive daytime sleepiness, reduced academic and work performance, increased anxiety and depression and reduced quality of life. This study examines increased sensitivity of the brain's 24-hour biological clock to light as a cause of the abnormal timing of sleep in DSPD.
Predicting Obstructive Sleep Apnoea Using 3D Craniofacial Photography
Funder
National Health and Medical Research Council
Funding Amount
$424,715.00
Summary
Sleep Apnoea is a common medical condition associated with snoring and collapse of the throat during sleep. Diagnosis of sleep apnoea involves an overnight sleep study in a specialised laboratory, which is expensive and time consuming. It is possible that sleep apnea could be diagnosed from a 3-dimensional photograph of the face. This study will define the relationships between sleep apnea and 3D face photographs in 956 young adults and 1,200 of their parents, and 3,000 sleep clinic patients.
The Evolution Of Childhood Obesity And Its Relationship To Adult Sleep Disordered Breathing
Funder
National Health and Medical Research Council
Funding Amount
$870,842.00
Summary
This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental pr ....This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental predictors that can inform public health policy.Read moreRead less
Researching Effective Sleep Treatments (Project REST): A Partner-Assisted Intervention To Improve Adherence In Cognitive Behavioural Therapy For Insomnia
Funder
National Health and Medical Research Council
Funding Amount
$1,130,307.00
Summary
Insomnia is highly prevalent and predicts many other mental and physical problems. While very good behavioural treatments exist for insomnia, not everyone is able to comply with the difficult behaviour changes required to improve. Bed partners often influence sleep behaviours, and thus, can play a helpful role in the treatment of insomnia, if they are taught how. We will test the first intervention ever developed integrating the partner into insomnia treatment as a means of improving outcomes.
Evaluating The Effect Of Morphine On Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$534,303.00
Summary
Prescription opiate poisoning deaths have increased substantially in recent years which may be worsened by population increases in obesity and related obstructive sleep apnea. However, no proper clinical trial has ever investigated the effect of an opiate on obstructive sleep apnea, which is the aim of the proposed trial. The study will be important in understanding ways to reduce opiate realted deaths and may also provide insights into new treatment methods for snoring and sleep apnea.
A Novel Optical Stimulation Method For Obstructive Sleep Apnoea Treatment
Funder
National Health and Medical Research Council
Funding Amount
$510,913.00
Summary
This project aims to develop and characterize a novel optogenetic pharyngeal stimulation system to dilate the upper airway using a light stimulus. This will provide proof-of-concept for a new minimally invasive treatment option for obstructive sleep apnoea.