Structures and Properties of beta-R3M (M = Si, Ge, Sn)- and beta-Chalcogenyl-substituted Carbenium Ions. The benefits of this work are many-fold. The scientific knowledge gained will be invaluable to all scientists working in organic chemistry; mechanistic chemists who will learn from the science, and synthetic organic chemists who can utilise the results when planning strategies for the synthesis of complex drugs. Another major benefit of this research is in the training of young scientists. Th ....Structures and Properties of beta-R3M (M = Si, Ge, Sn)- and beta-Chalcogenyl-substituted Carbenium Ions. The benefits of this work are many-fold. The scientific knowledge gained will be invaluable to all scientists working in organic chemistry; mechanistic chemists who will learn from the science, and synthetic organic chemists who can utilise the results when planning strategies for the synthesis of complex drugs. Another major benefit of this research is in the training of young scientists. The students who work on this proposal gain invaluable experience in many areas of chemistry, ranging from synthetic chemistry to structural chemistry and theoretical chemistry. They will also gain experience in important physical techniques from NMR spectroscopy to X-ray crystallography.Read moreRead less
Approaching anion solvation from the bottom up: infrared studies of negatively charged complexes and clusters. We will employ novel spectroscopic strategies to probe the structures of mass-selected anion complexes and clusters in the gas-phase with the purpose of exploring non-covalent forces responsible for anion solvation. The work is motivated by a recognition that anions serve as key participants in a host of natural and industrial chemical processes, and that their physical and chemical pro ....Approaching anion solvation from the bottom up: infrared studies of negatively charged complexes and clusters. We will employ novel spectroscopic strategies to probe the structures of mass-selected anion complexes and clusters in the gas-phase with the purpose of exploring non-covalent forces responsible for anion solvation. The work is motivated by a recognition that anions serve as key participants in a host of natural and industrial chemical processes, and that their physical and chemical properties depend critically upon interactions with solvent molecules. The experimental results should serve as a critical test for computational approaches to describing anion-neutral interactions, and provide new insights into the behaviour of electrolytes, acid-base chemistry, and fundamental bimolecular reactions.Read moreRead less
Novel Scanning Electrochemical Microscopy applications in molecular, supramolecular electrochemistry and biological systems. Improved understanding of chemical reactivity in natural and artificial molecular systems and acquisition of a wider perspective of electron transfer processes are two important challenges in chemistry and biology. Through this well defined research project, the CI, jointly with the host facility, has the skills to achieve valuable new insights. This project will expand Au ....Novel Scanning Electrochemical Microscopy applications in molecular, supramolecular electrochemistry and biological systems. Improved understanding of chemical reactivity in natural and artificial molecular systems and acquisition of a wider perspective of electron transfer processes are two important challenges in chemistry and biology. Through this well defined research project, the CI, jointly with the host facility, has the skills to achieve valuable new insights. This project will expand Australia's knowledge base and research capability and open new scenarios for frontier technologies and advanced materials. This project will introduce the SECM methods into Australia. The foreseen benefits include technology exchange and contribution to fundamental and applied science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989197
Funder
Australian Research Council
Funding Amount
$225,000.00
Summary
Reaction Kinetics Analysis Facility. This proposal will establish a world-class resource to support major research efforts in a wide range of applications associated with the study of reaction mechanisms and intermediates in systems ranging from small molecules to complex polymers. This facility, which is unique in Australia and strongly builds on the broad expertise of the involved researchers at the participating institutions, will address an important need in the areas of physical-organic and ....Reaction Kinetics Analysis Facility. This proposal will establish a world-class resource to support major research efforts in a wide range of applications associated with the study of reaction mechanisms and intermediates in systems ranging from small molecules to complex polymers. This facility, which is unique in Australia and strongly builds on the broad expertise of the involved researchers at the participating institutions, will address an important need in the areas of physical-organic and physical chemistry by strengthening our capacity for cutting-edge research in reactive intermediate chemistry. The Facility will help to establish frontier technologies in the chemical sciences for building and transforming Australian industries in line with national research priorities.Read moreRead less
Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catal ....Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catalytic processes and lead to increased profitability and/or a reduction in unwanted side products and pollution. The project will train young scientists in important experimental and theoretical chemical techniques, and will enhance and contribute to Australia's international research profile.Read moreRead less
Exploring new roles for phosphorus radicals in health, environment, and technology. Several practical outcomes will arise from this project. Information on processes that contribute to genetic disease and cancer will be derived through studies of the role of phosphorus radicals in DNA damage. Processes that lead to the degradation of natural and synthetic materials in the environment will be explored. Clean reactions will be developed for the fabrication of advanced materials (e.g. pharmaceutica ....Exploring new roles for phosphorus radicals in health, environment, and technology. Several practical outcomes will arise from this project. Information on processes that contribute to genetic disease and cancer will be derived through studies of the role of phosphorus radicals in DNA damage. Processes that lead to the degradation of natural and synthetic materials in the environment will be explored. Clean reactions will be developed for the fabrication of advanced materials (e.g. pharmaceuticals). These innovations will expand Australia's international profile in a growing research area. The project will also address three of Australia's National Research Priorities, contribute to the training of researchers in Free Radical Chemistry, and initiate research collaborations with institutions in France and the USA.Read moreRead less
Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opport ....Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opportunities for students to be trained in cutting-edge basic research. Knowledge and fundamental understanding of the damage of bio-surfaces caused by atmospheric free-radical oxidants and their potential role in ageing processes will help to develop novel medical strategies, which substantially contribute to the quality of Australian sciences.Read moreRead less
Exploring the Frontiers of Free-Radical Chemistry: Self-Terminating Radical Reactions. Self-terminating free-radical reactions are a new concept in the chemist's synthetic armory. This innovative technique, invented by the chief investigators, has enormous synthetic scope that is yet largely untapped. This proposal seeks to develop novel reactions based on this concept; to explore their generality and versatility in organic synthesis through the use of both laboratory and computational techniq ....Exploring the Frontiers of Free-Radical Chemistry: Self-Terminating Radical Reactions. Self-terminating free-radical reactions are a new concept in the chemist's synthetic armory. This innovative technique, invented by the chief investigators, has enormous synthetic scope that is yet largely untapped. This proposal seeks to develop novel reactions based on this concept; to explore their generality and versatility in organic synthesis through the use of both laboratory and computational techniques. In this manner, singificant contributions to frontier technologies and breakthrough science will be made.Read moreRead less
BIOSYNTHESIS OF A FUNGAL TOXIN AND ITS ROLE IN PLANT DISEASE. This project will determine how an important class of toxic molecules, epipolythiodioxopiperazines (EPTs), are made by fungi. Knowledge of the domains and actions of these genes in the biosynthetic pathway may lead to the ability to engineer secondary metabolites with altered specificity, and drugs that alleviate symptoms of secondary fungal toxicoses associated with leukemia, organ transplants and HIV AIDS. Also this project will a ....BIOSYNTHESIS OF A FUNGAL TOXIN AND ITS ROLE IN PLANT DISEASE. This project will determine how an important class of toxic molecules, epipolythiodioxopiperazines (EPTs), are made by fungi. Knowledge of the domains and actions of these genes in the biosynthetic pathway may lead to the ability to engineer secondary metabolites with altered specificity, and drugs that alleviate symptoms of secondary fungal toxicoses associated with leukemia, organ transplants and HIV AIDS. Also this project will also elucidate the role of an EPT, sirodesmin, in blackleg of canola, a disease that costs the Australian canola industry up to $50 million in losses annually. Outcomes of this project may lead to novel blackleg disease control strategies. Read moreRead less
Blended calcium-magnesium binders for improved and more sustainable building materials. The project will explore the potential of new blended calcium-magnesium cements to significantly improve the sustainability and properties of concrete produced with Portland cement (PC). Concrete based on PC contributes to around 10% of global anthropogenic carbon dioxide. PC Concrete has many weaknesses such as rapid deterioration when exposed to aggressive environments, delayed reactions and early age crack ....Blended calcium-magnesium binders for improved and more sustainable building materials. The project will explore the potential of new blended calcium-magnesium cements to significantly improve the sustainability and properties of concrete produced with Portland cement (PC). Concrete based on PC contributes to around 10% of global anthropogenic carbon dioxide. PC Concrete has many weaknesses such as rapid deterioration when exposed to aggressive environments, delayed reactions and early age cracking caused by shrinkage. The proposed research will investigate ways of using the new binder system to overcome these weaknesses and to reduce carbon dioxide emission. The expected outcome will be a proven technology for manufacturing new building materials that are environmentally more sustainable and with enhanced properties.Read moreRead less